Author results

2YNK
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WZI, AN OUTER MEMBRANE PROTEIN INVOLVED IN GROUP 1 CAPSULE ASSEMBLY IN ESCHERICHIA COLI, IS A CARBOHYDRATE BINDING BETA-BARREL
Descriptor:WZI, N-OCTANE, DODECANE, ...
Authors:Bushell, S.R., Mainprize, I.L., Wear, M.A., Lou, H., Kong, L., Davis, B., Bayley, H., Whitfield, C., Naismith, J.H.
Deposit date:2012-10-16
Release date:2013-05-15
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Wzi is an Outer Membrane Lectin that Underpins Group 1 Capsule Assembly in Escherichia Coli.
Structure, 21, 2013
5OC9
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CRYSTAL STRUCTURE OF HUMAN TMEM16K / ANOCTAMIN 10
Descriptor:Anoctamin-10, CALCIUM ION, (2R)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate
Authors:Bushell, S.R., Pike, A.C.W., Chu, A., Tessitore, A., Rotty, B., Mukhopadhyay, S., Kupinska, K., Shrestha, L., Borkowska, O., Chalk, R., Burgess-Brown, N.A., Love, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2017-06-29
Release date:2018-07-25
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structure of human TMEM16K / Anoctamin 10
TO BE PUBLISHED
6R65
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CRYSTAL STRUCTURE OF HUMAN TMEM16K / ANOCTAMIN 10 (FORM 2)
Descriptor:Anoctamin-10, CALCIUM ION
Authors:Bushell, S.R., Pike, A.C.W., Chu, A., Tessitore, A., Rotty, B., Mukhopadhyay, S., Kupinska, K., Shrestha, L., Borkowska, O., Chalk, R., Burgess-Brown, N.A., Love, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-26
Release date:2019-05-01
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal Structure of human TMEM16K / Anoctamin 10 (Form 2)
TO BE PUBLISHED
6R7X
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CRYOEM STRUCTURE OF CALCIUM-BOUND HUMAN TMEM16K / ANOCTAMIN 10 IN DETERGENT (2MM CA2+, CLOSED FORM)
Descriptor:Anoctamin-10, CALCIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Baronina, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-29
Release date:2019-05-01
Last modified:2019-09-18
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Nat Commun, 10, 2019
6R7Y
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CRYOEM STRUCTURE OF CALCIUM-BOUND HUMAN TMEM16K / ANOCTAMIN 10 IN DETERGENT (LOW CA2+, CLOSED FORM)
Descriptor:Anoctamin-10, CALCIUM ION
Authors:Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-29
Release date:2019-05-01
Last modified:2019-09-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Nat Commun, 10, 2019
6R7Z
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CRYOEM STRUCTURE OF CALCIUM-FREE HUMAN TMEM16K / ANOCTAMIN 10 IN DETERGENT (CLOSED FORM)
Descriptor:Anoctamin-10
Authors:Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-29
Release date:2019-05-01
Last modified:2019-09-18
Method:ELECTRON MICROSCOPY (5.14 Å)
Cite:The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Nat Commun, 10, 2019
4TWK
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK1 (K2P2.1)
Descriptor:Potassium channel subfamily K member 2, POTASSIUM ION, Octyl Glucose Neopentyl Glycol, ...
Authors:Pike, A.C.W., Dong, Y.Y., Tessitore, A., Goubin, S., Strain-Damerell, C., Mukhopadhyay, S., Kupinska, K., Wang, D., Chalk, R., Berridge, G., Grieben, M., Shrestha, L., Ang, J.H., Mackenzie, A., Quigley, A., Bushell, S.R., Shintre, C.A., Faust, B., Chu, A., Dong, L., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P.
Deposit date:2014-06-30
Release date:2014-08-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)
To Be Published
6GYN
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STRUCTURE OF HUMAN HCN4 HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED ION CHANNEL
Descriptor:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
Authors:Shintre, C.A., Pike, A.C.W., Tessitore, A., Young, M., Bushell, S.R., Strain-Damerell, C., Mukhopadhyay, S., Burgess-Brown, N.A., Huiskonen, J.T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2018-06-30
Release date:2019-05-08
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
To Be Published
6GYO
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STRUCTURE OF HUMAN HCN4 HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED ION CHANNEL IN COMPLEX WITH CAMP
Descriptor:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Shintre, C.A., Pike, A.C.W., Tessitore, A., Young, M., Bushell, S.R., Strain-Damerell, C., Mukhopadhyay, S., Burgess-Brown, N.A., Huiskonen, J.T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2018-06-30
Release date:2019-05-01
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
To Be Published
3A3T
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THE OXIDOREDUCTASE NMDSBA1 FROM N. MENINGITIDIS
Descriptor:Thiol:disulfide interchange protein DsbA
Authors:Vivian, J.P., Scoullar, J., Bushell, S., Beddoe, T., Wilce, M.C.J., Byres, E., Boyle, T.P., Rimmer, K., Doak, B., Simpson, J.S., Graham, B., Heras, B., Kahler, C.M., Rossjohn, J., Scanlon, M.J.
