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4C3Z
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NUCLEOTIDE-FREE CRYSTAL STRUCTURE OF NUCLEOTIDE-BINDING DOMAIN 1 FROM HUMAN MRP1 SUPPORTS A GENERAL-BASE CATALYSIS MECHANISM FOR ATP HYDROLYSIS.
Descriptor:MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1, SULFATE ION
Authors:Chaptal, V., Gueguen-Chaignon, V., Magnard, S., Falson, P., Di Pietro, A., Baubichon-Cortay, H.
Deposit date:2013-08-28
Release date:2014-09-10
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Nucleotide-Free Crystal Structure of Nucleotide-Binding Domain 1 from Human Abcc1 Supports a 'General-Base Catalysis' Mechanism for ATP Hydrolysis.
Biochem.Pharm., 3, 2014
4D5U
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STRUCTURE OF OMPF IN I2
Descriptor:OUTER MEMBRANE PROTEIN F
Authors:Chaptal, V., Kilburg, A., Flot, D., Wiseman, B., Aghajari, N., Jault, J.M., Falson, P.
Deposit date:2014-11-07
Release date:2015-12-16
Last modified:2016-01-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Two Different Centered Monoclinic Crystals of the E. Coli Outer-Membrane Protein Ompf Originate from the Same Building Block.
Biochim.Biophys.Acta, 1858, 2016
4JFB
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CRYSTAL STRUCTURE OF OMPF IN C2 WITH TNCS
Descriptor:Outer membrane protein F
Authors:Wiseman, B., Kilburg, A., Chaptal, V., Reyes-Meija, G.C., Sarwan, J., Falson, P., Jault, J.M.
Deposit date:2013-02-28
Release date:2014-03-05
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.801 Å)
Cite:Stubborn contaminants: influence of detergents on the purity of the multidrug ABC transporter BmrA
PLoS ONE, 9, 2014
4KSB
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (3.8001 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KSC
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KSD
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A, R2 protein
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (4.1001 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
5O42
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17BETA-HYDROXYSTEROID DEHYDROGENASE 14 VARIANT T205 IN COMPLEX WITH A NON-STEROIDAL 2,6-PYRIDINKETONE INHIBITOR.
Descriptor:17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ...
Authors:Bertoletti, N., Heine, A., Braun, F., Klebe, G., Marchais-Oberwinkler, S.
Deposit date:2017-05-25
Release date:2018-06-06
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.
Eur J Med Chem, 155, 2018
5O43
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17BETA-HYDROXYSTEROID DEHYDROGENASE 14 VARIANT T205 IN COMPLEX WITH A NON-STEROIDAL 2,6-PYRIDINKETONE INHIBITOR.
Descriptor:17-beta-hydroxysteroid dehydrogenase 14, SODIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Bertoletti, N., Heine, A., Braun, F., Klebe, G., Marchais-Oberwinkler, S.
Deposit date:2017-05-25
Release date:2018-06-06
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.
Eur J Med Chem, 155, 2018
5O6O
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17BETA-HYDROXYSTEROID DEHYDROGENASE 14 VARIANT T205 IN COMPLEX WITH A NON-STEROIDAL 2,6-PYRIDINKETONE INHIBITOR
Descriptor:17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ...
Authors:Bertoletti, N., Heine, A., Braun, F., Klebe, G., Marchais-Oberwinkler, S.
Deposit date:2017-06-07
Release date:2018-06-06
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.
Eur J Med Chem, 155, 2018
5O6X
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17BETA-HYDROXYSTEROID DEHYDROGENASE 14 VARIANT T205 IN COMPLEX WITH A NON-STEROIDAL QUINOLINE BASED INHIBITOR
Descriptor:17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ...
Authors:Bertoletti, N., Braun, F., Heine, A., Klebe, G., Marchais-Oberwinkler, S.
Deposit date:2017-06-07
Release date:2018-06-06
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.
Eur J Med Chem, 155, 2018
5O6Z
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17BETA-HYDROXYSTEROID DEHYDROGENASE 14 VARIANT T205 IN COMPLEX WITH A NON-STEROIDAL QUINOLINE BASED INHIBITOR
Descriptor:17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ...
Authors:Bertoletti, N., Braun, F., Heine, A., Klebe, G., Marchais-Oberwinkler, S.
Deposit date:2017-06-07
Release date:2018-06-06
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.
Eur J Med Chem, 155, 2018
5O72
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17BETA-HYDROXYSTEROID DEHYDROGENASE 14 VARIANT T205 IN COMPLEX WITH A NON-STEROIDAL QUINOLINE BASED INHIBITOR
Descriptor:17-beta-hydroxysteroid dehydrogenase 14, SODIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Bertoletti, N., Braun, F., Heine, A., Klebe, G., Marchais-Oberwinkler, S.
Deposit date:2017-06-07
Release date:2018-06-06
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.
Eur J Med Chem, 155, 2018
5O7C
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17BETA-HYDROXYSTEROID DEHYDROGENASE 14 VARIANT T205 IN COMPLEX WITH A NON-STEROIDAL QUINOLINE BASED INHIBITOR
Descriptor:17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ...
Authors:Bertoletti, N., Braun, F., Heine, A., Klebe, G., Marchais-Oberwinkler, S.
Deposit date:2017-06-08
Release date:2018-06-06
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.
Eur J Med Chem, 155, 2018