Author results

3GUR
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CRYSTAL STRUCTURE OF MU CLASS GLUTATHIONE S-TRANSFERASE (GSTM2-2) IN COMPLEX WITH GLUTATHIONE AND 6-(7-NITRO-2,1,3-BENZOXADIAZOL-4-YLTHIO)HEXANOL (NBDHEX)
Descriptor:Glutathione S-transferase Mu 2, L-gamma-glutamyl-S-{(4R)-4-[(6-hydroxyhexyl)sulfanyl]-7-nitro-4,5-dihydro-2,1,3-benzoxadiazol-4-yl}-L-cysteinylglycine, GLUTATHIONE, ...
Authors:Federici, L., Lo Sterzo, C., Di Matteo, A., Scaloni, F., Federici, G., Caccuri, A.M.
Deposit date:2009-03-30
Release date:2009-10-27
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases
Cancer Res., 69, 2009
3GUS
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CRYSTAL STRCTURE OF HUMAN PI CLASS GLUTATHIONE S-TRANSFERASE GSTP1-1 IN COMPLEX WITH 6-(7-NITRO-2,1,3-BENZOXADIAZOL-4-YLTHIO)HEXANOL (NBDHEX)
Descriptor:Glutathione S-transferase P, GLUTATHIONE, 6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]hexan-1-ol, ...
Authors:Federici, L., Lo Sterzo, C., Di Matteo, A., Scaloni, F., Federici, G., Caccuri, A.M.
Deposit date:2009-03-30
Release date:2009-10-27
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases
Cancer Res., 69, 2009
3IE3
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STRUCTURAL BASIS FOR THE BINDING OF THE ANTI-CANCER COMPOUND 6-(7-NITRO-2,1,3-BENZOXADIAZOL-4-YLTHIO)HEXANOL (NBDHEX) TO HUMAN GLUTATHIONE S-TRANSFERASES
Descriptor:Glutathione S-transferase P, GLUTATHIONE, 6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]hexan-1-ol, ...
Authors:Federici, L., Lo Sterzo, C., Di Matteo, A., Scaloni, F., Federici, G., Caccuri, A.M.
Deposit date:2009-07-22
Release date:2009-10-27
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases
Cancer Res., 69, 2009
1LBK
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CRYSTAL STRUCTURE OF A RECOMBINANT GLUTATHIONE TRANSFERASE, CREATED BY REPLACING THE LAST SEVEN RESIDUES OF EACH SUBUNIT OF THE HUMAN CLASS PI ISOENZYME WITH THE ADDITIONAL C-TERMINAL HELIX OF HUMAN CLASS ALPHA ISOENZYME
Descriptor:Glutathione S-transferase class pi chimaera (CODA), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, ...
Authors:Kong, G.K.W., Micaloni, C., Mazzetti, A.P., Nuccetelli, M., Antonini, G., Stella, L., McKinstry, W.J., Polekhina, G., Rossjohn, J., Federici, G., Ricci, G., Parker, M.W., Lo Bello, M.
Deposit date:2002-04-04
Release date:2002-04-17
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences.
J.Mol.Biol., 325, 2003
14GS
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GLUTATHIONE S-TRANSFERASE P1-1 APO FORM 1
Descriptor:GLUTATHIONE S-TRANSFERASE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A.J., Lo Bello, M., Ricci, G., Federici, G., Parker, M.W.
Deposit date:1997-11-29
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Evidence for an induced-fit mechanism operating in pi class glutathione transferases.
Biochemistry, 37, 1998
16GS
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GLUTATHIONE S-TRANSFERASE P1-1 APO FORM 3
Descriptor:GLUTATHIONE S-TRANSFERASE, SULFATE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A.J., Lo Bello, M., Ricci, G., Federici, G., Parker, M.W.
Deposit date:1997-11-30
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Evidence for an induced-fit mechanism operating in pi class glutathione transferases.
