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1BQ3
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SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE IN COMPLEX WITH INOSITOL HEXAKISPHOSPHATE
Descriptor:PROTEIN (PHOSPHOGLYCERATE MUTASE 1), INOSITOL HEXAKISPHOSPHATE, SULFATE ION
Authors:Rigden, D.J., Phillips, S.E.V., Fothergill-Gilmore, L.A.
Deposit date:1998-08-20
Release date:1998-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis.
J.Mol.Biol., 289, 1999
1BQ4
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SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE IN COMPLEX WITH BENZENE HEXACARBOXYLATE
Descriptor:PROTEIN (PHOSPHOGLYCERATE MUTASE 1), SULFATE ION, BENZENE HEXACARBOXYLIC ACID
Authors:Rigden, D.J., Phillips, S.E.V., Fothergill-Gilmore, L.A.
Deposit date:1998-08-20
Release date:1998-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis.
J.Mol.Biol., 289, 1999
1FZT
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SOLUTION STRUCTURE AND DYNAMICS OF AN OPEN B-SHEET, GLYCOLYTIC ENZYME-MONOMERIC 23.7 KDA PHOSPHOGLYCERATE MUTASE FROM SCHIZOSACCHAROMYCES POMBE
Descriptor:PHOSPHOGLYCERATE MUTASE
Authors:Uhrinova, S., Uhrin, D., Nairn, J., Price, N.C., Fothergill-Gilmore, L.A.
Deposit date:2000-10-04
Release date:2001-03-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and dynamics of an open beta-sheet, glycolytic enzyme, monomeric 23.7 kDa phosphoglycerate mutase from Schizosaccharomyces pombe.
J.Mol.Biol., 306, 2001
5PGM
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SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE
Descriptor:PHOSPHOGLYCERATE MUTASE 1, SULFATE ION, ALANINE
Authors:Rigden, D.J., Phillips, S.E.V., Fothergill-Gilmore, L.A.
Deposit date:1998-08-19
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Sulphate ions observed in the 2.12 A structure of a new crystal form of S. cerevisiae phosphoglycerate mutase provide insights into understanding the catalytic mechanism.
J.Mol.Biol., 286, 1999
4PGM
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SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE
Descriptor:PHOSPHOGLYCERATE MUTASE 1
Authors:Rigden, D.J., Alexeev, D., Phillips, S.E.V., Fothergill-Gilmore, L.A.
Deposit date:1997-04-25
Release date:1997-10-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The 2.3 A X-ray crystal structure of S. cerevisiae phosphoglycerate mutase.
J.Mol.Biol., 276, 1998
1JI3
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CRYSTAL STRUCTURE OF THE FIRST THERMOSTABLE BACTERIAL LIPASE FROM BACILLUS STEAROTHERMOPHILUS
Descriptor:lipase, CALCIUM ION, ZINC ION
Authors:Tyndall, J.D.A., Sinchaikul, S., Fothergill-Gilmore, L.A., Taylor, P., Walkinshaw, M.D.
Deposit date:2001-06-29
Release date:2002-11-01
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of a Thermostable Lipase from Bacillus stearothermophilus P1
J.Mol.Biol., 323, 2002
1PKL
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THE STRUCTURE OF LEISHMANIA PYRUVATE KINASE
Descriptor:PROTEIN (PYRUVATE KINASE), SULFATE ION
Authors:Rigden, D.J., Phillips, S.E.V., Michels, P.A.M., Fothergill-Gilmore, L.A.
Deposit date:1998-09-15
Release date:1998-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity.
J.Mol.Biol., 291, 1999
2HIG
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CRYSTAL STRUCTURE OF PHOSPHOFRUCTOKINASE APOENZYME FROM TRYPANOSOMA BRUCEI.
Descriptor:6-phospho-1-fructokinase, SODIUM ION
Authors:Martinez-Oyanedel, J., McNae, I.W., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2006-06-29
Release date:2007-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The First Crystal Structure of Phosphofructokinase from a Eukaryote: Trypanosoma brucei.
J.Mol.Biol., 366, 2007
3F5M
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CRYSTAL STRUCTURE OF ATP-BOUND PHOSPHOFRUCTOKINASE FROM TRYPANOSOMA BRUCEI
Descriptor:6-phospho-1-fructokinase (ATP-dependent phosphofructokinase), ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:McNae, I.W., Martinez-Oyanedel, J., Keillor, J.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2008-11-04
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of ATP-bound phosphofructokinase from Trypanosoma brucei reveals conformational transitions different from those of other phosphofructokinases.
J.Mol.Biol., 385, 2009
3IGY
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CRYSTAL STRUCTURES OF LEISHMANIA MEXICANA PHOSPHOGLYCERATE MUTASE AT HIGH COBALT CONCENTRATIONS
Descriptor:Cofactor-independent phosphoglycerate mutase, COBALT (II) ION, SODIUM ION, ...
Authors:Nowicki, M.W., Kuaprasert, B., McNae, I.W., Morgan, H.P., Harding, M.M., Michels, P.A., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2009-07-29
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass
J.Mol.Biol., 394, 2009
3IGZ
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CRYSTAL STRUCTURES OF LEISHMANIA MEXICANA PHOSPHOGLYCERATE MUTASE AT LOW COBALT CONCENTRATION
Descriptor:Cofactor-independent phosphoglycerate mutase, COBALT (II) ION, SODIUM ION, ...
Authors:Nowicki, M.W., Kuaprasert, B., McNae, I.W., Morgan, H.P., Harding, M.M., Michels, P.A., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2009-07-29
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass
J.Mol.Biol., 394, 2009
3PP7
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA PYRUVATE KINASE IN COMPLEX WITH THE DRUG SURAMIN, AN INHIBITOR OF GLYCOLYSIS.
