Author results

2PNU
  • Download 2pnu
  • View 2pnu
Molmil generated image of 2pnu
CRYSTAL STRUCTURE OF HUMAN ANDROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH EM-5744
Descriptor:Androgen receptor, SULFATE ION, (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE, ...
Authors:Cantin, L., Faucher, F., Couture, J.F., Pereira de Jesus-Tran, K., Legrand, P., Ciobanu, C.L., Singh, S.M., Labrie, F., Breton, R.
Deposit date:2007-04-25
Release date:2007-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Characterization of the Human Androgen Receptor Ligand-binding Domain Complexed with EM5744, a Rationally Designed Steroidal Ligand Bearing a Bulky Chain Directed toward Helix 12.
J.Biol.Chem., 282, 2007
1MRQ
  • Download 1mrq
  • View 1mrq
Molmil generated image of 1mrq
CRYSTAL STRUCTURE OF HUMAN 20ALPHA-HSD IN TERNARY COMPLEX WITH NADP AND 20ALPHA-HYDROXY-PROGESTERONE
Descriptor:Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, ...
Authors:Couture, J.F., Legrand, P., Cantin, L., Luu-The, V., Labrie, F., Breton, R.
Deposit date:2002-09-18
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids.
J.Mol.Biol., 331, 2003
1Q13
  • Download 1q13
  • View 1q13
Molmil generated image of 1q13
CRYSTAL STRUCTURE OF RABBIT 20ALPHA HYROXYSTEROID DEHYDROGENASE IN TERNARY COMPLEX WITH NADP AND TESTOSTERONE
Descriptor:Prostaglandin-E2 9-reductase, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Couture, J.-F., Cantin, L., Legrand, P., Luu-The, V., Labrie, F., Breton, R.
Deposit date:2003-07-18
Release date:2004-11-16
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily.
J. Mol. Biol., 339, 2004
1Q5M
  • Download 1q5m
  • View 1q5m
Molmil generated image of 1q5m
BINARY COMPLEX OF RABBIT 20ALPHA-HYDROXYSTEROID DEHYDROGENASE WITH NADPH
Descriptor:Prostaglandin-E2 9-reductase, SULFATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Couture, J.F., Legrand, P., Cantin, L., Labrie, F., Luu-The, V., Breton, R.
Deposit date:2003-08-08
Release date:2004-05-18
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Loop Relaxation, A Mechanism that Explains the Reduced Specificity of Rabbit 20alpha-Hydroxysteroid Dehydrogenase, A Member of the Aldo-Keto Reductase Superfamily.
J.Mol.Biol., 339, 2004
1XJB
  • Download 1xjb
  • View 1xjb
Molmil generated image of 1xjb
CRYSTAL STRUCTURE OF HUMAN TYPE 3 3ALPHA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP(H), CITRATE AND ACETATE MOLECULES
Descriptor:Aldo-keto reductase family 1 member C2, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Couture, J.-F., Pereira de Jesus-Tran, K., Roy, A.-M., Legrand, P., Cantin, L., Cote, P.-L., Luu-The, V., Labrie, F., Breton, R.
Deposit date:2004-09-23
Release date:2005-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen
Protein Sci., 14, 2005
2AM9
  • Download 2am9
  • View 2am9
Molmil generated image of 2am9
CRYSTAL STRUCTURE OF HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH TESTOSTERONE
Descriptor:Androgen receptor, SULFATE ION, TESTOSTERONE, ...
Authors:Pereira de Jesus-Tran, K., Cote, P.-L., Cantin, L., Blanchet, J., Labrie, F., Breton, R.
Deposit date:2005-08-09
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15, 2006
2AMA
  • Download 2ama
  • View 2ama
Molmil generated image of 2ama
CRYSTAL STRUCTURE OF HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH DIHYDROTESTOSTERONE
Descriptor:Androgen receptor, SULFATE ION, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Pereira de Jesus-Tran, K., Cote, P.-L., Cantin, L., Blanchet, J., Labrie, F., Breton, R.
Deposit date:2005-08-09
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15, 2006
2AMB
  • Download 2amb
  • View 2amb
Molmil generated image of 2amb
CRYSTAL STRUCTURE OF HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH TETRAHYDROGESTRINONE
Descriptor:Androgen receptor, SULFATE ION, 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE, ...
Authors:Pereira de Jesus-Tran, K., Cote, P.-L., Cantin, L., Blanchet, J., Labrie, F., Breton, R.
Deposit date:2005-08-09
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15, 2006
2HDJ
  • Download 2hdj
  • View 2hdj
Molmil generated image of 2hdj
CRYSTAL STRUCTURE OF HUMAN TYPE 3 3ALPHA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP(H)
Descriptor:Aldo-keto reductase family 1 member C2, SULFATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Faucher, F., Pereira de Jesus-Tran, K., Cantin, L., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-06-20
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.
J.Mol.Biol., 364, 2006
2HE5
  • Download 2he5
  • View 2he5
Molmil generated image of 2he5
CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE IN BINARY COMPLEX WITH NADP(H) IN AN OPEN CONFORMATION
Descriptor:Aldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Faucher, F., Pereira de Jesus-Tran, K., Cantin, L., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-06-21
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.
J.Mol.Biol., 364, 2006
2HE8
  • Download 2he8
  • View 2he8
Molmil generated image of 2he8
CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE IN ITS APO-FORM
Descriptor:Aldo-keto reductase family 1, member C21, ACETATE ION, ...
Authors:Faucher, F., Pereira de Jesus-Tran, K., Cantin, L., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-06-21
Release date:2006-12-05
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.
J.Mol.Biol., 364, 2006
2HEJ
  • Download 2hej
  • View 2hej
Molmil generated image of 2hej
CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP(H) IN A CLOSED CONFORMATION
Descriptor:Aldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Faucher, F., Pereira de Jesus-Tran, K., Cantin, L., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-06-21
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.
J.Mol.Biol., 364, 2006
2IPF
  • Download 2ipf
  • View 2ipf
Molmil generated image of 2ipf
CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP+ AND EPI-TESTOSTERONE
Descriptor:(3(17)alpha-hydroxysteroid dehydrogenase), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE, ...
Authors:Faucher, F., Cantin, L., Pereira de Jesus-Tran, K., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-10-12
Release date:2007-06-19
Last modified:2012-05-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding.
J.Mol.Biol., 369, 2007
2IPG
  • Download 2ipg
  • View 2ipg
Molmil generated image of 2ipg
CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE MUTANT K31A IN COMPLEX WITH NADP+ AND EPI-TESTOSTERONE
Descriptor:3(17)alpha-hydroxysteroid dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE, ...
Authors:Faucher, F., Cantin, L., Pereira de Jesus-Tran, K., Lemieux, M., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-10-12
Release date:2007-06-19
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding.
J.Mol.Biol., 369, 2007
2IPJ
  • Download 2ipj
  • View 2ipj
Molmil generated image of 2ipj
CRYSTAL STRUCTURE OF H3ALPHA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 MUTANT Y24A IN COMPLEX WITH NADP+ AND EPI-TESTOSTERONE
Descriptor:Aldo-keto reductase family 1 member C2, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Faucher, F., Cantin, L., Pereira de Jesus-Tran, K., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-10-12
Release date:2007-06-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding.
J.Mol.Biol., 369, 2007
3CAQ
  • Download 3caq
  • View 3caq
Molmil generated image of 3caq
CRYSTAL STRUCTURE OF 5BETA-REDUCTASE (AKR1D1) IN COMPLEX WITH NADPH
Descriptor:3-oxo-5-beta-steroid 4-dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, BETA-MERCAPTOETHANOL, ...
Authors:Faucher, F., Cantin, L., Breton, R.
Deposit date:2008-02-20
Release date:2008-12-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of Human Delta4-3-Ketosteroid 5beta-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substrate Inhibition (dagger) (,) (double dagger).
Biochemistry, 47, 2008
3CAS
  • Download 3cas
  • View 3cas
Molmil generated image of 3cas
CRYSTAL STRUCTURE OF 5BETA-REDUCTASE (AKR1D1) IN COMPLEX WITH NADP+ AND 4-ANDROSTENEDIONE
Descriptor:3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, BETA-MERCAPTOETHANOL, ...
Authors:Faucher, F., Cantin, L., Breton, R.
Deposit date:2008-02-20
Release date:2008-12-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Human Delta4-3-Ketosteroid 5beta-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substrate Inhibition (dagger) (,) (double dagger).
Biochemistry, 47, 2008
3CAV
  • Download 3cav
  • View 3cav
Molmil generated image of 3cav
CRYSTAL STRUCTURE OF 5BETA-REDUCTASE (AKR1D1) IN COMPLEX WITH NADP+ AND 5BETA-PREGNAN-3,20-DIONE
Descriptor:3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5BETA)-PREGNANE-3,20-DIONE, ...
Authors:Faucher, F., Cantin, L., Breton, R.
Deposit date:2008-02-20
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism.
Biochemistry, 47, 2008
1J96
  • Download 1j96
  • View 1j96
Molmil generated image of 1j96
HUMAN 3ALPHA-HSD TYPE 3 IN TERNARY COMPLEX WITH NADP AND TESTOSTERONE
Descriptor:3alpha-hydroxysteroid dehydrogenase type 3, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Nahoum, V., Labrie, F., Lin, S.-X.
Deposit date:2001-05-23
Release date:2002-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.
J.Biol.Chem., 276, 2001