Deposit date:2009-06-19
Release date:2009-10-20
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis
J.Mol.Biol., 394, 2009
2XE1
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MOLECULAR INSIGHTS INTO CLINICALLY ISOLATED OMPC MUTANTS AND THEIR ROLE IN MULTI-DRUG RESISTANCE
Descriptor:OUTER MEMBRANE PROTEIN C, DECANE, HEXANE
Authors:Bamford, V.A., Naismith, J.H.
Deposit date:2010-05-10
Release date:2010-05-19
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Altered Antibiotic Transport in Ompc Mutants Isolated from a Series of Clinical Strains of Multi-Drug Resistant E. Coli.
Plos One, 6, 2011
2XE2
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MOLECULAR INSIGHTS INTO CLINICALLY ISOLATED OMPC20 MUTANTS AND THEIR ROLE IN MULTI-DRUG RESISTANCE
Descriptor:OUTER MEMBRANE PORIN C, N-OCTYL-2-HYDROXYETHYL SULFOXIDE
Authors:Bamford, V.A., Naismith, J.H.
Deposit date:2010-05-10
Release date:2010-05-19
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Altered Antibiotic Transport in Ompc Mutants Isolated from a Series of Clinical Strains of Multi-Drug Resistant E. Coli.
Plos One, 6, 2011
2XE3
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OMPC28
Descriptor:OUTER MEMBRANE PORIN C, B-OCTYLGLUCOSIDE
Authors:Lou, H., Naismith, J.H.
Deposit date:2010-05-10
Release date:2010-05-19
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Altered Antibiotic Transport in Ompc Mutants Isolated from a Series of Clinical Strains of Multi-Drug Resistant E. Coli.
Plos One, 6, 2011
2XE5
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MOLECULAR INSIGHTS INTO CLINICALLY ISOLATED OMPC MUTANTS AND THEIR ROLE IN MULTI-DRUG RESISTANCE (OMPC26)
Descriptor:OUTER MEMBRANE PORIN C, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, HEXANE, ...
Authors:Bamford, V.A., Naismith, J.H.
Deposit date:2010-05-11
Release date:2010-05-26
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Altered Antibiotic Transport in Ompc Mutants Isolated from a Series of Clinical Strains of Multi-Drug Resistant E. Coli.
Plos One, 6, 2011
2XG6
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MOLECULAR INSIGHTS INTO CLINICALLY ISOLATED OMPC MUTANTS AND THEIR ROLE IN MULTI-DRUG RESISTANCE
Descriptor:OMPC, SULFATE ION
Authors:Lou, H., Naismith, J.H.
Deposit date:2010-05-31
Release date:2010-07-14
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (3.47 Å)
Cite:Altered Antibiotic Transport in Ompc Mutants Isolated from a Series of Clinical Strains of Multi-Drug Resistant E. Coli.
Plos One, 6, 2011
5MP0
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HUMAN M7GPPPN-MRNA HYDROLASE (DCP2, NUDT20) CATALYTIC DOMAIN
Descriptor:m7GpppN-mRNA hydrolase, 1,2-ETHANEDIOL
Authors:Mathea, S., Salah, E., Velupillai, S., Tallant, C., Pike, A.C.W., Bushell, S.R., Faust, B., Wang, D., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Huber, K.
Deposit date:2016-12-15
Release date:2017-06-28
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Human m7GpppN-mRNA Hydrolase (DCP2, NUDT20) Catalytic Domain
To Be Published
6RV2
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CRYSTAL STRUCTURE OF THE HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TASK-1 (K2P3.1) IN A CLOSED CONFORMATION
Descriptor:Potassium channel subfamily K member 3, POTASSIUM ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Rodstrom, K.E.J., Pike, A.C.W., Zhang, W., Quigley, A., Speedman, D., Mukhopadhyay, S.M.M., Shrestha, L., Chalk, R., Venkaya, S., Bushell, S.R., Tessitore, A., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:A unique lower X-gate in TASK channels sequesters inhibitors within the vestibule
TO BE PUBLISHED
6RV3
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CRYSTAL STRUCTURE OF THE HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TASK-1 (K2P3.1) IN A CLOSED CONFORMATION WITH A BOUND INHIBITOR BAY 1000493
Descriptor:Potassium channel subfamily K member 3, POTASSIUM ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Rodstrom, K.E.J., Pike, A.C.W., Zhang, W., Quigley, A., Speedman, D., Mukhopadhyay, S.M.M., Shrestha, L., Chalk, R., Venkaya, S., Bushell, S.R., Tessitore, A., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A unique lower X-gate in TASK channels sequesters inhibitors within the vestibule
To Be Published
6RV4
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CRYSTAL STRUCTURE OF THE HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TASK-1 (K2P3.1) IN A CLOSED CONFORMATION WITH A BOUND INHIBITOR BAY 2341237
Descriptor:Potassium channel subfamily K member 3, POTASSIUM ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Rodstrom, K.E.J., Pike, A.C.W., Zhang, W., Quigley, A., Speedman, D., Mukhopadhyay, S.M.M., Shrestha, L., Chalk, R., Venkaya, S., Bushell, S.R., Tessitore, A., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A unique lower X-gate in TASK channels sequesters inhibitors within the vestibule
To Be Published