2NMX | | STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE I | | Descriptor: | Carbonic anhydrase 1, ZINC ION, N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE, ... | | Authors: | Christianson, D.W., Jude, K.M. | | Deposit date: | 2006-10-23 | | Release date: | 2007-04-24 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II
J.Am.Chem.Soc., 129, 2007
|
|
2NN1 | | STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE I | | Descriptor: | Carbonic anhydrase 1, ZINC ION, 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID, ... | | Authors: | Christianson, D.W., Jude, K.M. | | Deposit date: | 2006-10-23 | | Release date: | 2007-04-24 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II
J.Am.Chem.Soc., 129, 2007
|
|
2NN7 | | STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE I | | Descriptor: | Carbonic anhydrase 1, ZINC ION, ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE, ... | | Authors: | Christianson, D.W., Jude, K.M. | | Deposit date: | 2006-10-23 | | Release date: | 2007-05-08 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II.
J.Am.Chem.Soc., 129, 2007
|
|
2NNG | | STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE II | | Descriptor: | Carbonic anhydrase 2, ZINC ION, 4-(2-AMINOETHYL)BENZENESULFONAMIDE, ... | | Authors: | Christianson, D.W., Jude, K.M. | | Deposit date: | 2006-10-24 | | Release date: | 2007-05-08 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II.
J.Am.Chem.Soc., 129, 2007
|
|
2NNO | | STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE II | | Descriptor: | Carbonic anhydrase 2, ZINC ION, 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID, ... | | Authors: | Christianson, D.W., Jude, K.M. | | Deposit date: | 2006-10-24 | | Release date: | 2007-05-08 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.01 Å) | | Cite: | Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II.
J.Am.Chem.Soc., 129, 2007
|
|
2NNS | |
2NNV | | STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE II | | Descriptor: | Carbonic anhydrase 2, ZINC ION, ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE, ... | | Authors: | Christianson, D.W., Jude, K.M. | | Deposit date: | 2006-10-24 | | Release date: | 2007-05-08 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II.
J.Am.Chem.Soc., 129, 2007
|
|
5D1B | | CRYSTAL STRUCTURE OF G117E HDAC8 IN COMPLEX WITH TSA | | Descriptor: | Histone deacetylase 8, ZINC ION, POTASSIUM ION, ... | | Authors: | Decroos, C., Christianson, N.H., Gullett, L.E., Bowman, C.M., Christianson, K.E., Deardorff, M.A., Christianson, D.W. | | Deposit date: | 2015-08-04 | | Release date: | 2015-10-21 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
|
|
5D1C | | CRYSTAL STRUCTURE OF D233G-Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE | | Descriptor: | Histone deacetylase 8, HDAC8 Fluor de Lys tetrapeptide substrate, POTASSIUM ION, ... | | Authors: | Decroos, C., Christianson, N.H., Gullett, L.E., Bowman, C.M., Christianson, K.E., Deardorff, M.A., Christianson, D.W. | | Deposit date: | 2015-08-04 | | Release date: | 2015-10-21 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (1.422 Å) | | Cite: | Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
|
|
5D1D | | CRYSTAL STRUCTURE OF P91L-Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE | | Descriptor: | Histone deacetylase 8, HDAC8 Fluor de Lys tetrapeptide substrate, ZINC ION, ... | | Authors: | Decroos, C., Christianson, N.H., Gullett, L.E., Bowman, C.M., Christianson, K.E., Deardorff, M.A., Christianson, D.W. | | Deposit date: | 2015-08-04 | | Release date: | 2015-10-21 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (2.011 Å) | | Cite: | Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
|
|
2AEB | | CRYSTAL STRUCTURE OF HUMAN ARGINASE I AT 1.29 A RESOLUTION AND EXPLORATION OF INHIBITION IN IMMUNE RESPONSE. | | Descriptor: | Arginase 1, MANGANESE (II) ION, 2(S)-AMINO-6-BORONOHEXANOIC ACID | | Authors: | Di Costanzo, L., Sabio, G., Mora, A., Rodriguez, P.C., Ochoa, A.C., Centeno, F., Christianson, D.W. | | Deposit date: | 2005-07-21 | | Release date: | 2005-09-06 | | Last modified: | 2018-03-07 | | Method: | X-RAY DIFFRACTION (1.29 Å) | | Cite: | Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in the immune response.
Proc.Natl.Acad.Sci.Usa, 102, 2005
|
|
4QA0 | | CRYSTAL STRUCTURE OF C153F HDAC8 IN COMPLEX WITH SAHA | | Descriptor: | Histone deacetylase 8, ZINC ION, POTASSIUM ION, ... | | Authors: | Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W. | | Deposit date: | 2014-05-02 | | Release date: | 2014-08-06 | | Last modified: | 2014-10-01 | | Method: | X-RAY DIFFRACTION (2.242 Å) | | Cite: | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
|
|
4QA1 | | CRYSTAL STRUCTURE OF A188T HDAC8 IN COMPLEX WITH M344 | | Descriptor: | Histone deacetylase 8, POTASSIUM ION, ZINC ION, ... | | Authors: | Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W. | | Deposit date: | 2014-05-02 | | Release date: | 2014-08-06 | | Last modified: | 2014-10-01 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
|
|
4QA2 | | CRYSTAL STRUCTURE OF I243N HDAC8 IN COMPLEX WITH SAHA | | Descriptor: | Histone deacetylase 8, POTASSIUM ION, ZINC ION, ... | | Authors: | Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W. | | Deposit date: | 2014-05-02 | | Release date: | 2014-08-06 | | Last modified: | 2014-10-01 | | Method: | X-RAY DIFFRACTION (2.377 Å) | | Cite: | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
|
|
4QA3 | | CRYSTAL STRUCTURE OF T311M HDAC8 IN COMPLEX WITH TRICHOSTATIN A (TSA) | | Descriptor: | Histone deacetylase 8, TRICHOSTATIN A, ZINC ION, ... | | Authors: | Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W. | | Deposit date: | 2014-05-02 | | Release date: | 2014-08-06 | | Last modified: | 2014-10-01 | | Method: | X-RAY DIFFRACTION (2.876 Å) | | Cite: | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
|
|
4QA4 | | CRYSTAL STRUCTURE OF H334R HDAC8 IN COMPLEX WITH M344 | | Descriptor: | Histone deacetylase 8, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, ZINC ION, ... | | Authors: | Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W. | | Deposit date: | 2014-05-02 | | Release date: | 2014-08-06 | | Last modified: | 2014-10-01 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
|
|
4QA5 | | CRYSTAL STRUCTURE OF A188T/Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE | | Descriptor: | Histone deacetylase 8, tetrapeptide substrate, ZINC ION, ... | | Authors: | Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W. | | Deposit date: | 2014-05-02 | | Release date: | 2014-08-06 | | Last modified: | 2014-10-01 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
|
|
4QA6 | | CRYSTAL STRUCTURE OF I243N/Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE | | Descriptor: | Histone deacetylase 8, tetrapeptide substrate, ZINC ION, ... | | Authors: | Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W. | | Deposit date: | 2014-05-02 | | Release date: | 2014-08-06 | | Last modified: | 2014-10-01 | | Method: | X-RAY DIFFRACTION (2.053 Å) | | Cite: | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
|
|
4QA7 | | CRYSTAL STRUCTURE OF H334R/Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE | | Descriptor: | Histone deacetylase 8, tetrapeptide substrate, ZINC ION, ... | | Authors: | Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W. | | Deposit date: | 2014-05-02 | | Release date: | 2014-08-06 | | Last modified: | 2014-10-01 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
|
|
1HQ5 | | CRYSTAL STRUCTURE OF THE BINUCLEAR MANGANESE METALLOENZYME ARGINASE COMPLEXED WITH S-(2-BORONOETHYL)-L-CYSTEINE, AN L-ARGININE ANALOGUE | | Descriptor: | ARGINASE 1, MANGANESE (II) ION, S-2-(BORONOETHYL)-L-CYSTEINE | | Authors: | Kim, N.N., Cox, J.D., Baggio, R.F., Emig, F.A., Mistry, S.K., Harper, S.L., Speicher, D.W., Morris Jr., S.M., Ash, D.E., Traish, A., Christianson, D.W. | | Deposit date: | 2000-12-14 | | Release date: | 2001-04-04 | | Last modified: | 2018-04-04 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum.
Biochemistry, 40, 2001
|
|
1A42 | |
1AS4 | | CLEAVED ANTICHYMOTRYPSIN A349R | | Descriptor: | ANTICHYMOTRYPSIN, ACETATE ION | | Authors: | Lukacs, C.M., Christianson, D.W. | | Deposit date: | 1997-08-12 | | Release date: | 1998-02-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction.
Biochemistry, 37, 1998
|
|
1EK1 | | CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CIU INHIBITOR | | Descriptor: | EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-(4-IODOPHENYL)UREA | | Authors: | Argiriadi, M.A., Morisseau, C., Goodrow, M.H., Dowdy, D.L., Hammock, B.D., Christianson, D.W. | | Deposit date: | 2000-03-06 | | Release date: | 2000-05-31 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation.
J.Biol.Chem., 275, 2000
|
|
1EK2 | | CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CDU INHIBITOR | | Descriptor: | EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-DECYLUREA | | Authors: | Argiriadi, M.A., Morisseau, C., Goodrow, M.H., Dowdy, D.L., Hammock, B.D., Christianson, D.W. | | Deposit date: | 2000-03-06 | | Release date: | 2000-05-31 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation.
J.Biol.Chem., 275, 2000
|
|
1KEQ | | CRYSTAL STRUCTURE OF F65A/Y131C CARBONIC ANHYDRASE V, COVALENTLY MODIFIED WITH 4-CHLOROMETHYLIMIDAZOLE | | Descriptor: | F65A/Y131C-MI Carbonic Anhydrase V, POTASSIUM ION, ZINC ION, ... | | Authors: | Jude, K.M., Wright, S.K., Tu, C., Silverman, D.N., Viola, R.E., Christianson, D.W. | | Deposit date: | 2001-11-16 | | Release date: | 2002-03-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle.
Biochemistry, 41, 2002
|
|
