Author results

5N2P
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SULFOLOBUS SOLFATARICUS TRYPTOPHAN SYNTHASE A
Descriptor:Tryptophan synthase alpha chain, TETRAETHYLENE GLYCOL, CHLORIDE ION
Authors:Fleming, J., Mayans, O.
Deposit date:2017-02-08
Release date:2018-06-13
Method:X-RAY DIFFRACTION (2.059 Å)
Cite:Evolution of alternative functional interfaces in the metabolic channel Tryptophan Synthase: indels as mechanistic drivers
To Be Published
6EQN
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SULFOLOBUS SOLFATARICUS TRYPTOPHAN SYNTHASE B2O
Descriptor:Tryptophan synthase beta chain 2, PYRIDOXAL-5'-PHOSPHATE
Authors:Fleming, J., Mayans, O., Bucher, R.
Deposit date:2017-10-13
Release date:2017-12-20
Method:X-RAY DIFFRACTION (1.961 Å)
Cite:Evolution of alternative functional interfaces in the metabolic channel Tryptophan Synthase: indels as mechanistic drivers
To Be Published
6HTE
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SULFOLOBUS SOLFATARICUS TRYPTOPHAN SYNTHASE B2A
Descriptor:Tryptophan synthase beta chain 2, DI(HYDROXYETHYL)ETHER, PYRIDOXAL-5'-PHOSPHATE
Authors:Fleming, J., Mayans, O., Bucher, R.
Deposit date:2018-10-04
Release date:2018-11-21
Method:X-RAY DIFFRACTION (1.961 Å)
Cite:Evolution of alternative functional interfaces in the metabolic channel Tryptophan Synthase: indels as mechanistic drivers
To Be Published
4G1T
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CRYSTAL STRUCTURE OF INTERFERON-STIMULATED GENE 54
Descriptor:Interferon-induced protein with tetratricopeptide repeats 2
Authors:Yang, Z., Liang, H., Zhou, Q., Li, Y., Chen, H., Ye, W., Chen, D., Fleming, J., Shu, H., Liu, Y.
Deposit date:2012-07-11
Release date:2012-08-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.
Cell Res., 2012
6FWX
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CHIMERIC TITIN Z1Z2-Z1Z2 TANDEM (Z1212) FUNCTIONALIZED WITH A GRGDS EXOGENOUS PEPTIDE FROM FIBRONECTIN
Descriptor:Titin,Titin,Titin, 1,2-ETHANEDIOL
Authors:Mayans, O., Fleming, J., Hill, C.
Deposit date:2018-03-07
Release date:2019-03-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Chimeric titin Z1Z2-Z1Z2 tandem (Z1212) functionalized with a GRGDS exogenous peptide from fibronectin
To Be Published
5JOE
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CRYSTAL STRUCTURE OF I81 FROM TITIN
Descriptor:Titin, ISOPROPYL ALCOHOL, 1,2-ETHANEDIOL
Authors:Fleming, J., Zhou, T., Bogomolovas, J., Labeit, S., Mayans, O.
Deposit date:2016-05-02
Release date:2016-08-17
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex.
Febs Lett., 590, 2016
4COO
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CRYSTAL STRUCTURE OF HUMAN CYSTATHIONINE BETA-SYNTHASE (DELTA516-525) AT 2.0 ANGSTROM RESOLUTION
Descriptor:CYSTATHIONINE BETA-SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:McCorvie, T.J., Kopec, J., Vollamar, M., Strain-Damerell, C., Bushell, S., Bradley, A., Tallant, C., Kiyani, W., Froese, D.S., Carpenter, E.S., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-01-29
Release date:2014-03-05
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation.
J.Biol.Chem., 289, 2014
4UUU
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1.7 A RESOLUTION STRUCTURE OF HUMAN CYSTATHIONINE BETA-SYNTHASE REGULATORY DOMAIN (DEL 516-525) IN COMPLEX WITH SAM
Descriptor:CYSTATHIONINE BETA-SYNTHASE, S-ADENOSYLMETHIONINE, 1,2-ETHANEDIOL
Authors:Kopec, J., McCorvie, T.J., Fitzpatrick, F., Strain-Damerell, C., Froese, D.S., Tallant, C., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-07-31
Release date:2014-08-13
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation.
