6HWE

Yeast 20S proteasome beta2-G45A mutant in complex with carfilzomib

Summary for 6HWE

• Entry DOI: 10.2210/pdb6hwe/pdb
• Related: 5CZ4
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (20 entities in total)
• Functional Keywords: proteasome, mutant, inhibitor, binding analysis, hydrolase
• Biological source: Saccharomyces cerevisiae S288C; More
• Total number of polymer chains: 28
• Total formula weight: 736660.90

Authors

Huber, E.M.,Groll, M. (deposition date: 2018-10-11, release date: 2019-01-30, Last modification date: 2024-01-24)

• Primary citation: Xin, B.T.,Huber, E.M.,de Bruin, G.,Heinemeyer, W.,Maurits, E.,Espinal, C.,Du, Y.,Janssens, M.,Weyburne, E.S.,Kisselev, A.F.,Florea, B.I.,Driessen, C.,van der Marel, G.A.,Groll, M.,Overkleeft, H.S.; Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.; J.Med.Chem., 62:1626-1642, 2019; PubMed: 30657666; DOI: 10.1021/acs.jmedchem.8b01884

Experimental method

X-RAY DIFFRACTION (2.3 Å)