Descriptor:Pyruvate kinase, pyrene-1,3,6,8-tetrasulfonic acid, GLYCEROL, ...
Authors:Morgan, H.P., Auld, D.S., McNae, I.W., Nowicki, M.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2010-11-24
Release date:2010-12-15
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV6
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA PYRUVATE KINASE(LMPYK)IN COMPLEX WITH ACID BLUE 80.
Descriptor:Pyruvate kinase, 3-({4-[(2,4-dimethyl-5-sulfophenyl)amino]-9,10-dioxo-9,10-dihydroanthracen-1-yl}amino)-2,4,6-trimethylbenzenesulfonic acid, POTASSIUM ION, ...
Authors:Morgan, H.P., Auld, D.S., McNae, I.W., Nowicki, M.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-06-29
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV7
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA PYRUVATE KINASE(LMPYK)IN COMPLEX WITH PONCEAU S AND ACID BLUE 25.
Descriptor:Pyruvate kinase, SULFATE ION, POTASSIUM ION, ...
Authors:Morgan, H.P., Auld, D.S., McNae, I.W., Nowicki, M.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-06-29
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV8
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA PYRUVATE KINASE(LMPYK)IN COMPLEX WITH BENZOTHIAZOLE-2,5-DISULFONIC ACID.
Descriptor:Pyruvate kinase, 1,3-benzothiazole-2,5-disulfonic acid, PHOSPHATE ION
Authors:Morgan, H.P., Auld, D.S., McNae, I.W., Nowicki, M.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-06-29
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV9
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CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI PYRUVATE KINASE(TCPYK)IN COMPLEX WITH PONCEAU S.
Descriptor:Pyruvate kinase 2, POTASSIUM ION, PHOSPHATE ION, ...
Authors:Morgan, H.P., Auld, D.S., McNae, I.W., Nowicki, M.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-07-06
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3SRD
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HUMAN M2 PYRUVATE KINASE IN COMPLEX WITH FRUCTOSE 1-6 BISPHOSPHATE AND OXALATE.
Descriptor:Pyruvate kinase isozymes M1/M2, OXALATE ION, BETA-FRUCTOSE-1,6-DIPHOSPHATE, ...
Authors:Morgan, H.P., O'Reilly, F., Palmer, R., McNae, I.W., Nowicki, M.W., Wear, M.A., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-08-08
Method:X-RAY DIFFRACTION (2.902 Å)
Cite:Allosetric regulation of M2 pyruvate kinase.
To be Published
3SRF
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HUMAN M1 PYRUVATE KINASE
Descriptor:Pyruvate kinase isozymes M1/M2, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Morgan, H.P., O'Reilly, F., Palmer, R., McNae, I.W., Nowicki, M.W., Wear, M.A., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-08-08
Method:X-RAY DIFFRACTION (2.845 Å)
Cite:Allosetric regulation of M2 pyruvate kinase.
To be Published
3SRH
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HUMAN M2 PYRUVATE KINASE
Descriptor:Pyruvate kinase isozymes M1/M2, PHOSPHATE ION
Authors:Morgan, H.P., O'Reilly, F., Palmer, R., McNae, I.W., Nowicki, M.W., Wear, M.A., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-08-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosetric regulation of M2 pyruvate kinase.
To be Published
3SRK
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A NEW CLASS OF SUICIDE INHIBITOR BLOCKS NUCLEOTIDE BINDING TO PYRUVATE KINASE
Descriptor:Pyruvate kinase, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, POTASSIUM ION, ...
Authors:Morgan, H.P., Walsh, M., Blackburn, E.A., Wear, M.A., Boxer, M., Shen, M., McNae, I.W., Michels, P.A.M., Auld, D.S., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-07-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
To be Published
4HYV
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PYRUVATE KINASE (PYK) FROM TRYPANOSOMA BRUCEI IN THE PRESENCE OF MAGNESIUM, PEP AND F26BP
Descriptor:Pyruvate kinase 1, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2012-11-14
Release date:2013-09-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase.
Acta Crystallogr.,Sect.D, 69, 2013
4HYW
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PYRUVATE KINASE (PYK) FROM TRYPANOSOMA BRUCEI IN THE PRESENCE OF MAGNESIUM AND F26BP
Descriptor:Pyruvate kinase 1, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2012-11-14
Release date:2013-09-11
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase.
Acta Crystallogr.,Sect.D, 69, 2013
4KCT
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PYRUVATE KINASE (PYK) FROM TRYPANOSOMA BRUCEI SOAKED WITH OXALOACETATE
Descriptor:Pyruvate kinase 1, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2013-04-24
Release date:2014-01-08
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Pyruvate kinases have an intrinsic and conserved decarboxylase activity.
Biochem.J., 458, 2014
4KCU
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PYRUVATE KINASE (PYK) FROM TRYPANOSOMA BRUCEI SOAKED WITH D-MALATE
Descriptor:Pyruvate kinase 1, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2013-04-24
Release date:2014-01-08
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Pyruvate kinases have an intrinsic and conserved decarboxylase activity.
Biochem.J., 458, 2014
4KCV
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PYRUVATE KINASE (PYK) FROM TRYPANOSOMA BRUCEI SOAKED WITH 2-OXOGLUTARIC ACID
Descriptor:Pyruvate kinase 1, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2013-04-24
Release date:2014-01-08
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Pyruvate kinases have an intrinsic and conserved decarboxylase activity.
Biochem.J., 458, 2014
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