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1HGA
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HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN
分子名称:HEMOGLOBIN (DEOXY) (ALPHA CHAIN), HEMOGLOBIN (DEOXY) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE
著者Liddington, R., Derewenda, Z., Dodson, E., Hubbard, R., Dodson, G.
登録日1991-10-31
公開日1994-01-31
最終更新日2014-11-19
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin.
J.Mol.Biol., 228, 1992
1HGB
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HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN
分子名称:HEMOGLOBIN (AQUO MET) (ALPHA CHAIN), HEMOGLOBIN (AQUO MET) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE
著者Liddington, R., Derewenda, Z., Dodson, E., Hubbard, R., Dodson, G.
登録日1991-10-31
公開日1994-01-31
最終更新日2012-10-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin.
J.Mol.Biol., 228, 1992
1HGC
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HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN
分子名称:HEMOGLOBIN (OXY) (ALPHA CHAIN), HEMOGLOBIN (DEOXY) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE, ...
著者Liddington, R., Derewenda, Z., Dodson, E., Hubbard, R., Dodson, G.
登録日1991-10-31
公開日1994-01-31
最終更新日2014-11-19
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin.
J.Mol.Biol., 228, 1992
2V25
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STRUCTURE OF THE CAMPYLOBACTER JEJUNI ANTIGEN PEB1A, AN ASPARTATE AND GLUTAMATE RECEPTOR WITH BOUND ASPARTATE
分子名称:MAJOR CELL-BINDING FACTOR, ASPARTIC ACID, ZINC ION
著者Muller, A., Dodson, E., del Rocio Leon-Kempis, M., Kelly, D.J., Wilkinson, A.J., Wilson, K.S.
登録日2007-06-01
公開日2007-06-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献A Bacterial Virulence Factor with a Dual Role as an Adhesin and a Solute Binding-Protein: The Crystal Structure at 1.5 A Resolution of the Peb1A Protein from the Food-Borne Human Pathogen Campylobacter Jejuni
J.Mol.Biol., 372, 2007
2WV7
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INTRACELLULAR SUBTILISIN PRECURSOR FROM B. CLAUSII
分子名称:INTRACELLULAR SUBTILISIN PROTEASE, SODIUM ION
著者Vevodova, J., Gamble, M., Ariza, A., Dodson, E., Jones, D.D., Wilson, K.S.
登録日2009-10-15
公開日2010-09-08
最終更新日2013-11-27
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal Structure of an Intracellular Subtilisin Reveals Novel Structural Features Unique to This Subtilisin Family.
Structure, 18, 2010
2WWT
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INTRACELLULAR SUBTILISIN PRECURSOR FROM B. CLAUSII
分子名称:INTRACELLULAR SUBTILISIN PROTEASE, SODIUM ION
著者Vevodova, J., Gamble, M., Ariza, A., Dodson, E., Jones, D.D., Wilson, K.S.
登録日2009-10-27
公開日2010-09-08
最終更新日2015-10-07
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Crystal Structure of an Intracellular Subtilisin Reveals Novel Structural Features Unique to This Subtilisin Family.
Structure, 18, 2010
2X8J
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INTRACELLULAR SUBTILISIN PRECURSOR FROM B. CLAUSII
分子名称:INTRACELLULAR SUBTILISIN PROTEASE, SODIUM ION, PENTAETHYLENE GLYCOL, ...
著者Vedodova, J., Gamble, M., Ariza, A., Dodson, E., Jones, D.D., Wilson, K.S.
登録日2010-03-09
公開日2010-08-11
最終更新日2019-09-25
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Crystal structure of an intracellular subtilisin reveals novel structural features unique to this subtilisin family.
Structure, 18, 2010
3K3W
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THERMOSTABLE PENICILLIN G ACYLASE FROM ALCALIGENES FAECALIS IN ORTHORHOMBIC FORM
分子名称:Penicillin G acylase, CALCIUM ION
著者Varshney, N.K., Kumar, R.S., Ignatova, Z., Dodson, E., Suresh, C.G.
