Author results

1OH1
  • Download 1oh1
  • View 1oh1
Molmil generated image of 1oh1
SOLUTION STRUCTURE OF STAPHOSTATIN A FORM STAPHYLOCOCCUS AUREUS CONFIRMS THE DISCOVERY OF A NOVEL CLASS OF CYSTEINE PROTEINASE INHIBITORS.
Descriptor:STAPHOSTATIN A
Authors:Dubin, G., Popowicz, G., Krajewski, M., Stec, J., Bochtler, M., Potempa, J., Dubin, A., Holak, T.A.
Deposit date:2003-05-21
Release date:2003-11-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Novel Class of Cysteine Protease Inhibitors: Solution Structure of Staphostatin a from Staphylococcus Aureus
Biochemistry, 42, 2003
2VID
  • Download 2vid
  • View 2vid
Molmil generated image of 2vid
SERINE PROTEASE SPLB FROM STAPHYLOCOCCUS AUREUS AT 1.8A RESOLUTION
Descriptor:SERINE PROTEASE SPLB
Authors:Dubin, G., Stec-Niemczyk, J., Kisielewska, M., Pustelny, K., Popowicz, G.M., Bista, M., Kantyka, T., Boulware, K.T., Stennicke, H.R., Czarna, A., Phopaisarn, M., Daugherty, P.S., Thogersen, I.B., Enghild, J.J., Thornberry, N., Dubin, A., Potempa, J.
Deposit date:2007-11-30
Release date:2008-05-13
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enzymatic Activity of the Staphylococcus Aureus Splb Serine Protease is Induced by Substrates Containing the Sequence Trp-Glu-Leu-Gln.
J.Mol.Biol., 379, 2008
5O12
  • Download 5o12
  • View 5o12
Molmil generated image of 5o12
CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH SMALL-MOLECULE INHIBITOR
Descriptor:Serine/threonine-protein kinase pim-1, (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, IMIDAZOLE
Authors:Dubin, G., Bogusz, J.
Deposit date:2017-05-17
Release date:2017-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors.
Sci Rep, 7, 2017
5O13
  • Download 5o13
  • View 5o13
Molmil generated image of 5o13
CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH SMALL-MOLECULE INHIBITOR
Descriptor:Serine/threonine-protein kinase pim-1, (3~{E})-5-chloranyl-3-[[5-[3-[(4-methyl-1,4-diazepan-1-yl)carbonyl]phenyl]furan-2-yl]methylidene]-1~{H}-indol-2-one, IMIDAZOLE, ...
Authors:Dubin, G., Bogusz, J.
Deposit date:2017-05-17
Release date:2017-11-01
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors.
Sci Rep, 7, 2017
2W7S
  • Download 2w7s
  • View 2w7s
Molmil generated image of 2w7s
SPLA SERINE PROTEASE OF STAPHYLOCOCCUS AUREUS (1.8A)
Descriptor:SERINE PROTEASE SPLA
Authors:Stec-Niemczyka, J., Pustelny, K., Kisielewska, M., Bista, M., Boulware, K.T., Stennicke, H.R., Thogersen, I.B., Daugherty, P.S., Enghild, J.J., Popowicz, G.M., Dubin, A., Potempa, J., Dubin, G.
Deposit date:2008-12-30
Release date:2010-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Functional Characterization of Spla, an Exclusively Specific Protease of Staphylococcus Aureus
Biochem.J., 419, 2009
2W7U
  • Download 2w7u
  • View 2w7u
Molmil generated image of 2w7u
SPLA SERINE PROTEASE OF STAPHYLOCOCCUS AUREUS (2.4A)
Descriptor:SERINE PROTEASE SPLA
Authors:Stec-Niemczyka, J., Pustelny, K., Kisielewska, M., Bista, M., Boulware, K.T., Stennicke, H.R., Thogersen, I.B., Daugherty, P.S., Enghild, J.J., Popowicz, G.M., Dubin, A., Potempa, J., Dubin, G.
