Author results

6I9B
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NMR STRUCTURE OF THE LA MODULE FROM HUMAN LARP4A
Descriptor:La-related protein 4
Authors:Conte, M.R., Martino, L., Atkinson, R.A., Kelly, G., Cruz-Gallardo, i., De Tito, S., Trotta, R.
Deposit date:2018-11-22
Release date:2019-03-13
Last modified:2019-07-03
Method:SOLUTION NMR
Cite:LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA.
Nucleic Acids Res., 47, 2019
6I5G
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X-RAY STRUCTURE OF HUMAN SOLUBLE EPOXIDE HYDROLASE C-TERMINAL DOMAIN (HSEH CTD)IN COMPLEX WITH 15D-PGJ2
Descriptor:Bifunctional epoxide hydrolase 2, 1,2-ETHANEDIOL, (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid
Authors:Abis, G., Kopec, J., Yue, W.W., Conte, M.R.
Deposit date:2018-11-13
Release date:2019-05-29
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:15-deoxy-Delta12,14-Prostaglandin J2inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.
Commun Biol, 2, 2019
6I5E
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X-RAY STRUCTURE OF APO HUMAN SOLUBLE EPOXIDE HYDROLASE C-TERMINAL DOMAIN (HSEH CTD)
Descriptor:Bifunctional epoxide hydrolase 2
Authors:Abis, G., Kopec, J., Yue, W.W., Conte, M.R.
Deposit date:2018-11-13
Release date:2019-05-29
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:15-deoxy-Delta12,14-Prostaglandin J2inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.
Commun Biol, 2, 2019
6GJ4
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TUBULIN-6J COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Brindisi, M., Ulivieri, C., Alfano, G., Gemma, S., Balaguer, F.d.A., Khan, T., Grillo, A., Chemi, G., Menchon, G., Prota, A.E., Olieric, N., Agell, D.L., Barasoain, I., Diaz, J.F., Nebbioso, A., Conte, M.R., Lopresti, L., Magnano, S., Amet, R., Kinsella, P., Zisterer, D.M., Ibrahim, O., O'Sullivan, J., Morbidelli, L., Spaccapelo, R., Baldari, C., Butini, S., Novellino, E., Campiani, G., Altucci, L., Steinmetz, M.O., Brogi, S.
Deposit date:2018-05-16
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.
Eur J Med Chem, 162, 2018
5O90
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CRYSTAL STRUCTURE OF A P38ALPHA T185G MUTANT IN COMPLEX WITH TAB1 PEPTIDE.
Descriptor:Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE
Authors:Nichols, C.E., De Nicola, G.F., Thapa, D.
Deposit date:2017-06-15
Release date:2018-01-31
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:TAB1-Induced Autoactivation of p38 alpha Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185.
Mol. Cell. Biol., 38, 2018
5IFM
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HUMAN NONO (P54NRB) HOMODIMER
Descriptor:Non-POU domain-containing octamer-binding protein, CHLORIDE ION, PROLINE, ...
Authors:Knott, G.J., Bond, C.S.
Deposit date:2016-02-26
Release date:2016-11-09
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A crystallographic study of human NONO (p54(nrb)): overcoming pathological problems with purification, data collection and noncrystallographic symmetry.
Acta Crystallogr D Struct Biol, 72, 2016
4LOQ
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STRUCTURAL BASIS OF AUTOACTIVATION OF P38 ALPHA INDUCED BY TAB1 (TETRAGONAL CRYSTAL FORM WITH BOUND SULPHATE)
Descriptor:Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, ...
Authors:Chaikuad, A., DeNicola, G.F., Yue, W.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Marber, M.S., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-07-13
Release date:2013-08-21
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.319 Å)
Cite:Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1.
Nat.Struct.Mol.Biol., 20, 2013
4LOP
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STRUCTURAL BASIS OF AUTOACTIVATION OF P38 ALPHA INDUCED BY TAB1 (TETRAGONAL CRYSTAL FORM)
Descriptor:Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, ...
Authors:Chaikuad, A., DeNicola, G.F., Krojer, T., Allerston, C.K., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Marber, M.S., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-07-13
Release date:2013-08-21
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.049 Å)
Cite:Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1.
