6VYJ

Human UHRF1 TTD domain in complex with a fragment

Summary for 6VYJ

Entry DOI	10.2210/pdb6vyj/pdb
Descriptor	E3 ubiquitin-protein ligase UHRF1, 2,4-dimethylpyridine, beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	ligase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	19606.76
Authors	Campbell, J.C.,Chang, L.,Young, D.W. (deposition date: 2020-02-26, release date: 2021-01-27, Last modification date: 2023-10-11)
Primary citation	Chang, L.,Campbell, J.,Raji, I.O.,Guduru, S.K.R.,Kandel, P.,Nguyen, M.,Liu, S.,Tran, K.,Venugopal, N.K.,Taylor, B.C.,Holt, M.V.,Young, N.L.,Samuel, E.L.G.,Jain, P.,Santini, C.,Sankaran, B.,MacKenzie, K.R.,Young, D.W. Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery. Sci Rep, 11:1121-1121, 2021 Cited by PubMed: 33441849 DOI: 10.1038/s41598-020-80588-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.39 Å)

Structure validation