Biochemistry, 37, 1998
11GS
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GLUTATHIONE S-TRANSFERASE COMPLEXED WITH ETHACRYNIC ACID-GLUTATHIONE CONJUGATE (FORM II)
Descriptor:GLUTATHIONE S-TRANSFERASE, GLUTATHIONE, ETHACRYNIC ACID, ...
Authors:Oakley, A.J., Lo Bello, M., Mazzetti, A.P., Federici, G., Parker, M.W.
Deposit date:1997-11-03
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes.
FEBS Lett., 419, 1997
1GSS
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THREE-DIMENSIONAL STRUCTURE OF CLASS PI GLUTATHIONE S-TRANSFERASE FROM HUMAN PLACENTA IN COMPLEX WITH S-HEXYLGLUTATHIONE AT 2.8 ANGSTROMS RESOLUTION
Descriptor:GLUTATHIONE S-TRANSFERASE, L-gamma-glutamyl-S-hexyl-L-cysteinylglycine
Authors:Reinemer, P., Dirr, H.W., Ladenstein, R., Lobello, M., Federici, G., Huber, R., Parker, M.W.
Deposit date:1992-05-28
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 A resolution.
J.Mol.Biol., 227, 1992
2GSS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1 IN COMPLEX WITH ETHACRYNIC ACID
Descriptor:GLUTATHIONE S-TRANSFERASE P1-1, SULFATE ION, ETHACRYNIC ACID, ...
Authors:Oakley, A.J., Rossjohn, J., Parker, M.W.
Deposit date:1996-10-29
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate.
Biochemistry, 36, 1997
3GSS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1 IN COMPLEX WITH ETHACRYNIC ACID-GLUTATHIONE CONJUGATE
Descriptor:GLUTATHIONE S-TRANSFERASE P1-1, SULFATE ION, GLUTATHIONE, ...
Authors:Oakley, A.J., Rossjohn, J., Parker, M.W.
Deposit date:1996-10-29
Release date:1997-11-12
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate.
Biochemistry, 36, 1997
18GS
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GLUTATHIONE S-TRANSFERASE P1-1 COMPLEXED WITH 1-(S-GLUTATHIONYL)-2,4-DINITROBENZENE
Descriptor:GLUTATHIONE S-TRANSFERASE, GLUTATHIONE S-(2,4 DINITROBENZENE), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A.J., Lo Bello, M., Ricci, G., Federici, G., Parker, M.W.
Deposit date:1997-12-07
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).
J.Mol.Biol., 291, 1999
1ZGN
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CRYSTAL STRUCTURE OF THE GLUTATHIONE TRANSFERASE PI IN COMPLEX WITH DINITROSYL-DIGLUTATHIONYL IRON COMPLEX
Descriptor:Glutathione S-transferase P, FE (III) ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Parker, L.J., Adams, J.J., Parker, M.W.
Deposit date:2005-04-21
Release date:2005-11-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo
J.Biol.Chem., 280, 2005
4GSS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1 Y108F MUTANT
Descriptor:GLUTATHIONE S-TRANSFERASE, S-HEXYLGLUTATHIONE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A., Rossjohn, J., Parker, M.
Deposit date:1997-01-20
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme.
Biochemistry, 36, 1997
10GS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH TER117
Descriptor:GLUTATHIONE S-TRANSFERASE P1-1, L-gamma-glutamyl-S-benzyl-N-[(S)-carboxy(phenyl)methyl]-L-cysteinamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A., Parker, M.
Deposit date:1997-08-14
Release date:1998-09-16
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
5GSS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH GLUTATHIONE
Descriptor:GLUTATHIONE S-TRANSFERASE P1-1, GLUTATHIONE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A., Parker, M.
Deposit date:1997-08-11
Release date:1998-09-16
Last modified:2011-12-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
6GSS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH GLUTATHIONE
Descriptor:GLUTATHIONE S-TRANSFERASE P1-1, GLUTATHIONE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A., Parker, M.