Deposit date:2008-12-30
Release date:2010-03-31
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural and Functional Characterization of Spla, an Exclusively Specific Protease of Staphylococcus Aureus.
Biochem.J., 419, 2009
4K1S
  • Download 4k1s
  • View 4k1s
Molmil generated image of 4k1s
GLY-SER-SPLB PROTEASE FROM STAPHYLOCOCCUS AUREUS AT 1.96 A RESOLUTION
Descriptor:Serine protease SplB
Authors:Zdzalik, M., Pustelny, K., Stec-Niemczyk, J., Cichon, P., Czarna, A., Popowicz, G., Drag, M., Wladyka, B., Potempa, J., Dubin, A., Dubin, G.
Deposit date:2013-04-05
Release date:2014-04-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Staphylococcal SplB Serine Protease Utilizes a Novel Molecular Mechanism of Activation.
J.Biol.Chem., 289, 2014
4K1T
  • Download 4k1t
  • View 4k1t
Molmil generated image of 4k1t
GLY-SER-SPLB PROTEASE FROM STAPHYLOCOCCUS AUREUS AT 1.60 A RESOLUTION
Descriptor:Serine protease SplB, ZINC ION, SULFATE ION, ...
Authors:Zdzalik, M., Pustelny, K., Stec-Niemczyk, J., Cichon, P., Czarna, A., Popowicz, G., Drag, M., Wladyka, B., Potempa, J., Dubin, A., Dubin, G.
Deposit date:2013-04-05
Release date:2014-04-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Staphylococcal SplB Serine Protease Utilizes a Novel Molecular Mechanism of Activation.
J.Biol.Chem., 289, 2014
4MVN
  • Download 4mvn
  • View 4mvn
Molmil generated image of 4mvn
CRYSTAL STRUCTURE OF THE STAPHYLOCOCCAL SERINE PROTEASE SPLA IN COMPLEX WITH A SPECIFIC PHOSPHONATE INHIBITOR
Descriptor:Serine protease splA, [(1S)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl]phosphonic acid
Authors:Zdzalik, M., Burchacka, E., Niemczyk, J.S., Pustelny, K., Popowicz, G.M., Wladyka, B., Dubin, A., Potempa, J., Sienczyk, M., Dubin, G., Oleksyszyn, J.
Deposit date:2013-09-24
Release date:2014-01-22
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus.
Protein Sci., 23, 2014
2AS9
  • Download 2as9
  • View 2as9
Molmil generated image of 2as9
FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF SPL PROTEASES FROM STAPHYLOCOCCUS AUREUS
Descriptor:serine protease, ZINC ION
Authors:Popowicz, G.M., Dubin, G., Stec-Niemczyk, J., Czarny, A., Dubin, A., Potempa, J., Holak, T.A.
Deposit date:2005-08-23
Release date:2005-09-06
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Functional and Structural Characterization of Spl Proteases from Staphylococcus aureus
J.Mol.Biol., 358, 2006
4INK
  • Download 4ink
  • View 4ink
Molmil generated image of 4ink
CRYSTAL STRUCTURE OF SPLD PROTEASE FROM STAPHYLOCOCCUS AUREUS AT 1.56 A RESOLUTION
Descriptor:Serine protease SplD
Authors:Zdzalik, M., Kalinska, M., Cichon, P., Wysocka, M., Stec-Niemczyk, J., Stennicke, H.R., Jabaiah, A., Markiewicz, M., Wladyka, B., Daugherty, P.S., Lesner, A., Rolka, K., Dubin, A., Potempa, J., Dubin, G.
Deposit date:2013-01-04
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Biochemical and Structural Characterization of SplD Protease from Staphylococcus aureus.
