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10MH
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TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND HEMIMETHYLATED DNA CONTAINING 5,6-DIHYDRO-5-AZACYTOSINE AT THE TARGET
Descriptor:DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*5NCP*GP*CP*AP*TP*GP*G)-3'), PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), ...
Authors:Sheikhnejad, G., Brank, A., Christman, J.K., Goddard, A., Alvarez, E., Ford Junior, H., Marquez, V.E., Marasco, C.J., Sufrin, J.R., O'Gara, M., Cheng, X.
Deposit date:1998-08-10
Release date:1999-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine.
J.Mol.Biol., 285, 1999
2OPM
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HUMAN FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH BISPHOSPHONATE BPH-461
Descriptor:Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)], PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Cao, R., Gao, Y.G., Robinson, H., Goddard, A.
Deposit date:2007-01-29
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
J.Am.Chem.Soc., 131, 2009
3DYF
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T. BRUCEI FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH BISPHOSPHONATE BPH-461 AND ISOPENTYL DIPHOSPHATE
Descriptor:FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, ACETATE ION, ...
Authors:Cao, R., Gao, Y., Robinson, H., Goddard, A., Oldfield, E.
Deposit date:2008-07-27
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
J.Am.Chem.Soc., 131, 2009
3DYG
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T. BRUCEI FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH BISPHOSPHONATE BPH-461
Descriptor:FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, ACETATE ION, ...
Authors:Cao, R., Gao, Y., Robinson, H., Goddard, A., Oldfield, E.
Deposit date:2008-07-27
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
J.Am.Chem.Soc., 131, 2009
3DYH
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T. BRUCEI FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH BISPHOSPHONATE BPH-721
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-butoxy-1-(2,2-diphosphonoethyl)pyridinium
Authors:Cao, R., Gao, Y., Robinson, H., Goddard, A., Oldfield, E.
Deposit date:2008-07-27
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
J.Am.Chem.Soc., 131, 2009
2OGD
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T. BRUCEI FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH BISPHOSPHONATE BPH-527
Descriptor:Farnesyl pyrophosphate synthase, ACETATE ION, MAGNESIUM ION, ...
Authors:Cao, R., Gao, Y., Robinson, H., Goddard, A., Oldfield, E.
Deposit date:2007-01-05
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Bisphosphonates: Teaching Old Drugs with New Tricks
TO BE PUBLISHED
2OPN
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HUMAN FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH BISPHOSPHONATE BPH-527
Descriptor:Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)], MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Cao, R., Gao, Y.G., Robinson, H., Goddard, A., Oldfield, E.
Deposit date:2007-01-29
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Bisphosphonates: Teaching Old Drugs with New Tricks
To be Published
2ZEU
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH BPH-715
Descriptor:Geranylgeranyl pyrophosphate synthetase, 3-(DECYLOXY)-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM
Authors:Guo, R.T., Chen, C.K.-M., Cao, R., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-12-17
Release date:2008-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation
J.Am.Chem.Soc., 131, 2009
2ZEV
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM, IPP AND BPH-715
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 3-(DECYLOXY)-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM, ...
Authors:Guo, R.T., Chen, C.K.-M., Cao, R., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-12-17
Release date:2008-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation
J.Am.Chem.Soc., 131, 2009
3EFQ
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T. BRUCEI FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH BISPHOSPHONATE BPH-714
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-(2,2-diphosphonoethyl)-3-(octyloxy)pyridinium
Authors:Cao, R., Gao, Y., Robinson, H., Oldfield, E.
Deposit date:2008-09-09
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
J.Am.Chem.Soc., 131, 2009
3EGT
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T. BRUCEI FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH BISPHOSPHONATE BPH-722
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-(2,2-diphosphonoethyl)-3-(heptyloxy)pyridinium
Authors:Cao, R., Gao, Y., Robinson, H., Oldfield, E.
Deposit date:2008-09-11
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
J.Am.Chem.Soc., 131, 2009
2EWG
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T. BRUCEI FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH MINODRONATE
Descriptor:farnesyl pyrophosphate synthase, MAGNESIUM ION, (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID), ...
Authors:Cao, R., Mao, J., Gao, Y., Robinson, H., Odeh, S., Goddard, A., Oldfield, E.
Deposit date:2005-11-03
Release date:2006-10-31
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes.
J.Am.Chem.Soc., 128, 2006
2I19
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T. BRUCEI FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH BISPHOSPHONATE
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, [2-(PYRIDIN-2-YLAMINO)ETHANE-1,1-DIYL]BIS(PHOSPHONIC ACID)
Authors:Cao, R., Mao, J., Gao, Y., Robinson, H., Odeh, S., Goddard, A., Oldfield, E.
Deposit date:2006-08-13
Release date:2006-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes.
J.Am.Chem.Soc., 128, 2006