4ZS7
 
 | | Structural mimicry of receptor interaction by antagonistic IL-6 antibodies | | Descriptor: | Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain | | Authors: | Blanchetot, C, De Jonge, N, Desmyter, A, Ongenae, N, Hofman, E, Klarenbeek, A, Sadi, A, Hultberg, A, Kretz-Rommel, A, Spinelli, S, Loris, R, Cambillau, C, de Haard, H. | | Deposit date: | 2015-05-13 | | Release date: | 2016-05-04 | | Last modified: | 2016-07-06 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.
J.Biol.Chem., 291, 2016
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4O9H
 | | Structure of Interleukin-6 in complex with a Camelid Fab fragment | | Descriptor: | Heavy Chain of the Camelid Fab fragment 61H7, Interleukin-6, Light Chain of the Camelid Fab fragment 61H7 | | Authors: | Klarenbeek, A, Blanchetot, C, Schragel, G, Sadi, A.S, Ongenae, N, Hemrika, W, Wijdenes, J, Spinelli, S, Desmyter, A, Cambillau, C, Hultberg, A, Kretz-rommel, A, Dreier, T, De haard, H.J.W, Roovers, R.C. | | Deposit date: | 2014-01-02 | | Release date: | 2015-04-15 | | Last modified: | 2015-04-29 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies
To be Published
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4R90
 | | Anti CD70 Llama glama Fab 27B3 | | Descriptor: | Anti CD70 Llama glama Fab 27B3 Heavy chain, Anti CD70 Llama glama Fab 27B3 Light chain, CALCIUM ION, ... | | Authors: | Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I. | | Deposit date: | 2014-09-03 | | Release date: | 2015-06-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.746 Å) | | Cite: | Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
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4R96
 | | Structure of a Llama Glama Fab 48A2 against human cMet | | Descriptor: | Llama glama Fab 48A2 against human cMet H chain, Llama glama Fab 48A2 against human cMet L chain | | Authors: | Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I. | | Deposit date: | 2014-09-03 | | Release date: | 2015-06-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.31 Å) | | Cite: | Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
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6QRN
 | | Galectin-10 complexed with ribose | | Descriptor: | Galectin-10, beta-D-ribopyranose | | Authors: | Verstraete, K, Verschueren, K.H.G. | | Deposit date: | 2019-02-19 | | Release date: | 2019-06-05 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
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6GLX
 | | Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 4E8 | | Descriptor: | Fab 4E8 - Heavy chain, Fab 4E8 - Light chain, Galectin-10 | | Authors: | Verstraete, K, Verschueren, K, Savvides, S.N. | | Deposit date: | 2018-05-23 | | Release date: | 2019-06-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.396 Å) | | Cite: | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
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6GKU
 | | Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 6F5 | | Descriptor: | CALCIUM ION, Fab 6F5 - Heavy Chain, Fab 6F5 - Light chain, ... | | Authors: | Verstraete, K, Verschueren, K, Savvides, S.N. | | Deposit date: | 2018-05-21 | | Release date: | 2019-06-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
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6GLW
 | | Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 1D11 | | Descriptor: | ACETATE ION, Fab 1D11 - Heavy chain, Fab 1D11 - Light chain, ... | | Authors: | Verstraete, K, Verschueren, K, Savvides, S.N. | | Deposit date: | 2018-05-23 | | Release date: | 2019-06-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
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6GKT
 | | X-ray structure of a non-autocrystallizing galectin-10 variant, Gal10-Tyr69Glu | | Descriptor: | Galectin-10, HEXAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ... | | Authors: | Verstraete, K, Verschueren, K, Savvides, S.N. | | Deposit date: | 2018-05-21 | | Release date: | 2019-06-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
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6GKQ
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6GKS
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7OX1
 | | Fab 7D6: hIL-9 complex | | Descriptor: | Heavy chain (Fab 7D6), Interleukin-9, Light chain (Fab 7D6) | | Authors: | De Vos, T, Savvides, S.N. | | Deposit date: | 2021-06-22 | | Release date: | 2022-12-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Biorxiv, 2022
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7OX6
 | | Solution structure of human interleukin-9 | | Descriptor: | Interleukin-9 | | Authors: | Savvides, S.N, Tripsianes, K, De Vos, T, Papageorgiou, A, Evangelidis, T. | | Deposit date: | 2021-06-22 | | Release date: | 2022-12-28 | | Last modified: | 2023-01-11 | | Method: | SOLUTION NMR | | Cite: | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Biorxiv, 2022
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7OX4
 | | Mouse interleukin-9 in complex with Fab 35D8. | | Descriptor: | ACETATE ION, Heavy chain (Fab 35D8), Interleukin-9, ... | | Authors: | De Vos, T, Savvides, S.N. | | Deposit date: | 2021-06-22 | | Release date: | 2022-12-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Biorxiv, 2022
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7OX2
 | | Fab 6E2: hIL-9 complex | | Descriptor: | Heavy chain (Fab 6E2), Interleukin-9, Light chain (Fab 6E2), ... | | Authors: | De Vos, T, Savvides, S.N. | | Deposit date: | 2021-06-22 | | Release date: | 2022-12-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.34 Å) | | Cite: | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Biorxiv, 2022
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7OX3
 | | Fab 6D3: hIL-9 complex | | Descriptor: | Heavy chain (Fab 6D3), Interleukin-9, Light chain (Fab 6D3), ... | | Authors: | De Vos, T, Savvides, S.N. | | Deposit date: | 2021-06-22 | | Release date: | 2022-12-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Biorxiv, 2022
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7OX5
 | | hIL-9:hIL-9Ra complex | | Descriptor: | Interleukin-9, Interleukin-9 receptor, SULFATE ION | | Authors: | De Vos, T, Savvides, S.N. | | Deposit date: | 2021-06-22 | | Release date: | 2022-12-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.09 Å) | | Cite: | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Biorxiv, 2022
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