Author results

2NMX
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STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE I
Descriptor:Carbonic anhydrase 1, ZINC ION, N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE, ...
Authors:Christianson, D.W., Jude, K.M.
Deposit date:2006-10-23
Release date:2007-04-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II
J.Am.Chem.Soc., 129, 2007
2NN1
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STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE I
Descriptor:Carbonic anhydrase 1, ZINC ION, 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID, ...
Authors:Christianson, D.W., Jude, K.M.
Deposit date:2006-10-23
Release date:2007-04-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II
J.Am.Chem.Soc., 129, 2007
2NN7
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STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE I
Descriptor:Carbonic anhydrase 1, ZINC ION, ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE, ...
Authors:Christianson, D.W., Jude, K.M.
Deposit date:2006-10-23
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II.
J.Am.Chem.Soc., 129, 2007
2NNG
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STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase 2, ZINC ION, 4-(2-AMINOETHYL)BENZENESULFONAMIDE, ...
Authors:Christianson, D.W., Jude, K.M.
Deposit date:2006-10-24
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II.
J.Am.Chem.Soc., 129, 2007
2NNO
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STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase 2, ZINC ION, 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID, ...
Authors:Christianson, D.W., Jude, K.M.
Deposit date:2006-10-24
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.01 Å)
Cite:Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II.
J.Am.Chem.Soc., 129, 2007
2NNS
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STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase 2, ZINC ION, CHLORIDE ION, ...
Authors:Christianson, D.W., Jude, K.M.
Deposit date:2006-10-24
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II.
J.Am.Chem.Soc., 129, 2007
2NNV
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STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase 2, ZINC ION, ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE, ...
Authors:Christianson, D.W., Jude, K.M.
Deposit date:2006-10-24
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II.
J.Am.Chem.Soc., 129, 2007
5D1B
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CRYSTAL STRUCTURE OF G117E HDAC8 IN COMPLEX WITH TSA
Descriptor:Histone deacetylase 8, ZINC ION, POTASSIUM ION, ...
Authors:Decroos, C., Christianson, N.H., Gullett, L.E., Bowman, C.M., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2015-08-04
Release date:2015-10-21
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
5D1C
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CRYSTAL STRUCTURE OF D233G-Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8, HDAC8 Fluor de Lys tetrapeptide substrate, POTASSIUM ION, ...
Authors:Decroos, C., Christianson, N.H., Gullett, L.E., Bowman, C.M., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2015-08-04
Release date:2015-10-21
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.422 Å)
Cite:Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
5D1D
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CRYSTAL STRUCTURE OF P91L-Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8, HDAC8 Fluor de Lys tetrapeptide substrate, ZINC ION, ...
Authors:Decroos, C., Christianson, N.H., Gullett, L.E., Bowman, C.M., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2015-08-04
Release date:2015-10-21
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.011 Å)
Cite:Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
2AEB
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CRYSTAL STRUCTURE OF HUMAN ARGINASE I AT 1.29 A RESOLUTION AND EXPLORATION OF INHIBITION IN IMMUNE RESPONSE.
Descriptor:Arginase 1, MANGANESE (II) ION, 2(S)-AMINO-6-BORONOHEXANOIC ACID
Authors:Di Costanzo, L., Sabio, G., Mora, A., Rodriguez, P.C., Ochoa, A.C., Centeno, F., Christianson, D.W.
Deposit date:2005-07-21
Release date:2005-09-06
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in the immune response.
Proc.Natl.Acad.Sci.Usa, 102, 2005
4QA0
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CRYSTAL STRUCTURE OF C153F HDAC8 IN COMPLEX WITH SAHA
Descriptor:Histone deacetylase 8, ZINC ION, POTASSIUM ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.242 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA1
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CRYSTAL STRUCTURE OF A188T HDAC8 IN COMPLEX WITH M344
Descriptor:Histone deacetylase 8, POTASSIUM ION, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA2
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CRYSTAL STRUCTURE OF I243N HDAC8 IN COMPLEX WITH SAHA
Descriptor:Histone deacetylase 8, POTASSIUM ION, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.377 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA3
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CRYSTAL STRUCTURE OF T311M HDAC8 IN COMPLEX WITH TRICHOSTATIN A (TSA)
Descriptor:Histone deacetylase 8, TRICHOSTATIN A, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.876 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA4
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CRYSTAL STRUCTURE OF H334R HDAC8 IN COMPLEX WITH M344
Descriptor:Histone deacetylase 8, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA5
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CRYSTAL STRUCTURE OF A188T/Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8, tetrapeptide substrate, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA6
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CRYSTAL STRUCTURE OF I243N/Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8, tetrapeptide substrate, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.053 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA7
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CRYSTAL STRUCTURE OF H334R/Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8, tetrapeptide substrate, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
1HQ5
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CRYSTAL STRUCTURE OF THE BINUCLEAR MANGANESE METALLOENZYME ARGINASE COMPLEXED WITH S-(2-BORONOETHYL)-L-CYSTEINE, AN L-ARGININE ANALOGUE
Descriptor:ARGINASE 1, MANGANESE (II) ION, S-2-(BORONOETHYL)-L-CYSTEINE
Authors:Kim, N.N., Cox, J.D., Baggio, R.F., Emig, F.A., Mistry, S.K., Harper, S.L., Speicher, D.W., Morris Jr., S.M., Ash, D.E., Traish, A., Christianson, D.W.
Deposit date:2000-12-14
Release date:2001-04-04
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum.
Biochemistry, 40, 2001
1A42
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HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE
Descriptor:CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION, ...
Authors:Boriack-Sjodin, P.A., Christianson, D.W.
Deposit date:1998-02-10
Release date:1999-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.
Protein Sci., 7, 1998
1AS4
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CLEAVED ANTICHYMOTRYPSIN A349R
Descriptor:ANTICHYMOTRYPSIN, ACETATE ION
Authors:Lukacs, C.M., Christianson, D.W.
Deposit date:1997-08-12
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction.
Biochemistry, 37, 1998
1EK1
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CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CIU INHIBITOR
Descriptor:EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-(4-IODOPHENYL)UREA
Authors:Argiriadi, M.A., Morisseau, C., Goodrow, M.H., Dowdy, D.L., Hammock, B.D., Christianson, D.W.
Deposit date:2000-03-06
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation.
J.Biol.Chem., 275, 2000
1EK2
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CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CDU INHIBITOR
Descriptor:EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-DECYLUREA
Authors:Argiriadi, M.A., Morisseau, C., Goodrow, M.H., Dowdy, D.L., Hammock, B.D., Christianson, D.W.
Deposit date:2000-03-06
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation.
J.Biol.Chem., 275, 2000
1KEQ
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CRYSTAL STRUCTURE OF F65A/Y131C CARBONIC ANHYDRASE V, COVALENTLY MODIFIED WITH 4-CHLOROMETHYLIMIDAZOLE
Descriptor:F65A/Y131C-MI Carbonic Anhydrase V, POTASSIUM ION, ZINC ION, ...
Authors:Jude, K.M., Wright, S.K., Tu, C., Silverman, D.N., Viola, R.E., Christianson, D.W.
Deposit date:2001-11-16
Release date:2002-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle.
Biochemistry, 41, 2002