Author results

1TYA
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STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS
Descriptor:TYROSYL-tRNA SYNTHETASE, TYROSINE
Authors:Brown, K.A., De Meester, P., Blow, D.M.
Deposit date:1992-07-06
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions
To be Published
1TYB
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STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS
Descriptor:TYROSYL-tRNA SYNTHETASE, TYROSINE
Authors:Brown, K.A., De Meester, P., Blow, D.M.
Deposit date:1992-07-06
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions
To be Published
1TYC
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STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS
Descriptor:TYROSYL-tRNA SYNTHETASE
Authors:Brown, K.A., Brick, P., De Meester, P., Blow, D.M.
Deposit date:1992-07-06
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions
To be Published
1DHJ
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LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:Brown, K.A., Kraut, J.
Deposit date:1993-10-29
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase.
Proc.Natl.Acad.Sci.USA, 90, 1993
1DHI
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LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:Oatley, S.J., Villafranca, J.E., Brown, K.A., Kraut, J.
Deposit date:1993-10-29
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase.
Proc.Natl.Acad.Sci.USA, 90, 1993
2DRC
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INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:Brown, K.A., Kraut, J.
Deposit date:1992-06-10
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
Biochemistry, 30, 1991
1TYD
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STRUCTURE OF TYROSYL-TRNA SYNTHETASE REFINED AT 2.3 ANGSTROMS RESOLUTION. INTERACTION OF THE ENZYME WITH THE TYROSYL ADENYLATE INTERMEDIATE
Descriptor:TYROSYL-tRNA SYNTHETASE, TYROSINE
Authors:Brown, K.A., De Meester, P., Blow, D.M.
Deposit date:1992-07-06
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate.
J.Mol.Biol., 208, 1989
1DQS
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CRYSTAL STRUCTURE OF DEHYDROQUINATE SYNTHASE (DHQS) COMPLEXED WITH CARBAPHOSPHONATE, NAD+ AND ZN2+
Descriptor:PROTEIN (3-DEHYDROQUINATE SYNTHASE), ZINC ION, CHLORIDE ION, ...
Authors:Carpenter, E.P., Hawkins, A.R., Frost, J.W., Brown, K.A.
Deposit date:1998-04-09
Release date:1999-07-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis.
Nature, 394, 1998
1SJ2
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS CATALASE-PEROXIDASE
Descriptor:Peroxidase/catalase T, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL
Authors:Bertrand, T., Eady, N.A.J., Jones, J.N., Bodiguel, J., Jesmin, Nagy, J.M., Raven, E.L., Jamart-Gregoire, B., Brown, K.A.
Deposit date:2004-03-02
Release date:2004-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal Structure of Mycobacterium tuberculosis Catalase-Peroxidase.
J.Biol.Chem., 279, 2004
2QJ6
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CRYSTAL STRUCTURE ANALYSIS OF A 14 REPEAT C-TERMINAL FRAGMENT OF TOXIN TCDA IN CLOSTRIDIUM DIFFICILE
Descriptor:Toxin A
Authors:Albesa-Jove, D., Bertrand, T., Carpenter, L., Lim, J., Brown, K.A., Fairweather, N.
Deposit date:2007-07-06
Release date:2008-07-15
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Solution and crystal structures of the cell binding domain of toxins TcdA and TcdB from Clostridium difficile
To be Published
2V23
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STRUCTURE OF CYTOCHROME C PEROXIDASE MUTANT N184R Y36A
Descriptor:CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Metcalfe, C.L., Macdonald, I.K., Brown, K.A., Raven, E.L., Moody, P.C.E.
Deposit date:2007-05-31
Release date:2007-12-04
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Tuberculosis Prodrug Isoniazid Bound to Activating Peroxidases.
J.Biol.Chem., 283, 2008
2V2E
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STRUCTURE OF ISONIAZID (INH) BOUND TO CYTOCHROME C PEROXIDASE MUTANT N184R Y36A
Descriptor:CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE, 4-(DIAZENYLCARBONYL)PYRIDINE
Authors:Metcalfe, C.L., Macdonald, I.K., Brown, K.A., Raven, E.L., Moody, P.C.E.
Deposit date:2007-06-05
Release date:2007-12-04
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:The Tuberculosis Prodrug Isoniazid Bound to Activating Peroxidases.
J.Biol.Chem., 283, 2008
2VCF
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STRUCTURE OF ISONIAZID (INH) BOUND TO CYTOSOLIC SOYBEAN ASCORBATE PEROXIDASE
Descriptor:ASCORBATE PEROXIDASE FROM SOYBEAN CYTOSOL, 4-(DIAZENYLCARBONYL)PYRIDINE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Metcalfe, C.L., Macdonald, I.K., Brown, K.A., Raven, E.L., Moody, P.C.E.
Deposit date:2007-09-21
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Tuberculosis Prodrug Isoniazid Bound to Activating Peroxidases.
