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1JBU
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COAGULATION FACTOR VII ZYMOGEN (EGF2/PROTEASE) IN COMPLEX WITH INHIBITORY EXOSITE PEPTIDE A-183
Descriptor:COAGULATION FACTOR VII, Peptide exosite inhibitor A-183, SULFATE ION, ...
Authors:Eigenbrot, C., Kirchhofer, D., Dennis, M.S., Santell, L., Lazarus, R.A., Stamos, J., Ultsch, M.H.
Deposit date:2001-06-06
Release date:2001-07-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:The factor VII zymogen structure reveals reregistration of beta strands during activation.
Structure, 9, 2001
1N4Y
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REFINED STRUCTURE OF KISTRIN
Descriptor:KISTRIN
Authors:Krezel, A.M., Krane, J., Dennis, M.S., Lazarus, R.A., Wagner, G.
Deposit date:2002-11-02
Release date:2003-01-28
Last modified:2012-09-05
Method:SOLUTION NMR
Cite:Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist.
Science, 253, 1991
1DVA
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE PEPTIDE EXOSITE INHIBITOR E-76 AND COAGULATION FACTOR VIIA
Descriptor:DES-GLA FACTOR VIIA (HEAVY CHAIN), DES-GLA FACTOR VIIA (LIGHT CHAIN), PEPTIDE E-76, ...
Authors:Eigenbrot, C., Ultsch, M.H.
Deposit date:2000-01-20
Release date:2000-05-12
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Peptide exosite inhibitors of factor VIIa as anticoagulants.
Nature, 404, 2000
3HR5
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M1PRIME PEPTIDE FROM IGE BOUND BY HUMANIZED ANTIBODY 47H4 FAB
Descriptor:Fab h47H4 light chain, Fab h47H4 heavy chain, M1prime-derived peptide, ...
Authors:Eigenbrot, C.W., Ultsch, M.H.
Deposit date:2009-06-08
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice.
J.Clin.Invest., 120, 2010
4K3J
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CRYSTAL STRUCTURE OF ONARTUZUMAB FAB IN COMPLEX WITH MET AND HGF-BETA
Descriptor:Hepatocyte growth factor, Hepatocyte growth factor beta chain, Onartuzumab Fab heavy chain, ...
Authors:Ma, X., Starovasnik, M.A.
Deposit date:2013-04-10
Release date:2013-08-28
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.
Proc.Natl.Acad.Sci.USA, 110, 2013
6O1F
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COMPLEX BETWEEN SOYBEAN TRYPSIN INHIBITOR BETA1-TRYPTASE AND A HUMANIZED FAB
Descriptor:Tryptase alpha/beta-1, Heavy Chain hu31A.v11, Trypsin inhibitor A, ...
Authors:Ultsch, M.H., Yi, T.
Deposit date:2019-02-19
Release date:2019-10-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell, 179, 2019