Author results

5ICD
  • Download 5icd
  • View 5icd
Molmil generated image of 5icd
REGULATION OF AN ENZYME BY PHOSPHORYLATION AT THE ACTIVE SITE
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID
Authors:Hurley, J.H., Dean, A.M., Sohl, J.L., Koshlandjunior, D.E., Stroud, R.M.
Deposit date:1990-05-30
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Regulation of an enzyme by phosphorylation at the active site.
Science, 249, 1990
9ICD
  • Download 9icd
  • View 9icd
Molmil generated image of 9icd
CATALYTIC MECHANISM OF NADP+-DEPENDENT ISOCITRATE DEHYDROGENASE: IMPLICATIONS FROM THE STRUCTURES OF MAGNESIUM-ISOCITRATE AND NADP+ COMPLEXES
Descriptor:ISOCITRATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Hurley, J.H., Dean, A.M., Koshland Jr., D.E., Stroud, R.M.
Deposit date:1991-07-29
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes.
Biochemistry, 30, 1991
6ICD
  • Download 6icd
  • View 6icd
Molmil generated image of 6icd
REGULATION OF AN ENZYME BY PHOSPHORYLATION AT THE ACTIVE SITE
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Hurley, J.H., Dean, A.M., Sohl, J.L., Koshlandjunior, D.E., Stroud, R.M.
Deposit date:1990-05-30
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulation of an enzyme by phosphorylation at the active site.
Science, 249, 1990
7ICD
  • Download 7icd
  • View 7icd
Molmil generated image of 7icd
REGULATION OF AN ENZYME BY PHOSPHORYLATION AT THE ACTIVE SITE
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Hurley, J.H., Dean, A.M., Sohl, J.L., Koshlandjunior, D.E., Stroud, R.M.
Deposit date:1990-05-30
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Regulation of an enzyme by phosphorylation at the active site.
Science, 249, 1990
8ICD
  • Download 8icd
  • View 8icd
Molmil generated image of 8icd
REGULATION OF AN ENZYME BY PHOSPHORYLATION AT THE ACTIVE SITE
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID
Authors:Hurley, J.H., Dean, A.M., Sohl, J.L., Koshlandjunior, D.E., Stroud, R.M.
Deposit date:1990-05-30
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Regulation of an enzyme by phosphorylation at the active site.
Science, 249, 1990
4ICD
  • Download 4icd
  • View 4icd
Molmil generated image of 4icd
REGULATION OF ISOCITRATE DEHYDROGENASE BY PHOSPHORYLATION INVOLVES NO LONG-RANGE CONFORMATIONAL CHANGE IN THE FREE ENZYME
Descriptor:PHOSPHORYLATED ISOCITRATE DEHYDROGENASE
Authors:Hurley, J.H., Dean, A.M., Thorsness, P.E., Koshlandjunior, D.E., Stroud, R.M.
Deposit date:1989-12-28
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme.
J.Biol.Chem., 265, 1990
4AJ3
  • Download 4aj3
  • View 4aj3
Molmil generated image of 4aj3
3D STRUCTURE OF E. COLI ISOCITRATE DEHYDROGENASE IN COMPLEX WITH ISOCITRATE, CALCIUM(II) AND NADP - THE PSEUDO-MICHAELIS COMPLEX
Descriptor:NADP ISOCITRATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRIC ACID, ...
Authors:Goncalves, S., Miller, S.P., Carrondo, M.A., Dean, A.M., Matias, P.M.
Deposit date:2012-02-15
Release date:2012-10-31
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase.
Biochemistry, 51, 2012
4AJA
  • Download 4aja
  • View 4aja
Molmil generated image of 4aja
3D STRUCTURE OF E. COLI ISOCITRATE DEHYDROGENASE IN COMPLEX WITH ISOCITRATE, CALCIUM(II) AND THIONADP
Descriptor:NADP ISOCITRATE DEHYDROGENASE, 7-THIONICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRIC ACID, ...
Authors:Goncalves, S., Miller, S.P., Carrondo, M.A., Dean, A.M., Matias, P.M.
Deposit date:2012-02-16
Release date:2012-10-31
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase.
Biochemistry, 51, 2012
4AJB
  • Download 4ajb
  • View 4ajb
Molmil generated image of 4ajb
3D STRUCTURE OF E. COLI ISOCITRATE DEHYDROGENASE K100M MUTANT IN COMPLEX WITH ISOCITRATE, MAGNESIUM(II) AND THIONADP
Descriptor:NADP ISOCITRATE DEHYDROGENASE, 7-THIONICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRIC ACID, ...