Plos One, 8, 2013
4INL
  • Download 4inl
  • View 4inl
Molmil generated image of 4inl
CRYSTAL STRUCTURE OF SPLD PROTEASE FROM STAPHYLOCOCCUS AUREUS AT 2.1 A RESOLUTION
Descriptor:Serine protease SplD
Authors:Cichon, P., Zdzalik, M., Kalinska, M., Wysocka, M., Stec-Niemczyk, J., Stennicke, H.R., Jabaiah, A., Markiewicz, M., Wladyka, B., Daugherty, P.S., Lesner, A., Rolka, K., Dubin, A., Potempa, J., Dubin, G.
Deposit date:2013-01-04
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biochemical and Structural Characterization of SplD Protease from Staphylococcus aureus.
Plos One, 8, 2013
3UFA
  • Download 3ufa
  • View 3ufa
Molmil generated image of 3ufa
CRYSTAL STRUCTURE OF THE STAPHYLOCOCCAL SERINE PROTEASE SPLA IN COMPLEX WITH A SPECIFIC PHOSPHONATE INHIBITOR
Descriptor:Serine protease splA, N-(3-carboxypropanoyl)-L-valyl-N-[(1S)-2-phenyl-1-phosphonoethyl]-L-prolinamide, CHLORIDE ION
Authors:Zdzalik, M., Pietrusewicz, E., Pustelny, K., Stec-Niemczyk, J., Popowicz, G.M., Potempa, J., Oleksyszyn, J., Dubin, G.
Deposit date:2011-10-31
Release date:2013-01-23
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus.
Protein Sci., 23, 2014
5OML
  • Download 5oml
  • View 5oml
Molmil generated image of 5oml
CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI PEX14 N-TERMINAL DOMAIN IN COMPLEX WITH SMALL MOLECULES TO INVESTIGATE THE WATER ENVELOPE
Descriptor:Peroxin 14, (3~{R})-3-[[1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]carbonylamino]-3-phenyl-propanoic acid, SULFATE ION, ...
Authors:Ratkova, E.L., Dawidowski, M., Napolitano, V., Dubin, G., Fino, R., Popowicz, G., Sattler, M., Tetko, I.V.
Deposit date:2017-08-01
Release date:2019-03-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of Trypanosoma Brucei PEX14 N-terminal domain in complex with small molecules to investigate the water envelope
To Be Published
4GR2
  • Download 4gr2
  • View 4gr2
Molmil generated image of 4gr2
STRUCTURE OF ATRBCX1 FROM ARABIDOPSIS THALIANA.
Descriptor:AtRbcX1
Authors:Golik, P., Grudnik, P., Kolesinski, P., Dubin, G., Szczepaniak, A.
Deposit date:2012-08-24
Release date:2013-01-30
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into eukaryotic Rubisco assembly - Crystal structures of RbcX chaperones from Arabidopsis thaliana.
Biochim.Biophys.Acta, 1830, 2013
4GR6
  • Download 4gr6
  • View 4gr6
Molmil generated image of 4gr6
CRYSTAL STRUCTURE OF ATRBCX2 FROM ARABIDOPSIS THALIANA
Descriptor:AtRbcX2, 1,2-ETHANEDIOL
Authors:Grudnik, P., Golik, P., Kolesinski, P., Dubin, G., Szczepaniak, A.
Deposit date:2012-08-24
Release date:2013-01-30
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into eukaryotic Rubisco assembly - Crystal structures of RbcX chaperones from Arabidopsis thaliana.
Biochim.Biophys.Acta, 1830, 2013
4TRP
  • Download 4trp
  • View 4trp
Molmil generated image of 4trp
CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN.
Descriptor:Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen
Authors:Horwacik, I., Golik, P., Grudnik, P., Zdzalik, M., Rokita, H., Dubin, G.
Deposit date:2014-06-17
Release date:2015-07-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
4TUJ
  • Download 4tuj
  • View 4tuj
Molmil generated image of 4tuj
CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN.