Nat.Struct.Mol.Biol., 20, 2013
4LOO
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STRUCTURAL BASIS OF AUTOACTIVATION OF P38 ALPHA INDUCED BY TAB1 (MONOCLINIC CRYSTAL FORM)
Descriptor:Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE
Authors:Chaikuad, A., DeNicola, G.F., Krojer, T., Allerston, C.K., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Marber, M.S., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-07-13
Release date:2013-08-21
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1.
Nat.Struct.Mol.Biol., 20, 2013
4CPG
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SOLUTION STRUCTURE OF THE SGTA N-TERMINAL DOMAIN
Descriptor:SMALL GLUTAMINE-RICH TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN ALPHA
Authors:Darby, J.F., Krysztofinska, E.M., Simpson, P.J., Isaacson, R.L.
Deposit date:2014-02-06
Release date:2014-12-03
Last modified:2018-02-14
Method:SOLUTION NMR
Cite:Solution Structure of the Sgta Dimerisation Domain and Investigation of its Interactions with the Ubiquitin-Like Domains of Bag6 and Ubl4A.
Plos One, 9, 2014
3PKN
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CRYSTAL STRUCTURE OF MLLE DOMAIN OF POLY(A) BINDING PROTEIN IN COMPLEX WITH PAM2 MOTIF OF LA-RELATED PROTEIN 4 (LARP4)
Descriptor:Polyadenylate-binding protein 1, La-related protein 4, SULFATE ION, ...
Authors:Xie, J., Kozlov, G., Gehring, K.
Deposit date:2010-11-11
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:La-Related Protein 4 Binds Poly(A), Interacts with the Poly(A)-Binding Protein MLLE Domain via a Variant PAM2w Motif, and Can Promote mRNA Stability.
Mol.Cell.Biol., 31, 2011
2VOP
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAINS OF HUMAN LA PROTEIN COMPLEXED WITH RNA OLIGOMER AUUUU
Descriptor:LUPUS LA PROTEIN, 5'-R(*AP*UP*UP*UP*UP)-3', SULFATE ION
Authors:Kotik-Kogan, O., Valentine, E.R., Sanfelice, D., Conte, M.R., Curry, S.
Deposit date:2008-02-19
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
2VOO
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAINS OF HUMAN LA PROTEIN COMPLEXED WITH RNA OLIGOMER UUUUUUUU
Descriptor:LUPUS LA PROTEIN, 5'-R(*UP*UP*UP*UP*UP*UP*UP)-3'
Authors:Kotik-Kogan, O., Valentine, E.R., Sanfelice, D., Conte, M.R., Curry, S.
Deposit date:2008-02-19
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
2VON
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAINS OF HUMAN LA PROTEIN COMPLEXED WITH RNA OLIGOMER AUAAUUU
Descriptor:LUPUS LA PROTEIN, 5'-R(*AP*UP*AP*AP*UP*UP*UP)-3'
Authors:Kotik-Kogan, O., Valentine, E.R., Sanfelice, D., Conte, M.R., Curry, S.
Deposit date:2008-02-19
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
2VOD
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAINS OF HUMAN LA PROTEIN COMPLEXED WITH RNA OLIGOMER AUAUUUU
Descriptor:LUPUS LA PROTEIN, 5'-R(*AP*UP*AP*UP*UP*UP*UP)-3'
Authors:Kotik-Kogan, O., Valentine, E.R., Sanfelice, D., Conte, M.R., Curry, S.
Deposit date:2008-02-15
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
2MTG
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SOLUTION STRUCTURE OF THE RRM1 OF HUMAN LARP6
Descriptor:La-related protein 6
Authors:Martino, L., Atkinson, A.R., Kelly, G., Conte, M.R.
Deposit date:2014-08-18
Release date:2014-12-24
Last modified:2015-01-28
Method:SOLUTION NMR
Cite:Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.
Nucleic Acids Res., 43, 2015
2MTF
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SOLUTION STRUCTURE OF THE LA MOTIF OF HUMAN LARP6
Descriptor:La-related protein 6
Authors:Martino, L., Salisbury, N.JH., Atkinson, A.R., Kelly, G., Conte, M.R.
Deposit date:2014-08-18
Release date:2014-12-24
Last modified:2015-01-28
Method:SOLUTION NMR
Cite:Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.