Authors:Goncalves, S., Miller, S.P., Carrondo, M.A., Dean, A.M., Matias, P.M.
Deposit date:2012-02-16
Release date:2012-10-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase.
Biochemistry, 51, 2012
4AJC
  • Download 4ajc
  • View 4ajc
Molmil generated image of 4ajc
3D STRUCTURE OF E. COLI ISOCITRATE DEHYDROGENASE K100M MUTANT IN COMPLEX WITH ALPHA-KETOGLUTARATE, CALCIUM(II) AND ADENINE NUCLEOTIDE PHOSPHATE
Descriptor:NADP ISOCITRATE DEHYDROGENASE, ADENOSINE-2'-5'-DIPHOSPHATE, 2-OXOGLUTARIC ACID, ...
Authors:Goncalves, S., Miller, S.P., Carrondo, M.A., Dean, A.M., Matias, P.M.
Deposit date:2012-02-16
Release date:2012-10-31
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase.
Biochemistry, 51, 2012
4AJR
  • Download 4ajr
  • View 4ajr
Molmil generated image of 4ajr
3D STRUCTURE OF E. COLI ISOCITRATE DEHYDROGENASE K100M MUTANT IN COMPLEX WITH ALPHA-KETOGLUTARATE, MAGNESIUM(II) AND NADPH - THE PRODUCT COMPLEX
Descriptor:ISOCITRATE DEHYDROGENASE [NADP], BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Goncalves, S., Miller, S.P., Carrondo, M.A., Dean, A.M., Matias, P.M.
Deposit date:2012-02-17
Release date:2012-10-31
Method:X-RAY DIFFRACTION (2.687 Å)
Cite:Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase.
Biochemistry, 51, 2012
4AJS
  • Download 4ajs
  • View 4ajs
Molmil generated image of 4ajs
3D STRUCTURE OF E. COLI ISOCITRATE DEHYDROGENASE K100M MUTANT IN COMPLEX WITH ISOCITRATE, MAGNESIUM(II), ADENOSINE 2',5'-BIPHOSPHATE AND RIBOSYLNICOTINAMIDE-5'-PHOSPHATE
Descriptor:ISOCITRATE DEHYDROGENASE [NADP], ADENOSINE-2'-5'-DIPHOSPHATE, ISOCITRIC ACID, ...
Authors:Goncalves, S., Miller, S.P., Carrondo, M.A., Dean, A.M., Matias, P.M.
Deposit date:2012-02-17
Release date:2012-10-31
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase.
Biochemistry, 51, 2012
4BNP
  • Download 4bnp
  • View 4bnp
Molmil generated image of 4bnp
3D STRUCTURE OF E. COLI ISOCITRATE DEHYDROGENASE K100M MUTANT IN COMPLEX WITH ISOCITRATE AND MAGNESIUM(II)
Descriptor:ISOCITRATE DEHYDROGENASE [NADP], ISOCITRIC ACID, MAGNESIUM ION, ...
Authors:Miller, S.P., Goncalves, S., Matias, P.M., Dean, A.M.
Deposit date:2013-05-16
Release date:2014-05-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Evolution of a Transition State: Role of Lys100 in the Active Site of Isocitrate Dehydrogenase.
Chembiochem, 15, 2014
1GRO
  • Download 1gro
  • View 1gro
Molmil generated image of 1gro
REGULATORY AND CATALYTIC MECHANISMS IN ESCHERICHIA COLI ISOCITRATE DEHYDROGENASE: MULTIPLE ROLES FOR N115
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID
Authors:Grobler, J.A., Hurley, J.H.
Deposit date:1995-10-12
Release date:1996-04-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Second-site suppression of regulatory phosphorylation in Escherichia coli isocitrate dehydrogenase.
Protein Sci., 5, 1996
1GRP
  • Download 1grp
  • View 1grp
Molmil generated image of 1grp
REGULATORY AND CATALYTIC MECHANISMS IN ESCHERICHIA COLI ISOCITRATE DEHYDROGENASE: MULTIPLE ROLES FOR N115
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID
Authors:Grobler, J.A., Hurley, J.H.
Deposit date:1995-10-12
Release date:1996-04-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Second-site suppression of regulatory phosphorylation in Escherichia coli isocitrate dehydrogenase.
Protein Sci., 5, 1996
1BL5
  • Download 1bl5
  • View 1bl5
Molmil generated image of 1bl5
ISOCITRATE DEHYDROGENASE FROM E. COLI SINGLE TURNOVER LAUE STRUCTURE OF RATE-LIMITED PRODUCT COMPLEX, 10 MSEC TIME RESOLUTION
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, 2-OXOGLUTARIC ACID, ...