登録日2009-10-05
公開日2009-11-10
最終更新日2012-03-14
実験手法X-RAY DIFFRACTION (3.31 Å)
主引用文献Crystallization and X-ray structure analysis of a thermostable penicillin G acylase from Alcaligenes faecalis
Acta Crystallogr.,Sect.F, 68, 2012
3ML0
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THERMOSTABLE PENICILLIN G ACYLASE FROM ALCALIGENES FAECALIS IN TETRAGONAL FORM
分子名称:Penicillin G acylase, alpha subunit, beta subunit, ...
著者Varshney, N.K., Kumar, R.S., Ignatova, Z., Dodson, E., Suresh, C.G.
登録日2010-04-16
公開日2010-05-05
最終更新日2012-03-14
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Crystallization and X-ray structure analysis of a thermostable penicillin G acylase from Alcaligenes faecalis
Acta Crystallogr.,Sect.F, 68, 2012
1ZNI
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INSULIN
分子名称:INSULIN, ZINC ION, CHLORIDE ION
著者Turkenburg, M.G.W., Whittingham, J.L., Dodson, G.G., Dodson, E.J., Xiao, B., Bentley, G.A.
登録日1997-09-23
公開日1998-01-28
最終更新日2018-07-04
実験手法X-RAY DIFFRACTION (1.498 Å)
主引用文献Structure of insulin in 4-zinc insulin.
Nature, 261, 1976
3ROV
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
分子名称:Insulin, PHENOL, ZINC ION, ...
著者Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
登録日2011-04-26
公開日2012-05-02
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
7INS
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STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z
分子名称:INSULIN (CHAIN A), INSULIN (CHAIN B), GENERAL PROTAMINE CHAIN, ...
著者Balschmidt, P., Hansen, F.B., Dodson, E., Dodson, G., Korber, F.
登録日1991-09-03
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of porcine insulin cocrystallized with clupeine Z.
Acta Crystallogr.,Sect.B, 47, 1991
2INS
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THE STRUCTURE OF DES-PHE B1 BOVINE INSULIN
分子名称:DES-PHE B1 INSULIN (CHAIN A), DES-PHE B1 INSULIN (CHAIN B), ZINC ION
著者Smith, G.D., Duax, W.L., Dodson, E.J., Dodson, G.G., Degraaf, R.A.G., Reynolds, C.D.
登録日1982-05-10
公開日1982-08-05
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Structure of Des-Phe B1 Bovine Insulin
Acta Crystallogr.,Sect.B, 38, 1982
4INS
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THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION
分子名称:INSULIN (CHAIN A), INSULIN (CHAIN B), ZINC ION
著者Dodson, G.G., Dodson, E.J., Hodgkin, D.C., Isaacs, N.W., Vijayan, M.
登録日1989-07-10
公開日1990-04-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The structure of 2Zn pig insulin crystals at 1.5 A resolution.
Philos.Trans.R.Soc.London,Ser.B, 319, 1988
1TGL
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A SERINE PROTEASE TRIAD FORMS THE CATALYTIC CENTRE OF A TRIACYLGLYCEROL LIPASE
分子名称:TRIACYL-GLYCEROL ACYLHYDROLASE
著者Brady, L., Brzozowski, A.M., Derewenda, Z.S., Dodson, E.J., Dodson, G.G., Tolley, S.P., Turkenburg, J.P., Christiansen, L., Huge-Jensen, B., Norskov, L., Thim, L.
登録日1990-02-05
公開日1990-10-15
最終更新日2012-02-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A serine protease triad forms the catalytic centre of a triacylglycerol lipase.
Nature, 343, 1990
3P2X
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIARAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
分子名称:Insulin, ZINC ION, CHLORIDE ION, ...
著者Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
登録日2010-10-04
公開日2011-11-23
最終更新日2014-10-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIRAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
分子名称:Insulin, PHENOL, ZINC ION, ...
著者Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
登録日2010-10-04
公開日2011-11-23
最終更新日2014-10-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3JSD
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
分子名称:Insulin A chain, Insulin B chain, ZINC ION, ...
著者Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
登録日2009-09-10
公開日2010-09-15
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3TGL
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STRUCTURE AND MOLECULAR MODEL REFINEMENT OF RHIZOMUCOR MIEHEI TRIACYLGLYCERIDE LIPASE: A CASE STUDY OF THE USE OF SIMULATED ANNEALING IN PARTIAL MODEL REFINEMENT
分子名称:TRIACYL-GLYCEROL ACYLHYDROLASE
著者Brady, L., Brzozowski, A.M., Derewenda, Z.S., Dodson, E.J., Dodson, G.G., Tolley, S.P., Turkenburg, J.P., Christiansen, L., Huge-Jensen, B., Norskov, L., Thim, L.
登録日1991-07-29
公開日1993-07-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献STRUCTURE AND MOLECULAR-MODEL REFINEMENT OF RHIZOMUCOR-MIEHEI TRIACYLGLYCERIDE LIPASE - A CASE-STUDY OF THE USE OF SIMULATED ANNEALING IN PARTIAL MODEL REFINEMENT.
Acta Crystallogr.,Sect.B, 48, 1992
1G7A
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1.2 A STRUCTURE OF T3R3 HUMAN INSULIN AT 100 K
分子名称:INSULIN A-CHAIN, INSULIN B-CHAIN, ZINC ION, ...
著者Smith, G.D., Pangborn, W.A., Blessing, R.H.
登録日2000-11-09
公開日2001-08-03
最終更新日2019-11-20
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Phase changes in T(3)R(3)(f) human insulin: temperature or pressure induced?
Acta Crystallogr.,Sect.D, 57, 2001
1G7B
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1.3 A STRUCTURE OF T3R3 HUMAN INSULIN AT 100 K
分子名称:INSULIN A-CHAIN, INSULIN B-CHAIN, ZINC ION, ...
著者Smith, G.D., Pangborn, W.A., Blessing, R.H.
登録日2000-11-09
公開日2001-08-03
最終更新日2019-11-20
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Phase changes in T(3)R(3)(f) human insulin: temperature or pressure induced?
Acta Crystallogr.,Sect.D, 57, 2001
3BXQ
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THE STRUCTURE OF A MUTANT INSULIN UNCOUPLES RECEPTOR BINDING FROM PROTEIN ALLOSTERY. AN ELECTROSTATIC BLOCK TO THE TR TRANSITION
分子名称:insulin A chain, insulin B chain, ZINC ION
著者Wan, Z.L., Huang, K., Hu, S.Q., Whittaker, J., Weiss, M.A.
登録日2008-01-14
公開日2008-05-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
3GKY
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THE STRUCTURAL BASIS OF AN ER STRESS-ASSOCIATED BOTTLENECK IN A PROTEIN FOLDING LANDSCAPE
分子名称:Insulin A chain, Insulin B chain, ZINC ION, ...
著者Liu, M., Wan, Z.L., Chu, Y.C., Alddin, H., Klaproth, B., Weiss, M.A.
登録日2009-03-11
公開日2009-03-24
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY.
J.Biol.Chem., 284, 2009
3KQ6
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ENHANCING THE THERAPEUTIC PROPERTIES OF A PROTEIN BY A DESIGNED ZINC-BINDING SITE, STRUCTURAL PRINCIPLES OF A NOVEL LONG-ACTING INSULIN ANALOG
分子名称:Insulin A chain, Insulin B chain, ZINC ION, ...
著者Wan, Z.L., Hu, S.Q., Whittaker, L., Phillips, N.B., Whittake, J., Ismail-Beigi, F., Weiss, M.A.
登録日2009-11-17
公開日2010-02-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
3V19
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
分子名称:Insulin, ZINC ION, CHLORIDE ION, ...
著者Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
登録日2011-12-09
公開日2012-12-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
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