J.Biol.Chem., 283, 2008
2VCN
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STRUCTURE OF ISONIAZID (INH) BOUND TO CYTOSOLIC SOYBEAN ASCORBATE PEROXIDASE MUTANT W41A
Descriptor:ASCORBATE PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ...
Authors:Metcalfe, C.L., Macdonald, I.K., Brown, K.A., Raven, E.L., Moody, P.C.E.
Deposit date:2007-09-25
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The Tuberculosis Prodrug Isoniazid Bound to Activating Peroxidases.
J.Biol.Chem., 283, 2008
2VCS
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STRUCTURE OF ISONIAZID (INH) BOUND TO CYTOSOLIC SOYBEAN ASCORBATE PEROXIDASE MUTANT H42A
Descriptor:ASCORBATE PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE, 4-(DIAZENYLCARBONYL)PYRIDINE, ...
Authors:Metcalfe, C.L., Macdonald, I.K., Brown, K.A., Raven, E.L., Moody, P.C.E.
Deposit date:2007-09-26
Release date:2007-12-04
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:The Tuberculosis Prodrug Isoniazid Bound to Activating Peroxidases.
J.Biol.Chem., 283, 2008
2X43
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STRUCTURAL BASIS OF MOLECULAR RECOGNITION BY SHERP AT MEMBRANE SURFACES
Descriptor:SHERP
Authors:Moore, B., Miles, A.J., Guerra, C.G., Simpson, P., Iwata, M., Wallace, B.A., Matthews, S.J., Smith, D.F., Brown, K.A.
Deposit date:2010-02-09
Release date:2010-11-24
Last modified:2017-04-19
Method:SOLUTION NMR
Cite:Structural Basis of Moelcular Recognition by the Leishmania Small Hydrophilic Endoplasmic Reticulum-Associated Protein, Sherp, at Membrane Surfaces
J.Biol.Chem., 286, 2011
2Z22
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CRYSTAL STRUCTURE OF PHOSPHATE PREPLASMIC BINDING PROTEIN PSTS FROM YERSINIA PESTIS
Descriptor:Periplasmic phosphate-binding protein, PHOSPHATE ION
Authors:Tanabe, M., Byrne, B., Brown, K.A., Mirza, O., Bertland, T.
Deposit date:2007-05-17
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains.
Acta Crystallogr.,Sect.D, 63, 2007
2Z23
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CRYSTAL STRUCTURE OF Y.PESTIS OLIGO PEPTIDE BINDING PROTEIN OPPA WITH TRI-LYSINE LIGAND
Descriptor:Periplasmic oligopeptide-binding protein, peptide (LYS)(LYS)(LYS)
Authors:Tanabe, M., Bertland, T., Mirza, O., Byrne, B., Brown, K.A.
Deposit date:2007-05-17
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains.
Acta Crystallogr.,Sect.D, 63, 2007
5CCP
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HISTIDINE 52 IS A CRITICAL RESIDUE FOR RAPID FORMATION OF CYTOCHROME C PEROXIDASE COMPOUND I
Descriptor:CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Brown, K., Shaw, A., Miller, M.A., Kraut, J.
Deposit date:1993-06-07
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Histidine 52 is a critical residue for rapid formation of cytochrome c peroxidase compound I.
Biochemistry, 32, 1993
1DRH
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ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Descriptor:DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sawaya, M.R., Kraut, J.
Deposit date:1994-11-30
Release date:1995-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
1DYH
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ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, 5-DEAZAFOLIC ACID, ...
Authors:Reyes, V.M., Kraut, J.
Deposit date:1994-10-26
Release date:1995-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
1DYI
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ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, FOLIC ACID, ...
Authors:Reyes, V.M., Kraut, J.
Deposit date:1994-10-26
Release date:1995-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
1DYJ
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ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, 5,10-DIDEAZATETRAHYDROFOLIC ACID, ...
Authors:Reyes, V.M., Kraut, J.
Deposit date:1994-10-26
Release date:1995-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
1V0H
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ASCOBATE PEROXIDASE FROM SOYBEAN CYTOSOL IN COMPLEX WITH SALICYLHYDROXAMIC ACID
Descriptor:ASCORBATE PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION, ...
Authors:Sharp, K.H., Raven, E.L., Moody, P.C.E.
Deposit date:2004-03-29
Release date:2004-06-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Crystal Structure of the Ascorbate Peroxidase-Salicylhydroxamic Acid Complex
Biochemistry, 43, 2004
3CVZ
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STRUCTURAL INSIGHTS INTO THE MOLECULAR ORGANIZATION OF THE S-LAYER FROM CLOSTRIDIUM DIFFICILE
Descriptor:S-layer protein, PHOSPHATE ION, GLYCINE
Authors:Albesa-Jove, D., Fagan, R.
Deposit date:2008-04-20
Release date:2009-03-17
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insights into the molecular organization of the S-layer from Clostridium difficile
Mol.Microbiol., 71, 2009
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