Summary for 1N4Y
| Entry DOI | 10.2210/pdb1n4y/pdb |
| Related | 1kst |
| Descriptor | KISTRIN (1 entity in total) |
| Functional Keywords | beta, venom, blood coagulation, rgd, blood clotting |
| Biological source | Calloselasma rhodostoma (Malayan pit viper) |
| Cellular location | Secreted: P30403 |
| Total number of polymer chains | 1 |
| Total formula weight | 7341.36 |
| Authors | Krezel, A.M.,Krane, J.,Dennis, M.S.,Lazarus, R.A.,Wagner, G. (deposition date: 2002-11-02, release date: 2003-01-28, Last modification date: 2024-11-13) |
| Primary citation | Adler, M.,Lazarus, R.A.,Dennis, M.S.,Wagner, G. Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist. Science, 253:445-448, 1991 Cited by PubMed Abstract: The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein. PubMed: 1862345PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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