4QLT

yCP in complex with tripeptidic epoxyketone inhibitor 2 (PR924)

Summary for 4QLT

Related1RYP 1G65 4QLQ 4QLS 4QLU 4QLV
DescriptorProteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... (18 entities in total)
Functional Keywordsproteasome, epoxyketone, immunoproteasome inhibitor, binding analysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight732877.16
Authors
de Bruin, G.,Huber, E.,Xin, B.,van Rooden, E.,Al-Ayed, K.,Kim, K.,Kisselev, A.,Driessen, C.,van der Marel, G.,Groll, M.,Overkleeft, H. (deposition date: 2014-06-13, release date: 2014-07-23, Last modification date: 2014-10-01)
Primary citation
De Bruin, G.,Huber, E.M.,Xin, B.T.,Van Rooden, E.J.,Al-Ayed, K.,Kim, K.B.,Kisselev, A.F.,Driessen, C.,Van der Stelt, M.,Van der Marel, G.A.,Groll, M.,Overkleeft, H.S.
Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57:6197-6209, 2014
PubMed: 25006746 (PDB entries with the same primary citation)
DOI: 10.1021/jm500716s
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20320.4%6.4%1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution