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1TYE
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STRUCTURAL BASIS FOR ALLOSTERY IN INTEGRINS AND BINDING OF LIGAND-MIMETIC THERAPEUTICS TO THE PLATELET RECEPTOR FOR FIBRINOGEN
Descriptor:Integrin alpha-IIb, Integrin beta-3, CALCIUM ION, ...
Authors:Xiao, T., Takagi, J., Coller, B.S., Wang, J.-H., Springer, T.A.
Deposit date:2004-07-07
Release date:2004-10-12
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
Nature, 432, 2004
4CAK
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THREE-DIMENSIONAL RECONSTRUCTION OF INTACT HUMAN INTEGRIN ALPHAIIBBETA3 IN A PHOSPHOLIPID BILAYER NANODISC
Descriptor:Integrin alpha-IIb, Integrin beta-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Choi, W.S., Rice, W.J., Stokes, D.L., Coller, B.S.
Deposit date:2013-10-08
Release date:2013-10-30
Last modified:2019-09-11
Method:ELECTRON MICROSCOPY (20.5 Å)
Cite:Three-Dimensional Reconstruction of Intact Human Integrin Alphaiibbeta3; New Implications for Activation-Dependent Ligand Binding.
Blood, 122, 2013
6V4P
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STRUCTURE OF THE INTEGRIN ALPHAIIBBETA3-ABCIXIMAB COMPLEX
Descriptor:Integrin alpha-IIb, Integrin beta-3, Abciximab, ...
Authors:Nesic, D., Zhang, Y., Spasic, A., Li, J., Provasi, D., Filizola, M., Walz, T., Coller, B.S.
Deposit date:2019-11-28
Release date:2020-02-05
Last modified:2020-03-11
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-Electron Microscopy Structure of the alpha IIb beta 3-Abciximab Complex.
Arterioscler Thromb Vasc Biol., 40, 2020
3NID
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THE CLOSED HEADPIECE OF INTEGRIN ALPHAIIB BETA3 AND ITS COMPLEX WITH AN ALPAHIIB BETA3 -SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING
Descriptor:Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ...
Authors:Zhu, J.H., Zhu, J.Q., Springer, T.A.
Deposit date:2010-06-15
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
3NIF
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THE CLOSED HEADPIECE OF INTEGRIN IIB 3 AND ITS COMPLEX WITH AN IIB 3 -SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING
Descriptor:Integrin alphaIIB beta3, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ...
Authors:Zhu, J.H., Zhu, J.Q., Springer, T.A.
Deposit date:2010-06-15
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
3NIG
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THE CLOSED HEADPIECE OF INTEGRIN IIB 3 AND ITS COMPLEX WITH AN IIB 3 -SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING
Descriptor:Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ...
Authors:Zhu, J.H., Zhu, J.Q., Springer, T.A.
Deposit date:2010-06-15
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
3T3M
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A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS
Descriptor:Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ...
Authors:Zhu, J., Zhu, J., Springer, T.A.
Deposit date:2011-07-25
Release date:2012-03-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
3T3P
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A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS
Descriptor:Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ...
Authors:Zhu, J., Zhu, J., Springer, T.A.
Deposit date:2011-07-25
Release date:2012-03-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
6MK0
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INTEGRIN ALPHAVBETA3 ECTODOMAIN BOUND TO ANTAGONIST TDI-4161
Descriptor:Integrin alpha-V, Integrin beta-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:van Agthoven, J., Arnaout, M.A.
Deposit date:2018-09-24
Release date:2019-09-25
Last modified:2020-02-12
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Novel Pure alphaVbeta3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations
Acs Pharmacol Transl Sci, 2, 2019
2VC2
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST L-739758
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-09-18
Release date:2008-09-02
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDK
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDL
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDM
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST TIROFIBAN
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDN
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST EPTIFIBATIDE
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, EPTIFIBATIDE, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDO
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQAGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDP
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE,LGGAKQAGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDQ
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQRGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDR
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, LGGAKQRGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008