4INR | | YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU102 | | Descriptor: | Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ... | | Authors: | Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F. | | Deposit date: | 2013-01-06 | | Release date: | 2013-01-30 | | Last modified: | 2013-02-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
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4INT | | YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU122 | | Descriptor: | Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ... | | Authors: | Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F. | | Deposit date: | 2013-01-06 | | Release date: | 2013-01-30 | | Last modified: | 2013-02-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
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4INU | | YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU112 | | Descriptor: | Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ... | | Authors: | Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F. | | Deposit date: | 2013-01-06 | | Release date: | 2013-01-30 | | Last modified: | 2013-02-27 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
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4QLQ | | YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 8 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | De Bruin, G., Huber, E., Xin, B., Van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., Van der Marel, G., Groll, M., Overkleeft, H. | | Deposit date: | 2014-06-13 | | Release date: | 2014-07-23 | | Last modified: | 2014-10-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
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4QLS | | YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 11 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | De Bruin, G., Huber, E., Xin, B., Van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., Van der Marel, G., Groll, M., Overkleeft, H. | | Deposit date: | 2014-06-13 | | Release date: | 2014-07-23 | | Last modified: | 2014-10-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
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4QLT | | YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 2 (PR924) | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | de Bruin, G., Huber, E., Xin, B., van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., van der Marel, G., Groll, M., Overkleeft, H. | | Deposit date: | 2014-06-13 | | Release date: | 2014-07-23 | | Last modified: | 2014-10-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
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4QLU | | YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 9 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | de Bruin, G., Huber, E., Xin, B., van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., van der Marel, G., Groll, M., Overkleeft, H. | | Deposit date: | 2014-06-13 | | Release date: | 2014-07-23 | | Last modified: | 2014-10-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
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4QLV | | YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 17 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | de Bruin, G., Huber, E., Xin, B., van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., van der Marel, G., Groll, M., Overkleeft, H. | | Deposit date: | 2014-06-13 | | Release date: | 2014-07-23 | | Last modified: | 2014-10-01 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
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6HTB | | YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-03 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HTC | |
6HTD | | YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 4 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-03 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HTP | | YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 7 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-04 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HTR | | YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 13 | | Descriptor: | PROTEASOME SUBUNIT ALPHA TYPE-2, Proteasome subunit alpha type-3, PROTEASOME SUBUNIT ALPHA TYPE-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-04 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HUB | | YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 16 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-05 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HUC | | YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 18 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-05 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HUQ | | YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 20 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-09 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HUU | | YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 29 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-09 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HUV | | YEAST 20S PROTEASOME WITH HUMAN BETA2C (S171G) IN COMPLEX WITH 39 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-09 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HV3 | | YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53) | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-10 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HV4 | |
6HV5 | | YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53) IN COMPLEX WITH 4 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-10 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HV7 | | YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53) IN COMPLEX WITH 7 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-10 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HVA | | YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53) IN COMPLEX WITH 13 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-10 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HVR | | YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53) IN COMPLEX WITH 16 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-11 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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6HVS | | YEAST 20S PROTEASOME WITH HUMAN BETA2I (1-53) IN COMPLEX WITH 18 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Huber, E.M., Groll, M. | | Deposit date: | 2018-10-11 | | Release date: | 2019-01-30 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62, 2019
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