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1YSZ
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CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH NECA
Descriptor:Endoplasmin, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, TETRAETHYLENE GLYCOL
Authors:Dollins, D.E., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1YT0
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CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH ADP
Descriptor:Endoplasmin, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Dollins, D.E., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1YT1
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CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N(DELTA)41 APO CRYSTAL
Descriptor:Endoplasmin, TETRAETHYLENE GLYCOL, PENTAETHYLENE GLYCOL
Authors:Dollins, D.E., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1YT2
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CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N APO CRYSTAL
Descriptor:Endoplasmin, TETRAETHYLENE GLYCOL
Authors:Dollins, D.E., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
2O1T
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STRUCTURE OF MIDDLE PLUS C-TERMINAL DOMAINS (M+C) OF GRP94
Descriptor:Endoplasmin
Authors:Dollins, D.E., Warren, J.J., Immormino, R.M., Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1U
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STRUCTURE OF FULL LENGTH GRP94 WITH AMP-PNP BOUND
Descriptor:Endoplasmin, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Dollins, D.E., Warren, J.J., Immormino, R.M., Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1V
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STRUCTURE OF FULL LENGTH GRP94 WITH ADP BOUND
Descriptor:Endoplasmin, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Dollins, D.E., Warren, J.J., Immormino, R.M., Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1W
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STRUCTURE OF N-TERMINAL PLUS MIDDLE DOMAINS (N+M) OF GRP94
Descriptor:Endoplasmin
Authors:Dollins, D.E., Warren, J.J., Immormino, R.M., Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
1R4I
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CRYSTAL STRUCTURE OF ANDROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO A DIRECT REPEAT RESPONSE ELEMENT
Descriptor:5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*TP*CP*AP*AP*GP*AP*AP*CP*AP*G)-3', 5'-D(*CP*TP*GP*TP*TP*CP*TP*TP*GP*AP*TP*GP*TP*TP*CP*TP*GP*G)-3', Androgen receptor, ...
Authors:Shaffer, P.L., Jivan, A., Dollins, D.E., Claessens, F., Gewirth, D.T.
Deposit date:2003-10-06
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis of androgen receptor binding to selective androgen response elements.
Proc.Natl.Acad.Sci.USA, 101, 2004
1TBW
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LIGAND INDUCED CONFORMATIONAL SHIFT IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION
Descriptor:Endoplasmin, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE, ...
Authors:Gewirth, D.T., Immormino, R.M., Dollins, D.E., Shaffer, P.L., Walker, M.A., Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1TC0
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LIGAND INDUCED CONFORMATIONAL SHIFTS IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION COMPLEXED WITH THE PHYSIOLOGICAL PARTNER ATP
Descriptor:Endoplasmin, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Gewirth, D.T., Immormino, R.M., Dollins, D.E., Shaffer, P.L., Walker, M.A., Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1TC6
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LIGAND INDUCED CONFORMATIONAL SHIFT IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION ADP-COMPLEX
Descriptor:Endoplasmin, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Gewirth, D.T., Immormino, R.M., Dollins, D.E., Shaffer, P.L., Walker, M.A., Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
4HNW
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THE NATA ACETYLTRANSFERASE COMPLEX BOUND TO INOSITOL HEXAKISPHOSPHATE
Descriptor:N-terminal acetyltransferase A complex subunit NAT1, N-terminal acetyltransferase A complex catalytic subunit ARD1, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Neubauer, J.L., Immormino, R.M., Dollins, D.E., Endo-Streeter, S.T., Pemble IV, C.W., York, J.D.
Deposit date:2012-10-21
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:The Protein Complex NatA Binds Inositol Hexakisphosphate and Exhibits Conformational Flexibility
To be Published
4HNX
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THE NATA ACETYLTRANSFERASE COMPLEX BOUND TO PPGPP
Descriptor:N-terminal acetyltransferase A complex subunit NAT1, N-terminal acetyltransferase A complex catalytic subunit ARD1, GUANOSINE-5',3'-TETRAPHOSPHATE
Authors:Neubauer, J.L., Immormino, R.M., Dollins, D.E., Endo-Streeter, S.T., Pemble IV, C.W., York, J.D.
Deposit date:2012-10-21
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.339 Å)
Cite:The Protein Complex NatA Binds Inositol Hexakisphosphate and Exhibits Conformational Flexibility
To be Published
4HNY
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APO N-TERMINAL ACETYLTRANSFERASE COMPLEX A
Descriptor:N-terminal acetyltransferase A complex subunit NAT1, N-terminal acetyltransferase A complex catalytic subunit ARD1, TETRAETHYLENE GLYCOL, ...
Authors:Neubauer, J.L., Immormino, R.M., Dollins, D.E., Endo-Streeter, S.T., Pemble IV, C.W., York, J.D.
Deposit date:2012-10-21
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.249 Å)
Cite:The Protein Complex NatA Binds Inositol Hexakisphosphate and Exhibits Conformational Flexibility
To be Published
2EXL
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GRP94 N-TERMINAL DOMAIN BOUND TO GELDANAMYCIN
Descriptor:Endoplasmin, GELDANAMYCIN, TETRAETHYLENE GLYCOL, ...
Authors:Reardon, P.N., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-11-08
Release date:2006-10-24
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
J.Mol.Biol., 388, 2009
2FXS
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YEAST HSP82 IN COMPLEX WITH THE NOVEL HSP90 INHIBITOR RADAMIDE
Descriptor:ATP-dependent molecular chaperone HSP82, METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE, GLYCEROL
Authors:Immormino, R.M., Gewirth, D.T.
Deposit date:2006-02-06
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
J.Mol.Biol., 388, 2009
2GFD
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GRP94 IN COMPLEX WITH THE NOVEL HSP90 INHIBITOR RADAMIDE
Descriptor:Endoplasmin, METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE, TETRAETHYLENE GLYCOL, ...
Authors:Immormino, R.M., Gewirth, D.T.
Deposit date:2006-03-21
Release date:2007-04-03
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
J.Mol.Biol., 388, 2009