5JHS

Yeast 20S proteasome in complex with the peptidic epoxyketone inhibitor 15

Summary for 5JHS

Entry DOI	10.2210/pdb5jhs/pdb
Related	1G65 5CZ4
Descriptor	Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (19 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, proteasome, inhibitor, binding analysis, hydrolase/hydrolase inhibitor
Biological source	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) More
Cellular location	Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains	28
Total formula weight	734061.35
Authors	Huber, E.M.,Groll, M. (deposition date: 2016-04-21, release date: 2016-08-03, Last modification date: 2024-01-10)
Primary citation	Xin, B.T.,de Bruin, G.,Huber, E.M.,Besse, A.,Florea, B.I.,Filippov, D.V.,van der Marel, G.A.,Kisselev, A.F.,van der Stelt, M.,Driessen, C.,Groll, M.,Overkleeft, H.S. Structure-Based Design of beta 5c Selective Inhibitors of Human Constitutive Proteasomes. J.Med.Chem., 59:7177-7187, 2016 Cited by PubMed: 27438186 DOI: 10.1021/acs.jmedchem.6b00705 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation