6CYV

E. coli DHFR ternary complex with NADP and dihydrofolate

Summary for 6CYV

• Entry DOI: 10.2210/pdb6cyv/pdb
• Related: 6CW7 6CXK
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, DIHYDROFOLIC ACID, ... (4 entities in total)
• Functional Keywords: dhfr, dihydrofolate reductase, dihydrofolate, nadp, ternary complex, oxidoreductase
• Biological source: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
• Total number of polymer chains: 1
• Total formula weight: 20035.04

Authors

Cao, H.,Rodrigues, J.,Benach, J.,Frommelt, A.,Morisco, L.,Koss, J.,Shakhnovich, E.,Skolnick, J. (deposition date: 2018-04-06, release date: 2019-01-09, Last modification date: 2023-10-04)

• Primary citation: Cao, H.,Gao, M.,Zhou, H.,Skolnick, J.; The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release.; Commun Biol, 1:226-226, 2018; PubMed: 30564747; DOI: 10.1038/s42003-018-0236-y

Experimental method

X-RAY DIFFRACTION (1.3 Å)