Nucleic Acids Res., 43, 2015
2L8K
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NMR STRUCTURE OF THE ARTERIVIRUS NONSTRUCTURAL PROTEIN 7 ALPHA (NSP7 ALPHA)
Descriptor:Non-structural protein 7
Authors:Conte, M.R., Gaudin, C., Manolaridis, I., Tucker, P.W., Kelly, G.
Deposit date:2011-01-19
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7{alpha}.
J.Virol., 85, 2011
2KFW
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SOLUTION STRUCTURE OF FULL-LENGTH SLYD FROM E.COLI
Descriptor:FKBP-type peptidyl-prolyl cis-trans isomerase slyD
Authors:Martino, L., He, Y., Hands-Taylor, K.L., Valentine, E.R., Kelly, G., Giancola, C., Conte, M.R.
Deposit date:2009-02-28
Release date:2009-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The interaction of the Escherichia coli protein SlyD with nickel ions illuminates the mechanism of regulation of its peptidyl-prolyl isomerase activity.
Febs J., 276, 2009
2G2K
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NMR STRUCTURE OF AN N-TERMINAL FRAGMENT OF THE EUKARYOTIC INITIATION FACTOR 5 (EIF5)
Descriptor:Eukaryotic translation initiation factor 5
Authors:Conte, M.R., Kelly, G., Babon, J., Sanfelice, D., Smerdon, S.J., Proud, C.G.
Deposit date:2006-02-16
Release date:2006-06-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors
Biochemistry, 45, 2006
1SJR
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NMR STRUCTURE OF RRM2 FROM HUMAN POLYPYRIMIDINE TRACT BINDING PROTEIN ISOFORM 1 (PTB1)
Descriptor:Polypyrimidine tract-binding protein 1
Authors:Simpson, P.J., Monie, T.P., Szendroi, A., Davydova, N., Tyzack, J.K., Conte, M.R., Read, C.M., Cary, P.D., Svergun, D.I., Konarev, P.V., Petoukhov, M.V., Curry, S., Matthews, S.J.
Deposit date:2004-03-04
Release date:2004-09-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and RNA Interactions of the N-Terminal RRM Domains of PTB
Structure, 12, 2004
1SJQ
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NMR STRUCTURE OF RRM1 FROM HUMAN POLYPYRIMIDINE TRACT BINDING PROTEIN ISOFORM 1 (PTB1)
Descriptor:Polypyrimidine tract-binding protein 1
Authors:Simpson, P.J., Monie, T.P., Szendroi, A., Davydova, N., Tyzack, J.K., Conte, M.R., Read, C.M., Cary, P.D., Svergun, D.I., Konarev, P.V., Petoukhov, M.V., Curry, S., Matthews, S.J.
Deposit date:2004-03-04
Release date:2004-09-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and RNA Interactions of the N-Terminal RRM Domains of PTB
Structure, 12, 2004
1SAA
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ATF-2 RECOGNITION SITE, NMR, 10 STRUCTURES
Descriptor:DNA (5'-D(*CP*AP*TP*GP*TP*GP*AP*CP*GP*TP*CP*AP*CP*AP*TP*G)-3')
Authors:Conte, M.R., Lane, A.N., Bloomberg, G.
Deposit date:1997-08-19
Release date:1997-11-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the ATF-2 recognition site and its interaction with the ATF-2 peptide.
Nucleic Acids Res., 25, 1997
1S7A
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NMR STRUCTURE OF THE LA MOTIF OF HUMAN LA PROTEIN
Descriptor:Lupus La protein
Authors:Alfano, C., Sanfelice, D., Babon, J., Kelly, G., Jacks, A., Curry, S., Conte, M.R.
Deposit date:2004-01-29
Release date:2004-04-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.
Nat.Struct.Mol.Biol., 11, 2004
1S79
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SOLUTION STRUCTURE OF THE CENTRAL RRM OF HUMAN LA PROTEIN
Descriptor:Lupus La protein
Authors:Alfano, C., Sanfelice, D., Babon, J., Kelly, G., Jacks, A., Curry, S., Conte, M.R.
Deposit date:2004-01-29
Release date:2004-04-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.
Nat.Struct.Mol.Biol., 11, 2004
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