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6BWW
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CRYSTAL STRUCTURE OF AN ACETATE AND CYMAL-5 BOUND CYTOCHROME P450 2B4 F429H MUTANT
分子名称:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ...
著者Yang, Y.T., Waskell, L.
登録日2017-12-15
公開日2018-12-19
最終更新日2019-07-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of cytochrome P450 2B4 with an acetate ligand and an active site hydrogen bond network similar to oxyferrous P450cam.
J.Inorg.Biochem., 185, 2018
5AGR
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT (S)-3-(AMINOMETHYL)-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
分子名称:LEUCINE--TRNA LIGASE, METHIONINE, LEUCINE, ...
著者Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
登録日2015-02-03
公開日2016-03-02
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGS
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
分子名称:LEUCYL-TRNA SYNTHETASE, METHIONINE, 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-MODIFIED ADENOSINE
著者Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
登録日2015-02-03
公開日2016-03-09
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGT
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT (S)-3-(AMINOMETHYL)-4-CHLORO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
分子名称:LEUCINE--TRNA LIGASE, METHIONINE, 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, ...
著者Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
登録日2015-02-03
公開日2016-03-02
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
4D6V
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CRYSTAL STRUCTURE OF SIGNAL TRANSDUCING PROTEIN
分子名称:G PROTEIN BETA SUBUNIT GIB2
著者Ero, R., Dimitrova, V.T., Chen, Y., Bu, W., Feng, S., Liu, T., Wang, P., Xue, C., Tan, S.M., Gao, Y.G.
登録日2014-11-17
公開日2015-03-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of Gib2, a Signal-Transducing Protein Scaffold Associated with Ribosomes in Cryptococcus Neoformans.
Sci.Rep., 5, 2015
4MGJ
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CRYSTAL STRUCTURE OF CYTOCHROME P450 2B4 F429H IN COMPLEX WITH 4-CPI
分子名称:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-CHLOROPHENYL)IMIDAZOLE
著者Yang, Y., Zhang, H., Usharani, D., Bu, W., Im, S., Tarasev, M., Rwere, F., Meagher, J., Sun, C., Stuckey, J., Shaik, S., Waskell, L.
登録日2013-08-28
公開日2014-08-13
最終更新日2014-09-24
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Structural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate-Histidine Hydrogen Bond.
Biochemistry, 53, 2014
4L6Q
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ROCK2 IN COMPLEX WITH BENZOXABOROLE
分子名称:Rho-associated protein kinase 2, 6-[4-(aminomethyl)-2-fluorophenoxy]-2,1-benzoxaborol-1(3H)-ol
著者Rock, F., Jarnagin, K.
登録日2013-06-12
公開日2013-10-02
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Linking phenotype to kinase: identification of a novel benzoxaborole hinge-binding motif for kinase inhibition and development of high-potency rho kinase inhibitors.
J.Pharmacol.Exp.Ther., 347, 2013
3ZJT
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TERNARY COMPLEX OF E.COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU)574 AND THE BENZOXABOROLE AN3017 IN THE EDITING CONFORMATION
分子名称:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJU
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3016 IN THE EDITING CONFORMATION
分子名称:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJV
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3213 IN THE EDITING CONFORMATION
分子名称:LEUCINE--TRNA LIGASE, TRNALEU5 UAA ISOACCEPTOR
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
4DE6
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HORSE SPLEEN APO-FERRITIN COMPLEX WITH ARACHIDONIC ACID
分子名称:Ferritin light chain, ARACHIDONIC ACID, CADMIUM ION, ...
著者Bu, W., Liu, R., Dmochowski, I.J., Loll, P.J., Eckenhoff, R.G.
登録日2012-01-19
公開日2012-03-07
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Ferritin couples iron and fatty acid metabolism.
Faseb J., 26, 2012
3U90
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APOFERRITIN: COMPLEX WITH SDS
分子名称:Ferritin light chain, DODECYL SULFATE, CADMIUM ION
著者Liu, R., Bu, W., Xi, J., Mortazavi, S.R., Cheung-Lau, J.C., Dmochowski, I.J., Loll, P.J.
登録日2011-10-17
公開日2012-04-25
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Beyond the detergent effect: a binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritin.
Acta Crystallogr.,Sect.D, 68, 2012
3KVR
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
分子名称:Uridine phosphorylase, 5-FLUOROURACIL, SULFATE ION, ...
