5O13
Crystal structure of PIM1 kinase in complex with small-molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase pim-1 | polymer | 298 | 34473.9 | 1 | UniProt (P11309) Pfam (PF00069) | Homo sapiens (Human) | |
| 2 | B (A) | (3~{E})-5-chloranyl-3-[[5-[3-[(4-methyl-1,4-diazepan-1-yl)carbonyl]phenyl]furan-2-yl]methylidene]-1~{H}-indol-2-one | non-polymer | 461.9 | 1 | Chemie (9G5) | |||
| 3 | C (A) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 4 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E (A) | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence modifications
A: 29 - 313 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| His 16 | - | expression tag |
| His 17 | - | expression tag |
| His 18 | - | expression tag |
| His 19 | - | expression tag |
| His 20 | - | expression tag |
| His 21 | - | expression tag |
| Ser 22 | - | expression tag |
| Gln 23 | - | expression tag |
| Asp 24 | - | expression tag |
| Pro 25 | - | expression tag |
| Asn 26 | - | expression tag |
| Ser 27 | - | expression tag |
| Met 28 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34473.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 566.5 | |
| All* | Total formula weight | 35040.4 |