J.Biol.Chem., 289, 2014
3WY7
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CRYSTAL STRUCTURE OF MYCOBACTERIUM SMEGMATIS 7-KETO-8-AMINOPELARGONIC ACID (KAPA) SYNTHASE BIOF
Descriptor:8-amino-7-oxononanoate synthase
Authors:Fan, S.H., Li, D.F., Wang, D.C., Chen, G.J., Zhang, X.E., Bi, L.J.
Deposit date:2014-08-20
Release date:2014-12-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and function of Mycobacterium smegmatis 7-keto-8-aminopelargonic acid (KAPA) synthase
Int.J.Biochem.Cell Biol., 58C, 2014
3X3M
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CRYSTAL STRUCTURE OF ECCB1 OF MYCOBACTERIUM TUBERCULOSIS IN SPACEGROUP P212121
Descriptor:ESX-1 secretion system protein EccB1, CALCIUM ION
Authors:Zhang, X.L., Li, D.F., Zhang, X.E., Bi, L.J., Wang, D.C.
Deposit date:2015-01-24
Release date:2015-12-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase.
Faseb J., 2015
3X3N
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CRYSTAL STRUCTURE OF ECCB1 OF MYCOBACTERIUM TUBERCULOSIS IN SPACEGROUP P21
Descriptor:ESX-1 secretion system protein EccB1, CALCIUM ION
Authors:Zhang, X.L., Li, D.F., Zhang, X.E., Bi, L.J., Wang, D.C.
Deposit date:2015-01-24
Release date:2015-12-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase.
Faseb J., 2015
5HSM
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887
Descriptor:Uncharacterized HTH-type transcriptional regulator Rv2887, SULFATE ION
Authors:Gao, Y.R., Li, D.F., Wang, D.C., Bi, L.J.
Deposit date:2016-01-26
Release date:2017-02-01
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis
Sci Rep, 7, 2017
5HSO
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH DNA
Descriptor:Uncharacterized HTH-type transcriptional regulator Rv2887, DNA (30-MER), the upstream sequence of Rv0560c
Authors:Gao, Y.R., Li, D.F., Wang, D.C., Bi, L.J.
Deposit date:2016-01-26
Release date:2017-02-01
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis
Sci Rep, 7, 2017
5X7Z
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH P-AMINOSALICYLIC ACID
Descriptor:Uncharacterized HTH-type transcriptional regulator Rv2887, 2-HYDROXY-4-AMINOBENZOIC ACID
Authors:Gao, Y.R., Li, D.F., Wang, D.C., Bi, L.J.
Deposit date:2017-02-28
Release date:2017-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis
Sci Rep, 7, 2017
5X80
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH SALICYLIC ACID
Descriptor:Uncharacterized HTH-type transcriptional regulator Rv2887, 2-HYDROXYBENZOIC ACID, SULFATE ION
Authors:Gao, Y.R., Li, D.F., Wang, D.C., Bi, L.J.
Deposit date:2017-02-28
Release date:2017-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis
Sci Rep, 7, 2017
5D6J
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CRYSTAL STRUCTURE OF A MYCOBACTERIAL PROTEIN
Descriptor:Acyl-CoA synthase, Ubiquitin-like protein SMT3, MAGNESIUM ION, ...
Authors:Li, W.J., Bi, L.J.
Deposit date:2015-08-12
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of FadD32, an enzyme essential for mycolic acid biosynthesis in mycobacteria.
Sci Rep, 5, 2015
5D6N
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CRYSTAL STRUCTURE OF A MYCOBACTERIAL PROTEIN
Descriptor:Acyl-CoA synthase
Authors:Li, W.J., Bi, L.J.
Deposit date:2015-08-12
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Crystal structure of FadD32, an enzyme essential for mycolic acid biosynthesis in mycobacteria.