Authors:Stoddard, B.L., Cohen, B., Brubaker, M., Mesecar, A., Koshland Junior, D.E.
Deposit date:1998-07-23
Release date:1999-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Millisecond Laue structures of an enzyme-product complex using photocaged substrate analogs.
Nat.Struct.Biol., 5, 1998
1IDC
  • Download 1idc
  • View 1idc
Molmil generated image of 1idc
ISOCITRATE DEHYDROGENASE FROM E.COLI (MUTANT K230M), STEADY-STATE INTERMEDIATE COMPLEX DETERMINED BY LAUE CRYSTALLOGRAPHY
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, 2-OXALOSUCCINIC ACID
Authors:Bolduc, J.M., Dyer, D.H., Scott, W.G., Singer, P., Sweet, R.M., Koshland Junior, D.E., Stoddard, B.L.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
1IDD
  • Download 1idd
  • View 1idd
Molmil generated image of 1idd
ISOCITRATE DEHYDROGENASE Y160F MUTANT APO ENZYME
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Lee, M.E., Dyer, D.H., Klein, O.D., Bolduc, J.M., Stoddard, B.L., Koshland Junior, D.E.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
1IDE
  • Download 1ide
  • View 1ide
Molmil generated image of 1ide
ISOCITRATE DEHYDROGENASE Y160F MUTANT STEADY-STATE INTERMEDIATE COMPLEX (LAUE DETERMINATION)
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID, ...
Authors:Bolduc, J.M., Dyer, D.H., Scott, W.G., Singer, P., Sweet, R.M., Koshland Junior, D.E., Stoddard, B.L.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
1IDF
  • Download 1idf
  • View 1idf
Molmil generated image of 1idf
ISOCITRATE DEHYDROGENASE K230M MUTANT APO ENZYME
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Bolduc, J.M., Dyer, D.H., Scott, W.G., Singer, P., Sweet, R.M., Koshland Junior, D.E., Stoddard, B.L.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
1HEX
  • Download 1hex
  • View 1hex
Molmil generated image of 1hex
STRUCTURE OF 3-ISOPROPYLMALATE DEHYDROGENASE IN COMPLEX WITH NAD+: LIGAND-INDUCED LOOP-CLOSING AND MECHANISM FOR COFACTOR SPECIFICITY
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Hurley, J.H.
Deposit date:1994-09-09
Release date:1994-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of 3-isopropylmalate dehydrogenase in complex with NAD+: ligand-induced loop closing and mechanism for cofactor specificity.
Structure, 2, 1994
1ISO
  • Download 1iso
  • View 1iso
Molmil generated image of 1iso
ISOCITRATE DEHYDROGENASE: STRUCTURE OF AN ENGINEERED NADP+--> NAD+ SPECIFICITY-REVERSAL MUTANT
Descriptor:ISOCITRATE DEHYDROGENASE, SULFATE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Hurley, J.H.
Deposit date:1996-03-01
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Determinants of cofactor specificity in isocitrate dehydrogenase: structure of an engineered NADP+ --> NAD+ specificity-reversal mutant.
Biochemistry, 35, 1996
1SJS
  • Download 1sjs
  • View 1sjs
Molmil generated image of 1sjs
ACCESS TO PHOSPHORYLATION IN ISOCITRATE DEHYDROGENASE MAY OCCUR BY DOMAIN SHIFTING
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Finer-Moore, J., Stroud, R.M.
Deposit date:1997-07-08
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting.
Biochemistry, 36, 1997
3ICD
  • Download 3icd
  • View 3icd
Molmil generated image of 3icd
STRUCTURE OF A BACTERIAL ENZYME REGULATED BY PHOSPHORYLATION, ISOCITRATE DEHYDROGENASE
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Hurley, J.H., Thorsness, P.E., Ramalingam, V., Helmers, N.H., Koshlandjunior, D.E., Stroud, R.M.
Deposit date:1989-12-28
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase.
Proc.Natl.Acad.Sci.USA, 86, 1989
1AI2
  • Download 1ai2
  • View 1ai2
Molmil generated image of 1ai2
ISOCITRATE DEHYDROGENASE COMPLEXED WITH ISOCITRATE, NADP+, AND CALCIUM (FLASH-COOLED)
Descriptor:ISOCITRATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRATE CALCIUM COMPLEX
Authors:Stoddard, B.L., Mesecar, A., Koshland Junior, D.E.
Deposit date:1997-04-30
Release date:1997-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences.
Science, 277, 1997
<12>