Deposit date:1997-08-13
Release date:1998-09-16
Last modified:2011-12-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
7GSS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH GLUTATHIONE
Descriptor:GLUTATHIONE S-TRANSFERASE P1-1, GLUTATHIONE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A., Parker, M.
Deposit date:1997-08-13
Release date:1998-09-16
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
8GSS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH GLUTATHIONE
Descriptor:GLUTATHIONE S-TRANSFERASE P1-1, SULFATE ION, GLUTATHIONE, ...
Authors:Oakley, A., Parker, M.
Deposit date:1997-08-14
Release date:1998-09-16
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
9GSS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH S-HEXYL GLUTATHIONE
Descriptor:GLUTATHIONE S-TRANSFERASE P1-1, SULFATE ION, S-HEXYLGLUTATHIONE, ...
Authors:Oakley, A., Parker, M.
Deposit date:1997-08-14
Release date:1998-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
1GNE
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THE THREE-DIMENSIONAL STRUCTURE OF GLUTATHIONE S-TRANSFERASE OF SCHISTOSOMA JAPONICUM FUSED WITH A CONSERVED NEUTRALIZING EPITOPE ON GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
Descriptor:GLUTATHIONE S-TRANSFERASE, GLUTATHIONE
Authors:Lim, K., Ho, J.X., Keeling, K., Gilliland, G.L., Ji, X., Ruker, F., Carter, D.C.
Deposit date:1994-06-16
Release date:1994-11-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Three-dimensional structure of Schistosoma japonicum glutathione S-transferase fused with a six-amino acid conserved neutralizing epitope of gp41 from HIV.
Protein Sci., 3, 1994
1AQW
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GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE
Descriptor:GLUTATHIONE S-TRANSFERASE, GLUTATHIONE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Prade, L., Huber, R., Manoharan, T.H., Fahl, W.E., Reuter, W.
Deposit date:1997-08-03
Release date:1998-03-18
Last modified:2011-12-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor.
Structure, 5, 1997
1AQX
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GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH MEISENHEIMER COMPLEX
Descriptor:GLUTATHIONE S-TRANSFERASE, 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Prade, L., Huber, R., Manoharan, T.H., Fahl, W.E., Reuter, W.
Deposit date:1997-08-03
Release date:1998-03-18
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor.
Structure, 5, 1997
1PGT
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE S-TRANSFERASE P1-1[V104] COMPLEXED WITH S-HEXYLGLUTATHIONE
Descriptor:GLUTATHIONE S-TRANSFERASE, S-HEXYLGLUTATHIONE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Ji, X.
Deposit date:1997-02-17
Release date:1997-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and function of the xenobiotic substrate-binding site and location of a potential non-substrate-binding site in a class pi glutathione S-transferase.
Biochemistry, 36, 1997
2PGT
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE S-TRANSFERASE P1-1[V104] COMPLEXED WITH (9R,10R)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE
Descriptor:GLUTATHIONE S-TRANSFERASE, SULFATE ION, (9R,10R)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE, ...
Authors:Ji, X.
Deposit date:1997-02-17
Release date:1997-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and function of the xenobiotic substrate-binding site and location of a potential non-substrate-binding site in a class pi glutathione S-transferase.
Biochemistry, 36, 1997
3PGT
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CRYSTAL STRUCTURE OF HGSTP1-1[I104] COMPLEXED WITH THE GSH CONJUGATE OF (+)-ANTI-BPDE
Descriptor:PROTEIN (GLUTATHIONE S-TRANSFERASE), SULFATE ION, 2-AMINO-4-[1-(CARBOXYMETHYL-CARBAMOYL)-2-(9-HYDROXY-7,8-DIOXO-7,8,9,10-TETRAHYDRO-BENZO[DEF]CHRYSEN-10-YLSULFANYL)-ETHYLCARBAMOYL]-BUTYRIC ACID, ...
Authors:Ji, X., Xiao, B.
Deposit date:1999-03-22
Release date:1999-09-01
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1.
Biochemistry, 38, 1999
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