6I5G

X-ray structure of human soluble Epoxide Hydrolase C-terminal Domain (hsEH CTD)in complex with 15d-PGJ2

Summary for 6I5G

Entry DOI	10.2210/pdb6i5g/pdb
Descriptor	Bifunctional epoxide hydrolase 2, 1,2-ETHANEDIOL, (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid, ... (4 entities in total)
Functional Keywords	hseh ctd, apoprotein, alpha_beta hydrolase fold, 15d-pgj2, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	80468.19
Authors	Abis, G.,Kopec, J.,Yue, W.W.,Conte, M.R. (deposition date: 2018-11-13, release date: 2019-05-29, Last modification date: 2024-01-24)
Primary citation	Abis, G.,Charles, R.L.,Kopec, J.,Yue, W.W.,Atkinson, R.A.,Bui, T.T.T.,Lynham, S.,Popova, S.,Sun, Y.B.,Fraternali, F.,Eaton, P.,Conte, M.R. 15-deoxy-Delta12,14-Prostaglandin J2inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism. Commun Biol, 2:188-188, 2019 Cited by PubMed: 31123712 DOI: 10.1038/s42003-019-0426-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation