5O6X

17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal quinoline based inhibitor

Summary for 5O6X

Entry DOI	10.2210/pdb5o6x/pdb
Descriptor	17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... (6 entities in total)
Functional Keywords	non-steroidal inhibitor, 17beta-hsd14, 2, 6-pyridinketone inhibitors, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29830.59
Authors	Bertoletti, N.,Braun, F.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S. (deposition date: 2017-06-07, release date: 2018-06-06, Last modification date: 2024-01-17)
Primary citation	Braun, F.,Bertoletti, N.,Moller, G.,Adamski, J.,Frotscher, M.,Guragossian, N.,Madeira Girio, P.A.,Le Borgne, M.,Ettouati, L.,Falson, P.,Muller, S.,Vollmer, G.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S. Structure-based design and profiling of novel 17 beta-HSD14 inhibitors. Eur J Med Chem, 155:61-76, 2018 Cited by PubMed: 29859505 DOI: 10.1016/j.ejmech.2018.05.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation