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4INR
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YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU102
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F.
Deposit date:2013-01-06
Release date:2013-01-30
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
4INT
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YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU122
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F.
Deposit date:2013-01-06
Release date:2013-01-30
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
4INU
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YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU112
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F.
Deposit date:2013-01-06
Release date:2013-01-30
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
4QLQ
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YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 8
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:De Bruin, G., Huber, E., Xin, B., Van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., Van der Marel, G., Groll, M., Overkleeft, H.
Deposit date:2014-06-13
Release date:2014-07-23
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
4QLS
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YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 11
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:De Bruin, G., Huber, E., Xin, B., Van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., Van der Marel, G., Groll, M., Overkleeft, H.
Deposit date:2014-06-13
Release date:2014-07-23
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
4QLT
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YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 2 (PR924)
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:de Bruin, G., Huber, E., Xin, B., van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., van der Marel, G., Groll, M., Overkleeft, H.
Deposit date:2014-06-13
Release date:2014-07-23
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
4QLU
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YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 9
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:de Bruin, G., Huber, E., Xin, B., van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., van der Marel, G., Groll, M., Overkleeft, H.
Deposit date:2014-06-13
Release date:2014-07-23
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
4QLV
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YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 17
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:de Bruin, G., Huber, E., Xin, B., van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., van der Marel, G., Groll, M., Overkleeft, H.
Deposit date:2014-06-13
Release date:2014-07-23
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
6HTB
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YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G)
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-03
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HTC
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YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH ONX 0914
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-03
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HTD
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YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 4
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-03
Release date:2019-01-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HTP
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YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 7
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-04
Release date:2019-01-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HTR
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YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 13
Descriptor:PROTEASOME SUBUNIT ALPHA TYPE-2, Proteasome subunit alpha type-3, PROTEASOME SUBUNIT ALPHA TYPE-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-04
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HUB
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YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 16
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-05
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HUC
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YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 18
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-05
Release date:2019-01-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HUQ
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YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 20
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-09
Release date:2019-01-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HUU
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YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 29
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-09
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HUV
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YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 39
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-09
Release date:2019-01-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HV3
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YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53)
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-10
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HV4
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YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53) IN COMPLEX WITH ONX 0914
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-10
Release date:2019-01-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HV5
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YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53) IN COMPLEX WITH 4
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-10
Release date:2019-01-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HV7
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YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53) IN COMPLEX WITH 7
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-10
Release date:2019-01-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HVA
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YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53) IN COMPLEX WITH 13
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-10
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HVR
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YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53) IN COMPLEX WITH 16
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-11
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
6HVS
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YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53) IN COMPLEX WITH 18
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2018-10-11
Release date:2019-01-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-based design of inhibitors selective for human proteasome beta 2c or beta 2i subunits.
J. Med. Chem., 2019
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