5JHR

Yeast 20S proteasome in complex with the peptidic epoxyketone inhibitor 27

Summary for 5JHR

Related5CZ4 1G65
DescriptorProteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... (19 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, proteasome, inhibitor, binding analysis, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight733095.65
Authors
Huber, E.M.,Groll, M. (deposition date: 2016-04-21, release date: 2016-08-03, Last modification date: 2016-08-24)
Primary citation
Xin, B.T.,de Bruin, G.,Huber, E.M.,Besse, A.,Florea, B.I.,Filippov, D.V.,van der Marel, G.A.,Kisselev, A.F.,van der Stelt, M.,Driessen, C.,Groll, M.,Overkleeft, H.S.
Structure-Based Design of beta 5c Selective Inhibitors of Human Constitutive Proteasomes.
J.Med.Chem., 59:7177-7187, 2016
PubMed: 27438186 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.6b00705
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20920.2%3.9%2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution