Author results

6CQA
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E. COLI DHFR COMPLEX WITH INHIBITOR AMPQD
分子名称:Dihydrofolate reductase, SULFATE ION, 7-[(3-aminophenyl)methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine
著者Cao, H., Rodrigues, J., Benach, J., Wasserman, S., Morisco, L., Koss, J., Shakhnovich, E., Skolnick, J.
登録日2018-03-14
公開日2019-01-09
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release.
Commun Biol, 1, 2018
6CW7
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E. COLI DHFR PRODUCT COMPLEX WITH (6S)-5,6,7,8-TETRAHYDROFOLATE
分子名称:Dihydrofolate reductase, (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, ...
著者Cao, H., Rodrigues, J., Benach, J., Frommelt, A., Morisco, L., Koss, J., Shakhnovich, E., Skolnick, J.
登録日2018-03-30
公開日2019-01-09
実験手法X-RAY DIFFRACTION (1.03 Å)
主引用文献The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release.
Commun Biol, 1, 2018
6CXK
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E. COLI DHFR SUBSTRATE COMPLEX WITH DIHYDROFOLATE
分子名称:Dihydrofolate reductase, MAGNESIUM ION, CHLORIDE ION, ...
著者Cao, H., Rodrigues, J., Benach, J., Frommelt, A., Morisco, L., Koss, J., Shakhnovich, E., Skolnick, J.
登録日2018-04-03
公開日2019-01-09
実験手法X-RAY DIFFRACTION (1.108 Å)
主引用文献The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release.
Commun Biol, 1, 2018
6CYV
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E. COLI DHFR TERNARY COMPLEX WITH NADP AND DIHYDROFOLATE
分子名称:Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, DIHYDROFOLIC ACID
著者Cao, H., Rodrigues, J., Benach, J., Frommelt, A., Morisco, L., Koss, J., Shakhnovich, E., Skolnick, J.
登録日2018-04-06
公開日2019-01-09
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release.
Commun Biol, 1, 2018
3NRZ
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CRYSTAL STRUCTURE OF BOVINE XANTHINE OXIDASE IN COMPLEX WITH HYPOXANTHINE
分子名称:Xanthine dehydrogenase/oxidase, FE2/S2 (INORGANIC) CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Cao, H., Pauff, J.M., Hille, R.
登録日2010-07-01
公開日2010-07-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid.
J.Biol.Chem., 285, 2010
3NS1
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CRYSTAL STRUCTURE OF BOVINE XANTHINE OXIDASE IN COMPLEX WITH 6-MERCAPTOPURINE
分子名称:Xanthine dehydrogenase/oxidase, FE2/S2 (INORGANIC) CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Cao, H., Pauff, J.M., Hille, R.
登録日2010-07-01
公開日2010-07-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid.
J.Biol.Chem., 285, 2010
3NVV
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CRYSTAL STRUCTURE OF BOVINE XANTHINE OXIDASE IN COMPLEX WITH ARSENITE
分子名称:Xanthine dehydrogenase/oxidase, FE2/S2 (INORGANIC) CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Cao, H., Hille, R.
登録日2010-07-08
公開日2011-01-19
最終更新日2012-05-09
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献X-ray Crystal Structure of Arsenite-Inhibited Xanthine Oxidase: Mu-Sulfido,Mu-Oxo Double Bridge between Molybdenum and Arsenic in the Active Site.
J.Am.Chem.Soc., 133, 2011
3NVW
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CRYSTAL STRUCTURE OF BOVINE XANTHINE OXIDASE IN COMPLEX WITH GUANINE
分子名称:Xanthine dehydrogenase/oxidase, FE2/S2 (INORGANIC) CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Cao, H., Hille, R.
登録日2010-07-08
公開日2011-01-19
最終更新日2014-09-03
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Substrate orientation and specificity in xanthine oxidase: crystal structures of the enzyme in complex with indole-3-acetaldehyde and guanine.
Biochemistry, 53, 2014
3NVY
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CRYSTAL STRUCTURE OF BOVINE XANTHINE OXIDASE IN COMPLEX WITH QUERCETIN
分子名称:Xanthine dehydrogenase/oxidase, FE2/S2 (INORGANIC) CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Cao, H., Hille, R.
登録日2010-07-08
公開日2011-01-19
最終更新日2014-09-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray Crystal Structure of a Xanthine Oxidase Complex with the Flavonoid Inhibitor Quercetin.
J Nat Prod, 77, 2014
3NVZ
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CRYSTAL STRUCTURE OF BOVINE XANTHINE OXIDASE IN COMPLEX WITH INDOLE-3-ALDEHYDE
分子名称:Xanthine dehydrogenase/oxidase, FE2/S2 (INORGANIC) CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Cao, H., Hille, R.
登録日2010-07-08
公開日2011-01-19
最終更新日2014-09-03
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Substrate orientation and specificity in xanthine oxidase: crystal structures of the enzyme in complex with indole-3-acetaldehyde and guanine.
Biochemistry, 53, 2014
3SR6
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CRYSTAL STRUCTURE OF REDUCED BOVINE XANTHINE OXIDASE IN COMPLEX WITH ARSENITE
分子名称:Xanthine dehydrogenase/oxidase, FE2/S2 (INORGANIC) CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Cao, H., Hille, R.
登録日2011-07-07
公開日2011-07-27
最終更新日2012-05-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献X-ray Crystal Structure of Arsenite-Inhibited Xanthine Oxidase: Mu-Sulfido,Mu-Oxo Double Bridge between Molybdenum and Arsenic in the Active Site.
J.Am.Chem.Soc., 133, 2011
4NI3
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CRYSTAL STRUCTURE OF GH29 FAMILY ALPHA-L-FUCOSIDASE FROM FUSARIUM GRAMINEARUM IN THE CLOSED FORM
分子名称:Alpha-fucosidase GH29, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Cao, H., Walton, J.D., Brumm, P., Phillips Jr., G.N.
登録日2013-11-05
公開日2013-12-25
最終更新日2014-10-01
実験手法X-RAY DIFFRACTION (1.3993 Å)
主引用文献Structure and Substrate Specificity of a Eukaryotic Fucosidase from Fusarium graminearum.
J.Biol.Chem., 289, 2014
4PSP
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CRYSTAL STRUCTURE OF GH29 FAMILY ALPHA-L-FUCOSIDASE FROM FUSARIUM GRAMINEARUM IN THE OPEN FORM
分子名称:Alpha-fucosidase GH29, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Cao, H., Walton, J., Brumm, P., Phillips Jr., G.N.
登録日2014-03-07
公開日2014-03-19
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.561 Å)
主引用文献Structure and Substrate Specificity of a Eukaryotic Fucosidase from Fusarium graminearum.
J.Biol.Chem., 289, 2014
4PSR
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CRYSTAL STRUCTURE OF ALPHA-L-FUCOSIDASE FROM FUSARIUM GRAMINEARUM IN THE OPEN FORM IN COMPLEX WITH L-FUCOSE
分子名称:Alpha-fucosidase GH29, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Cao, H., Walton, J., Brumm, P., Phillips Jr., G.N.
登録日2014-03-07
公開日2014-03-19
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Structure and Substrate Specificity of a Eukaryotic Fucosidase from Fusarium graminearum.
J.Biol.Chem., 289, 2014
6A6O
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CRYSTAL STRUCTURE OF ACETYL ESTER-XYLOSIDE BIFUNCTIONAL HYDROLASE FROM CALDICELLULOSIRUPTOR LACTOACETICUS
分子名称:Esterase/lipase-like protein
著者Cao, H., Huang, Y., Sun, L.C., Liu, X., Liu, T.F., Wang, F.Z., Xin, F.J.
登録日2018-06-28
公開日2019-06-12
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Insights into the Dual-Substrate Recognition and Catalytic Mechanisms of a Bifunctional Acetyl Ester-Xyloside Hydrolase from Caldicellulosiruptor lactoaceticus.
Acs Catalysis, 9, 2019
6DRU
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XYLOSIDASE FROM ASPERGILLUS NIGER
分子名称:Glycosyl hydrolases family 31 family protein, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Cao, H., Xu, W., Betancourt, M., Walton, J.D., Brumm, P., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2018-06-13
公開日2018-08-22
最終更新日2018-08-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of an alpha-xylosidase from Aspergillus niger in complex with xyloglucan fragment
To Be Published
6MR9
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E. COLI DHFR COMPLEX WITH A REACTION INTERMEDIATE
分子名称:Dihydrofolate reductase, CHLORIDE ION, MAGNESIUM ION, ...
著者Cao, H., Rodrigues, J., Benach, J., Frommelt, A., Morisco, L., Koss, J., Shakhnovich, E., Skolnick, J.
登録日2018-10-12
公開日2019-05-15
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Time-resolved x-ray crystallography capture of a slow reaction tetrahydrofolate intermediate.
Struct Dyn., 6, 2019
6MT8
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E. COLI DHFR COMPLEX MODELED WITH TWO LIGAND STATES
分子名称:Dihydrofolate reductase, CHLORIDE ION, MAGNESIUM ION, ...
著者Cao, H., Rodrigues, J., Benach, J., Frommelt, A., Morisco, L., Koss, J., Shakhnovich, E., Skolnick, J.
登録日2018-10-19
公開日2019-05-15
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Time-resolved x-ray crystallography capture of a slow reaction tetrahydrofolate intermediate.
Struct Dyn., 6, 2019
6MTH
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E. COLI DHFR COMPLEX MODELED WITH THREE LIGAND STATES
分子名称:Dihydrofolate reductase, CHLORIDE ION, MAGNESIUM ION, ...
著者Cao, H., Rodrigues, J., Benach, J., Frommelt, A., Morisco, L., Koss, J., Shakhnovich, E., Skolnick, J.
登録日2018-10-19
公開日2019-05-15
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Time-resolved x-ray crystallography capture of a slow reaction tetrahydrofolate intermediate.
Struct Dyn., 6, 2019
4OO2
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STREPTOMYCES GLOBISPORUS C-1027 FAD DEPENDENT (S)-3-CHLORO-β-TYROSINE-S-SGCC2 C-5 HYDROXYLASE SGCC APO FORM
分子名称:Chlorophenol-4-monooxygenase, CALCIUM ION, GLYCEROL
著者Cao, H., Xu, W., Bingman, C., Lohman, J.R., Yennamalli, R., Shen, B., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2014-01-29
公開日2014-02-12
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.
Biochemistry, 55, 2016
4PYT
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CRYSTAL STRUCTURE OF A MURB FAMILY EP-UDP-N-ACETYLGLUCOSAMINE REDUCTASE
分子名称:UDP-N-acetylenolpyruvoylglucosamine reductase, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ...
著者Cao, H., Franz, L., Sen, S., Bingman, C., Auldridge, M., Steinmetz, E., Mead, D., Phillips Jr., G.N.
登録日2014-03-27
公開日2014-05-21
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.853 Å)
主引用文献LucY: A Versatile New Fluorescent Reporter Protein.
Plos One, 10, 2015
5INJ
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CRYSTAL STRUCTURE OF PRENYLTRANSFERASE PRIB TERNARY COMPLEX WITH L-TRYPTOPHAN AND DIMETHYLALLYL THIOLODIPHOSPHATE (DMSPP)
分子名称:Prenyltransferase, TRYPTOPHAN, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
著者Cao, H., Elshahawi, S., Benach, J., Wasserman, S.R., Morisco, L.L., Koss, J.W., Thorson, J.S., Phillips, G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2016-03-07
公開日2016-05-11
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure and specificity of a permissive bacterial C-prenyltransferase.
Nat. Chem. Biol., 13, 2017
5JXM
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CRYSTAL STRUCTURE OF PRENYLTRANSFERASE PRIB APO FORM
分子名称:PriB, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION
著者Cao, H., Elshahawi, S., Benach, J., Wasserman, S.R., Morisco, L.L., Koss, J.W., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2016-05-13
公開日2016-06-08
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Structure and specificity of a permissive bacterial C-prenyltransferase.
Nat. Chem. Biol., 13, 2017
5K9M
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CRYSTAL STRUCTURE OF PRIB BINARY COMPLEX WITH PRODUCT DIPHOSPHATE
分子名称:PriB Prenyltransferase, PYROPHOSPHATE 2-, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
著者Cao, H., Elshahawi, S., Benach, J., Wasserman, S.R., Morisco, L.L., Koss, J.W., Thorson, J.S., Phillips, G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2016-06-01
公開日2016-06-15
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure and specificity of a permissive bacterial C-prenyltransferase.
Nat. Chem. Biol., 13, 2017
2I0A
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CRYSTAL STRUCTURE OF KB-19 COMPLEXED WITH WILD TYPE HIV-1 PROTEASE
分子名称:Protease, PHOSPHATE ION, (5S)-3-(4-ACETYLPHENYL)-N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]-2-OXO-1,3-OXAZOLIDINE-5-CARBOXAMIDE, ...
著者Nalam, M.N.L., Schiffer, C.A., Ali, A., Reddy, K.K., Cao, H., Anjum, S.G., Rana, T.M.
登録日2006-08-10
公開日2006-12-19
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of HIV-1 Protease Inhibitors with Picomolar Affinities Incorporating N-Aryl-oxazolidinone-5-carboxamides as Novel P2 Ligands.
J.Med.Chem., 49, 2006