5O13

Crystal structure of PIM1 kinase in complex with small-molecule inhibitor

Summary for 5O13

Entry DOI	10.2210/pdb5o13/pdb
Descriptor	Serine/threonine-protein kinase pim-1, (3~{E})-5-chloranyl-3-[[5-[3-[(4-methyl-1,4-diazepan-1-yl)carbonyl]phenyl]furan-2-yl]methylidene]-1~{H}-indol-2-one, IMIDAZOLE, ... (5 entities in total)
Functional Keywords	kinase, pim1, cx-6258, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35040.35
Authors	Dubin, G.,Bogusz, J. (deposition date: 2017-05-17, release date: 2017-11-01, Last modification date: 2024-01-17)
Primary citation	Bogusz, J.,Zrubek, K.,Rembacz, K.P.,Grudnik, P.,Golik, P.,Romanowska, M.,Wladyka, B.,Dubin, G. Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors. Sci Rep, 7:13399-13399, 2017 Cited by PubMed: 29042609 DOI: 10.1038/s41598-017-13557-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.44 Å)

Structure validation