著者Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
登録日2009-11-30
公開日2010-04-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
3KVV
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
分子名称:Uridine phosphorylase, 5-FLUOROURACIL, SULFATE ION, ...
著者Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
登録日2009-11-30
公開日2010-04-28
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
3KVY
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
分子名称:Uridine Phosphorylase, SULFATE ION, URACIL, ...
著者Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
登録日2009-11-30
公開日2010-04-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
3KUK
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
分子名称:Uridine phosphorylase, SULFATE ION, 2'-DEOXYURIDINE
著者Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
登録日2009-11-27
公開日2010-04-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.783 Å)
主引用文献Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
3KU4
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
分子名称:Uridine phosphorylase, SULFATE ION
著者Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
登録日2009-11-26
公開日2010-04-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
3H0R
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STRUCTURE OF TRNA-DEPENDENT AMIDOTRANSFERASE GATCAB FROM AQUIFEX AEOLICUS
分子名称:Glutamyl-tRNA(Gln) amidotransferase subunit A, Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Glutamyl-tRNA(Gln) amidotransferase subunit C, ...
著者Wu, J., Bu, W., Sheppard, K., Kitabatake, M., Soll, D., Smith, J.L.
登録日2009-04-10
公開日2009-07-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Insights into tRNA-Dependent Amidotransferase Evolution and Catalysis from the Structure of the Aquifex aeolicus Enzyme
J.Mol.Biol., 391, 2009
3H0L
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STRUCTURE OF TRNA-DEPENDENT AMIDOTRANSFERASE GATCAB FROM AQUIFEX AEOLICUS
分子名称:Glutamyl-tRNA(Gln) amidotransferase subunit A, Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Glutamyl-tRNA(Gln) amidotransferase subunit C, ...
著者Wu, J., Bu, W., Sheppard, K., Kitabatake, M., Soll, D., Smith, J.L.
登録日2009-04-09
公開日2009-07-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insights into tRNA-Dependent Amidotransferase Evolution and Catalysis from the Structure of the Aquifex aeolicus Enzyme
J.Mol.Biol., 391, 2009
3H0M
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STRUCTURE OF TRNA-DEPENDENT AMIDOTRANSFERASE GATCAB FROM AQUIFEX AEOLICUS
分子名称:Glutamyl-tRNA(Gln) amidotransferase subunit A, Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Glutamyl-tRNA(Gln) amidotransferase subunit C, ...
著者Wu, J., Bu, W., Sheppard, K., Kitabatake, M., Soll, D., Smith, J.L.
登録日2009-04-09
公開日2009-07-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Insights into tRNA-Dependent Amidotransferase Evolution and Catalysis from the Structure of the Aquifex aeolicus Enzyme
J.Mol.Biol., 391, 2009
3D26
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NORWALK P DOMAIN A-TRISACCHARIDE COMPLEX
分子名称:58 kd capsid protein, N-ACETYL-D-GALACTOSAMINE, BETA-D-GALACTOSE, ...
著者Hegde, R., Bu, W.
登録日2008-05-07
公開日2008-06-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for the receptor binding specificity of Norwalk virus.
J.Virol., 82, 2008
3BY1
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UNLIGANDED NORVALK VIRUS P DOMAIN
分子名称:58 kd capsid protein
著者Hegde, R., Bu, W.
登録日2008-01-15
公開日2008-04-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Structural basis for the receptor binding specificity of Norwalk virus.
J.Virol., 82, 2008
3BY2
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NORWALK P POLYPEPTIDE (228-523)
分子名称:58 kd capsid protein
著者Hegde, R., Bu, W.
登録日2008-01-15
公開日2008-04-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for the receptor binding specificity of Norwalk virus.
J.Virol., 82, 2008
3BQJ
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VA387 POLYPEPTIDE
分子名称:va387 polypeptide
著者Bu, W., Mamedova, A., Tan, M., Jiang, J., Hegde, R.
登録日2007-12-20
公開日2008-04-22
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for the receptor binding specificity of Norwalk virus.
J.Virol., 82, 2008
1U1C
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STRUCTURE OF E. COLI URIDINE PHOSPHORYLASE COMPLEXED TO 5-BENZYLACYCLOURIDINE (BAU)
分子名称:Uridine phosphorylase, PHOSPHATE ION, POTASSIUM ION, ...
著者Bu, W., Settembre, E.C., Ealick, S.E.
登録日2004-07-15
公開日2005-07-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines.
Acta Crystallogr.,Sect.D, 61, 2005
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