3DRC
INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS
Summary for 3DRC
Entry DOI | 10.2210/pdb3drc/pdb |
Descriptor | DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ... (5 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 37060.51 |
Authors | Oatley, S.J.,Kraut, J. (deposition date: 1992-09-22, release date: 1994-01-31, Last modification date: 2024-02-21) |
Primary citation | Warren, M.S.,Brown, K.A.,Farnum, M.F.,Howell, E.E.,Kraut, J. Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis. Biochemistry, 30:11092-11103, 1991 Cited by PubMed: 1932031DOI: 10.1021/bi00110a011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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