Sci Rep, 5, 2015
5EBC
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CRYSTAL STRUCTURE OF ECCB1 OF MYCOBACTERIUM TUBERCULOSIS IN SPACEGROUP P21 (STATE III)
Descriptor:ESX-1 secretion system protein eccB1, CALCIUM ION
Authors:Zhang, X.L., Qi, C., Xie, X.Q., Li, D.F., Bi, L.J.
Deposit date:2015-10-19
Release date:2016-02-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystallographic observation of the movement of the membrane-distal domain of the T7SS core component EccB1 from Mycobacterium tuberculosis.
Acta Crystallogr.,Sect.F, 72, 2016
5EBD
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CRYSTAL STRUCTURE OF ECCB1 OF MYCOBACTERIUM TUBERCULOSIS IN SPACEGROUP P21 (STATE IV)
Descriptor:ESX-1 secretion system protein eccB1, CALCIUM ION, CHLORIDE ION
Authors:Zhang, X.L., Qi, C., Xie, X.Q., Li, D.F., Bi, L.J.
Deposit date:2015-10-19
Release date:2016-02-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystallographic observation of the movement of the membrane-distal domain of the T7SS core component EccB1 from Mycobacterium tuberculosis.
Acta Crystallogr.,Sect.F, 72, 2016
5IMU
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A FRAGMENT OF CONSERVED HYPOTHETICAL PROTEIN RV3899C (RESIDUES 184-410) FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Tat (Twin-arginine translocation) pathway signal sequence containing protein, POTASSIUM ION
Authors:Li, D.F., Gao, Y.R., Liu, Y.Y., Bi, L.J.
Deposit date:2016-03-07
Release date:2017-03-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of Rv3899c(184-410), a hypothetical protein from Mycobacterium tuberculosis
Acta Crystallogr F Struct Biol Commun, 72, 2016
5YPI
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CRYSTAL STRUCTURE OF NDM-1 BOUND TO HYDROLYZED IMIPENEM REPRESENTING AN EI1 COMPLEX
Descriptor:Metallo-beta-lactamase NDM-1, ZINC ION, (2R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-(2-methanimidamidoethylsulfanyl)-2,3-dihydro-1H-pyrrole-5-carboxylic acid, ...
Authors:Feng, H., Wang, D., Liu, W.
Deposit date:2017-11-01
Release date:2018-02-21
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis.
Nat Commun, 8, 2017
5YPK
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CRYSTAL STRUCTURE OF NDM-1 BOUND TO HYDROLYZED IMIPENEM REPRESENTING AN EI2 COMPLEX
Descriptor:Metallo-beta-lactamase NDM-1, ZINC ION, (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-carboxylic acid, ...
Authors:Feng, H., Wang, D., Liu, W.
Deposit date:2017-11-02
Release date:2018-02-21
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis.
Nat Commun, 8, 2017
5YPL
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CRYSTAL STRUCTURE OF NDM-1 BOUND TO HYDROLYZED IMIPENEM REPRESENTING AN EP COMPLEX
Descriptor:Metallo-beta-lactamase NDM-1, ZINC ION, (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-carboxylic acid, ...
Authors:Feng, H., Wang, D., Liu, W.
Deposit date:2017-11-02
Release date:2018-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis.
Nat Commun, 8, 2017
5YPM
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CRYSTAL STRUCTURE OF NDM-1 BOUND TO HYDROLYZED MEROPENEM REPRESENTING AN EI1 COMPLEX
Descriptor:Metallo-beta-lactamase NDM-1, ZINC ION, (2S,3R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-3-methyl-2,3-dihydro-1H-pyrrole-5-carboxylic acid, ...
Authors:Feng, H., Wang, D., Liu, W.
Deposit date:2017-11-02
Release date:2018-02-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis.
Nat Commun, 8, 2017
5YPN
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CRYSTAL STRUCTURE OF NDM-1 BOUND TO HYDROLYZED MEROPENEM REPRESENTING AN EI2 COMPLEX
Descriptor:Metallo-beta-lactamase NDM-1, ZINC ION, (2~{S},3~{R},4~{S})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-3-methyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, ...
Authors:Feng, H., Liu, W., Wang, D.
Deposit date:2017-11-02
Release date:2018-02-21
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis.
Nat Commun, 8, 2017
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