1TYE | | STRUCTURAL BASIS FOR ALLOSTERY IN INTEGRINS AND BINDING OF LIGAND-MIMETIC THERAPEUTICS TO THE PLATELET RECEPTOR FOR FIBRINOGEN | | Descriptor: | Integrin alpha-IIb, Integrin beta-3, CALCIUM ION, ... | | Authors: | Xiao, T., Takagi, J., Coller, B.S., Wang, J.-H., Springer, T.A. | | Deposit date: | 2004-07-07 | | Release date: | 2004-10-12 | | Last modified: | 2014-09-10 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
Nature, 432, 2004
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4CAK | | THREE-DIMENSIONAL RECONSTRUCTION OF INTACT HUMAN INTEGRIN ALPHAIIBBETA3 IN A PHOSPHOLIPID BILAYER NANODISC | | Descriptor: | Integrin alpha-IIb, Integrin beta-3, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Choi, W.S., Rice, W.J., Stokes, D.L., Coller, B.S. | | Deposit date: | 2013-10-08 | | Release date: | 2013-10-30 | | Last modified: | 2019-09-11 | | Method: | ELECTRON MICROSCOPY (20.5 Å) | | Cite: | Three-Dimensional Reconstruction of Intact Human Integrin Alphaiibbeta3; New Implications for Activation-Dependent Ligand Binding.
Blood, 122, 2013
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6V4P | | STRUCTURE OF THE INTEGRIN ALPHAIIBBETA3-ABCIXIMAB COMPLEX | | Descriptor: | Integrin alpha-IIb, Integrin beta-3, Abciximab, ... | | Authors: | Nesic, D., Zhang, Y., Spasic, A., Li, J., Provasi, D., Filizola, M., Walz, T., Coller, B.S. | | Deposit date: | 2019-11-28 | | Release date: | 2020-02-05 | | Last modified: | 2020-03-11 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-Electron Microscopy Structure of the alpha IIb beta 3-Abciximab Complex.
Arterioscler Thromb Vasc Biol., 40, 2020
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3NID | | THE CLOSED HEADPIECE OF INTEGRIN ALPHAIIB BETA3 AND ITS COMPLEX WITH AN ALPAHIIB BETA3 -SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING | | Descriptor: | Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ... | | Authors: | Zhu, J.H., Zhu, J.Q., Springer, T.A. | | Deposit date: | 2010-06-15 | | Release date: | 2010-12-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
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3NIF | | THE CLOSED HEADPIECE OF INTEGRIN IIB 3 AND ITS COMPLEX WITH AN IIB 3 -SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING | | Descriptor: | Integrin alphaIIB beta3, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ... | | Authors: | Zhu, J.H., Zhu, J.Q., Springer, T.A. | | Deposit date: | 2010-06-15 | | Release date: | 2010-12-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
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3NIG | | THE CLOSED HEADPIECE OF INTEGRIN IIB 3 AND ITS COMPLEX WITH AN IIB 3 -SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING | | Descriptor: | Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ... | | Authors: | Zhu, J.H., Zhu, J.Q., Springer, T.A. | | Deposit date: | 2010-06-15 | | Release date: | 2010-12-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
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3T3M | | A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS | | Descriptor: | Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ... | | Authors: | Zhu, J., Zhu, J., Springer, T.A. | | Deposit date: | 2011-07-25 | | Release date: | 2012-03-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
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3T3P | | A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS | | Descriptor: | Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ... | | Authors: | Zhu, J., Zhu, J., Springer, T.A. | | Deposit date: | 2011-07-25 | | Release date: | 2012-03-28 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
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6MK0 | | INTEGRIN ALPHAVBETA3 ECTODOMAIN BOUND TO ANTAGONIST TDI-4161 | | Descriptor: | Integrin alpha-V, Integrin beta-3, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | van Agthoven, J., Arnaout, M.A. | | Deposit date: | 2018-09-24 | | Release date: | 2019-09-25 | | Last modified: | 2020-02-12 | | Method: | X-RAY DIFFRACTION (3.005 Å) | | Cite: | Novel Pure alphaVbeta3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations
Acs Pharmacol Transl Sci, 2, 2019
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2VC2 | | RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST L-739758 | | Descriptor: | INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ... | | Authors: | Springer, T.A., Zhu, J., Xiao, T. | | Deposit date: | 2007-09-18 | | Release date: | 2008-09-02 | | Last modified: | 2019-11-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
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2VDK | | RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE | | Descriptor: | INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ... | | Authors: | Springer, T.A., Zhu, J., Xiao, T. | | Deposit date: | 2007-10-10 | | Release date: | 2008-09-02 | | Last modified: | 2019-11-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
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2VDL | | RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE | | Descriptor: | INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ... | | Authors: | Springer, T.A., Zhu, J., Xiao, T. | | Deposit date: | 2007-10-10 | | Release date: | 2008-09-02 | | Last modified: | 2019-02-06 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
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2VDM | | RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST TIROFIBAN | | Descriptor: | INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ... | | Authors: | Springer, T.A., Zhu, J., Xiao, T. | | Deposit date: | 2007-10-10 | | Release date: | 2008-09-02 | | Last modified: | 2019-11-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
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2VDN | | RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST EPTIFIBATIDE | | Descriptor: | INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, EPTIFIBATIDE, ... | | Authors: | Springer, T.A., Zhu, J., Xiao, T. | | Deposit date: | 2007-10-10 | | Release date: | 2008-09-02 | | Last modified: | 2019-11-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
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2VDO | | INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQAGDV | | Descriptor: | INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ... | | Authors: | Springer, T.A., Zhu, J., Xiao, T. | | Deposit date: | 2007-10-10 | | Release date: | 2008-09-02 | | Last modified: | 2019-02-06 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
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2VDP | | INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE,LGGAKQAGDV | | Descriptor: | INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ... | | Authors: | Springer, T.A., Zhu, J., Xiao, T. | | Deposit date: | 2007-10-10 | | Release date: | 2008-09-02 | | Last modified: | 2019-02-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
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2VDQ | | INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQRGDV | | Descriptor: | INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ... | | Authors: | Springer, T.A., Zhu, J., Xiao, T. | | Deposit date: | 2007-10-10 | | Release date: | 2008-09-02 | | Last modified: | 2019-11-20 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
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2VDR | | INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, LGGAKQRGDV | | Descriptor: | INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ... | | Authors: | Springer, T.A., Zhu, J., Xiao, T. | | Deposit date: | 2007-10-10 | | Release date: | 2008-09-02 | | Last modified: | 2019-02-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
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