Author results

1NHU
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HEPATITIS C VIRUS RNA POLYMERASE IN COMPLEX WITH NON-NUCLEOSIDE ANALOGUE INHIBITOR
Descriptor:HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE, (2S)-2-[(2,4-DICHLORO-BENZOYL)-(3-TRIFLUOROMETHYL-BENZYL)-AMINO]-3-PHENYL-PROPIONIC ACID
Authors:Wang, M., Ng, K.K.S., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bedard, J., Morin, N., Nguyen-Ba, N., Alaoui-Ismaili, M.H., Bethell, R.C., James, M.N.G.
Deposit date:2002-12-19
Release date:2003-03-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-Nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase: Crystal Structures and Mechanism of Inhibition
J.Biol.Chem., 278, 2003
1NHV
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HEPATITIS C VIRUS RNA POLYMERASE IN COMPLEX WITH NON-NUCLEOSIDE ANALOGUE INHIBITOR
Descriptor:HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE, (2S)-2-[(5-BENZOFURAN-2-YL-THIOPHEN-2-YLMETHYL)-(2,4-DICHLORO-BENZOYL)-AMINO]-3-PHENYL-PROPIONIC ACID
Authors:Wang, M., Ng, K.K.S., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bedard, J., Morin, N., Nguyen-Ba, N., Alaoui-Ismaili, M.H., Bethell, R.C., James, M.N.G.
Deposit date:2002-12-19
Release date:2003-03-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Non-Nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase: Crystal Structures and Mechanism of Inhibition
J.Biol.Chem., 278, 2003
1YUY
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HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE GENOTYPE 2A
Descriptor:RNA-Dependent RNA polymerase, SULFATE ION
Authors:Biswal, B.K., Cherney, M.M., Wang, M., Chan, L., Yannopoulos, C.G., Bilimoria, D., Nicolas, O., Bedard, J., James, M.N.G.
Deposit date:2005-02-14
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
1YV2
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HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE GENOTYPE 2A
Descriptor:RNA dependent RNA polymerase, SULFATE ION, GLYCEROL
Authors:Biswal, B.K., Cherney, M.M., Wang, M., Chan, L., Yannopoulos, C.G., Bilimoria, D., Nicolas, O., Bedard, J., James, M.N.G.
Deposit date:2005-02-14
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors
J.Biol.Chem., 280, 2005
1YVX
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HEPATITIS C VIRUS RNA POLYMERASE GENOTYPE 2A IN COMPLEX WITH NON- NUCLEOSIDE ANALOGUE INHIBITOR
Descriptor:RNA dependent RNA polymerase, SULFATE ION, 3-[ISOPROPYL(4-METHYLBENZOYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID
Authors:Biswal, B.K., Cherney, M.M., Wang, M., Chan, L., Yannopoulos, C.G., Bilimoria, D., Nicolas, O., Bedard, J., James, M.N.G.
Deposit date:2005-02-16
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
1YVZ
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HEPATITIS C VIRUS RNA POLYMERASE GENOTYPE 2A IN COMPLEX WITH NON- NUCLEOSIDE ANALOGUE INHIBITOR
Descriptor:RNA dependent RNA polymerase, SULFATE ION, 3-[(2,4-DICHLOROBENZOYL)(ISOPROPYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID
Authors:Biswal, B.K., Cherney, M.M., Wang, M., Chan, L., Yannopoulos, C.G., Bilimoria, D., Nicolas, O., Bedard, J., James, M.N.G.
Deposit date:2005-02-16
Release date:2005-03-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
2D3U
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X-RAY CRYSTAL STRUCTURE OF HEPATITIS C VIRUS RNA DEPENDENT RNA POLYMERASE IN COMPLEX WITH NON-NUCLEOSIDE ANALOGUE INHIBITOR
Descriptor:polyprotein, 5-(4-CYANOPHENYL)-3-{[(2-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID
Authors:Biswal, B.K., Wang, M., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bilimoria, D., Bedard, J., James, M.N.G.
Deposit date:2005-10-02
Release date:2006-08-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition
J.Mol.Biol., 361, 2006
2D3Z
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X-RAY CRYSTAL STRUCTURE OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH NON-NUCLEOSIDE ANALOGUE INHIBITOR
Descriptor:polyprotein, 5-(4-FLUOROPHENYL)-3-{[(4-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID
Authors:Biswal, B.K., Wang, M., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bilimoria, D., Bedard, J., James, M.N.G.
Deposit date:2005-10-04
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition
J.Mol.Biol., 361, 2006
2D41
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X-RAY CRYSTAL STRUCTURE OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR
Descriptor:polyprotein, 5'-ACETYL-4-{[(2,4-DIMETHYLPHENYL)SULFONYL]AMINO}-2,2'-BITHIOPHENE-5-CARBOXYLIC ACID
Authors:Biswal, B.K., Wang, M., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bilimoria, D., Bedard, J., James, M.N.G.
Deposit date:2005-10-05
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition
J.Mol.Biol., 361, 2006
2K1Z
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SOLUTION STRUCTURE OF PAR-3 PDZ3
Descriptor:Partitioning-defective 3 homolog
Authors:Feng, W., Wu, H., Chan, L., Zhang, M.
Deposit date:2008-03-18
Release date:2008-06-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of Par-3 PDZ3
To be Published
2K20
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SOLUTION STRUCTURE OF PAR-3 PDZ3 IN COMPLEX WITH PTEN PEPTIDE
Descriptor:Partitioning-defective 3 homolog, Protein tyrosine phosphatase and tensin homolog
Authors:Feng, W., Wu, H., Chan, L., Zhang, M.
Deposit date:2008-03-18
Release date:2008-06-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of Par-3 PDZ3 in complex with PTEN peptide
To be Published
2KNP
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ISOLATION AND CHARACTERIZATION OF PEPTIDES FROM MOMORDICA COCHINCHINENSIS SEEDS.
Descriptor:MCoCC-1
Authors:Daly, N.L., Chan, L.
Deposit date:2009-08-30
Release date:2009-11-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Isolation and characterization of peptides from Momordica cochinchinensis seeds.
J.Nat.Prod., 72, 2009
2M2Q
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SOLUTION STRUCTURE OF MCH-1: A NOVEL INHIBITOR CYSTINE KNOT PEPTIDE FROM MOMORDICA CHARANTIA
Descriptor:Inhibitor cystine knot peptide MCh-1
Authors:He, W., Chan, L., Clark, R.J., Tang, J., Zeng, G., Franco, O.L., Cantacessi, C., Craik, D.J., Daly, N.L., Tan, N.
Deposit date:2013-01-01
Release date:2013-11-06
Method:SOLUTION NMR
Cite:Novel Inhibitor Cystine Knot Peptides from Momordica charantia.
Plos One, 8, 2013
2M2R
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SOLUTION STRUCTURE OF MCH-2: A NOVEL INHIBITOR CYSTINE KNOT PEPTIDE FROM MOMORDICA CHARANTIA
Descriptor:Inhibitor cystine knot peptide MCh-2
Authors:He, W., Chan, L., Clark, R.J., Tang, J., Zeng, G., Franco, O.L., Cantacessi, C., Craik, D.J., Daly, N.L., Tan, N.
Deposit date:2013-01-01
Release date:2013-11-06
Method:SOLUTION NMR
Cite:Novel Inhibitor Cystine Knot Peptides from Momordica charantia.
Plos One, 8, 2013
2ZKU
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STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE IN A NEW CRYSTAL FORM
Descriptor:Genome polyprotein, ACETIC ACID, GLYCEROL
Authors:Biswal, B.K.
Deposit date:2008-03-31
Release date:2009-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of Hepatitis C Virus Ns5B Polymerase in a New Crystal Form: Insights Into Oligomerisation and Allosteric Nucleotide Binding Site
To be Published
4PZW
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SYNTHESIS, CHARACTERIZATION AND PK/PD STUDIES OF A SERIES OF SPIROCYCLIC PYRANOCHROMENE BACE1 INHIBITORS
Descriptor:Beta-secretase 1, NICKEL (II) ION, (4R,4a'S,10a'S)-7'-(5-chloropyridin-3-yl)-3',4',4a',10a'-tetrahydro-1'H-spiro[1,3-oxazole-4,5'-pyrano[3,4-b]chromen]-2-amine
Authors:Vigers, G.P.A.
Deposit date:2014-03-31
Release date:2014-05-14
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
4PZX
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SYNTHESIS, CHARACTERIZATION AND PK/PD STUDIES OF A SERIES OF SPIROCYCLIC PYRANOCHROMENE BACE1 INHIBITORS
Descriptor:Beta-secretase 1, NICKEL (II) ION, (4R,4a'R,10a'R)-7'-(5-chloropyridin-3-yl)-3',4',4a',10a'-tetrahydro-1'H-spiro[1,3-oxazole-4,5'-pyrano[3,4-b]chromen]-2-amine
Authors:Vigers, G.P.A.
Deposit date:2014-03-31
Release date:2014-05-14
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
2HX7
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CRYSTAL STRUCTURE OF CU(II) AZURIN WITH THE METAL-BINDING LOOP SEQUENCE "CTFPGHSALM" REPLACED WITH "CSPHQGAGM"
Descriptor:Azurin, COPPER (II) ION
Authors:Banfield, M.J.
Deposit date:2006-08-03
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Engineering Copper Sites in Proteins: Loops Confer Native Structures and Properties to Chimeric Cupredoxins.
J.Am.Chem.Soc., 129, 2007
2HX8
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CRYSTAL STRUCTURE OF CU(I) AZURIN WITH THE METAL-BINDING LOOP SEQUENCE "CTFPGHSALM" REPLACED WITH "CSPHQGAGM", AT PH5
Descriptor:Azurin, COPPER (I) ION
Authors:Banfield, M.J.
Deposit date:2006-08-03
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Engineering Copper Sites in Proteins: Loops Confer Native Structures and Properties to Chimeric Cupredoxins.
J.Am.Chem.Soc., 129, 2007
2HX9
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CRYSTAL STRUCTURE OF CU(I) AZURIN WITH THE METAL-BINDING LOOP SEQUENCE "CTFPGHSALM" REPLACED WITH "CSPHQGAGM", AT PH4
Descriptor:Azurin, COPPER (I) ION
Authors:Banfield, M.J.
Deposit date:2006-08-03
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Engineering Copper Sites in Proteins: Loops Confer Native Structures and Properties to Chimeric Cupredoxins.
J.Am.Chem.Soc., 129, 2007
2HXA
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CRYSTAL STRUCTURE OF CU(I) AZURIN WITH THE METAL-BINDING LOOP SEQUENCE "CTFPGHSALM" REPLACED WITH "CSPHQGAGM", AT PH3.5
Descriptor:Azurin, COPPER (I) ION
Authors:Banfield, M.J.
Deposit date:2006-08-03
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Engineering Copper Sites in Proteins: Loops Confer Native Structures and Properties to Chimeric Cupredoxins.
J.Am.Chem.Soc., 129, 2007