Descriptor:Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen, peptide1
Authors:Grudnik, P., Golik, P., Horwacik, I., Zdzalik, M., Rokita, H., Dubin, G.
Deposit date:2014-06-24
Release date:2015-07-15
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
4TUK
  • Download 4tuk
  • View 4tuk
Molmil generated image of 4tuk
CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN.
Descriptor:Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen, peptide2, ...
Authors:Golik, P., Grudnik, P., Dubin, G., Horwacik, I., Zdzalik, M., Rokita, H.
Deposit date:2014-06-24
Release date:2015-07-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
4TUL
  • Download 4tul
  • View 4tul
Molmil generated image of 4tul
CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN.
Descriptor:Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen, peptide2, ...
Authors:Golik, P., Grudnik, P., Dubin, G., Zdzalik, M., Rokita, H., Horwacik, I.
Deposit date:2014-06-24
Release date:2015-07-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
4TUO
  • Download 4tuo
  • View 4tuo
Molmil generated image of 4tuo
CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN.
Descriptor:Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen, SODIUM ION, ...
Authors:Golik, P., Grudnik, P., Horwacik, I., Zdzalik, M., Rokita, H., Dubin, G.
Deposit date:2014-06-24
Release date:2015-07-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
4U2W
  • Download 4u2w
  • View 4u2w
Molmil generated image of 4u2w
ATOMIC RESOLUTION CRYSTAL STRUCTURE OF HV-BBI PROTEASE INHIBITOR FROM AMPHIBIAN SKIN IN COMPLEX WITH BOVINE TRYPSIN
Descriptor:Bowman-Birk trypsin inhibitor, Cationic trypsin, CALCIUM ION, ...
Authors:Grudnik, P., Golik, P., Malicki, S., Debowski, D., Legowska, A., Rolka, K., Dubin, G.
Deposit date:2014-07-18
Release date:2015-01-14
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1 Å)
Cite:Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin.
Proteins, 83, 2015
4XOJ
  • Download 4xoj
  • View 4xoj
Molmil generated image of 4xoj
STRUCTURE OF BOVINE TRYPSIN IN COMPLEX WITH ANALOGUES OF SUNFLOWER INHIBITOR 1 (SFTI-1)
Descriptor:Cationic trypsin, Trypsin inhibitor 1, SULFATE ION, ...
Authors:Golik, P., Malicki, S., Grudnik, P., Karna, N., Debowski, D., Legowska, A., Wladyka, B., Gitlin, A., Brzozowski, K., Dubin, G., Rolka, K.
Deposit date:2015-01-16
Release date:2015-08-12
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (0.91 Å)
Cite:Investigation of Serine-Proteinase-Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI-1).
Chembiochem, 16, 2015
4ZFI
  • Download 4zfi
  • View 4zfi
Molmil generated image of 4zfi
STRUCTURE OF MDM2 WITH LOW MOLECULAR WEIGHT INHIBITOR
Descriptor:E3 ubiquitin-protein ligase Mdm2, (5S)-3,5-bis(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-hydroxy-1-methyl-1,5-dihydro-2H-pyrrol-2-one
Authors:Zak, K.M., Twarda-Clapa, A., Wrona, E.M., Grudnik, P., Dubin, G., Holak, T.A.
Deposit date:2015-04-21
Release date:2016-10-19
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.
ACS Chem. Biol., 11, 2016
4ZGK
  • Download 4zgk
  • View 4zgk
Molmil generated image of 4zgk
STRUCTURE OF MDM2 WITH LOW MOLECULAR WEIGHT INHIBITOR.
Descriptor:E3 ubiquitin-protein ligase Mdm2, (5R)-3,5-bis(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-hydroxyfuran-2(5H)-one
Authors:Twarda-Clapa, A., Zak, K.M., Wrona, E.M., Grudnik, P., Dubin, G., Holak, T.A.
Deposit date:2015-04-23
Release date:2016-10-19
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.
ACS Chem. Biol., 11, 2016
<123>