Author results

1K6W
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THE STRUCTURE OF ESCHERICHIA COLI CYTOSINE DEAMINASE
Descriptor:Cytosine Deaminase, FE (III) ION
Authors:Ireton, G.C., McDermott, G., Black, M.E., Stoddard, B.L.
Deposit date:2001-10-17
Release date:2002-02-06
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The structure of Escherichia coli cytosine deaminase.
J.Mol.Biol., 315, 2002
1K70
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THE STRUCTURE OF ESCHERICHIA COLI CYTOSINE DEAMINASE BOUND TO 4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE
Descriptor:Cytosine Deaminase, FE (III) ION, 4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE
Authors:Ireton, G.C., McDermott, G., Black, M.E., Stoddard, B.L.
Deposit date:2001-10-17
Release date:2002-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of Escherichia coli cytosine deaminase.
J.Mol.Biol., 315, 2002
1OX7
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CRYSTAL STRUCTURE OF YEAST CYTOSINE DEAMINASE APO-ENZYME: INORGANIC ZINC BOUND
Descriptor:Cytosine deaminase, ZINC ION, CALCIUM ION
Authors:Ireton, G.C., Black, M.E., Stoddard, B.L.
Deposit date:2003-04-01
Release date:2003-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:The 1.14 a crystal structure of yeast Cytosine deaminase. Evolution of nucleotide salvage enzymes and implications for genetic chemotherapy.
Structure, 11, 2003
1P6O
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THE CRYSTAL STRUCTURE OF YEAST CYTOSINE DEAMINASE BOUND TO 4(R)-HYDROXYL-3,4-DIHYDROPYRIMIDINE AT 1.14 ANGSTROMS.
Descriptor:Cytosine deaminase, ZINC ION, 4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE, ...
Authors:Ireton, G.C., Black, M.E., Stoddard, B.L.
Deposit date:2003-04-29
Release date:2003-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:The 1.14 a crystal structure of yeast Cytosine deaminase. Evolution of nucleotide salvage enzymes and implications for genetic chemotherapy.
Structure, 11, 2003
1R9X
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BACTERIAL CYTOSINE DEAMINASE D314G MUTANT.
Descriptor:Cytosine deaminase, FE (III) ION, MAGNESIUM ION, ...
Authors:Mahan, S.D., Ireton, G.C., Stoddard, B.L., Black, M.E.
Deposit date:2003-10-31
Release date:2004-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
1R9Y
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BACTERIAL CYTOSINE DEAMINASE D314A MUTANT.
Descriptor:Cytosine deaminase, FE (III) ION, MAGNESIUM ION, ...
Authors:Mahan, S.D., Ireton, G.C., Stoddard, B.L., Black, M.E.
Deposit date:2003-10-31
Release date:2004-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
1R9Z
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BACTERIAL CYTOSINE DEAMINASE D314S MUTANT.
Descriptor:Cytosine deaminase, FE (III) ION, MAGNESIUM ION, ...
Authors:Mahan, S.D., Ireton, G.C., Stoddard, B.L., Black, M.E.
Deposit date:2003-10-31
Release date:2004-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
1RA0
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BACTERIAL CYTOSINE DEAMINASE D314G MUTANT BOUND TO 5-FLUORO-4-(S)-HYDROXY-3,4-DIHYDROPYRIMIDINE.
Descriptor:Cytosine deaminase, FE (III) ION, (4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE
Authors:Mahan, S.D., Ireton, G.C., Stoddard, B.L., Black, M.E.
Deposit date:2003-10-31
Release date:2004-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
1RA5
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BACTERIAL CYTOSINE DEAMINASE D314A MUTANT BOUND TO 5-FLUORO-4-(S)-HYDROXYL-3,4-DIHYDROPYRIMIDINE.
Descriptor:Cytosine deaminase, FE (III) ION, (4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE, ...
Authors:Mahan, S.D., Ireton, G.C., Stoddard, B.L., Black, M.E.
Deposit date:2003-10-31
Release date:2004-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
1RAK
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BACTERIAL CYTOSINE DEAMINASE D314S MUTANT BOUND TO 5-FLUORO-4-(S)-HYDROXYL-3,4-DIHYDROPYRIMIDINE.
Descriptor:Cytosine deaminase, FE (III) ION, (4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE, ...
Authors:Mahan, S.D., Ireton, G.C., Stoddard, B.L., Black, M.E.
Deposit date:2003-10-31
Release date:2004-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
1YSB
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YEAST CYTOSINE DEAMINASE TRIPLE MUTANT
Descriptor:Cytosine deaminase, ZINC ION, CALCIUM ION
Authors:Korkegian, A., Black, M.E., Baker, D., Stoddard, B.L.
Deposit date:2005-02-08
Release date:2005-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Computational thermostabilization of an enzyme.
Science, 308, 2005
1YSD
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YEAST CYTOSINE DEAMINASE DOUBLE MUTANT
Descriptor:Cytosine deaminase, ZINC ION, CALCIUM ION
Authors:Korkegian, A., Black, M.E., Baker, D., Stoddard, B.L.
Deposit date:2005-02-08
Release date:2005-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computational thermostabilization of an enzyme.
Science, 308, 2005
2O3K
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YEAST CYTOSINE DEAMINASE D92E TRIPLE MUTANT BOUND TO TRANSITION STATE ANALOGUE HPY
Descriptor:Cytosine deaminase, ZINC ION, 4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE, ...
Authors:Korkegian, A.M., Stoddard, B.L.
Deposit date:2006-12-01
Release date:2007-10-16
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY
To be Published
3G77
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BACTERIAL CYTOSINE DEAMINASE V152A/F316C/D317G MUTANT
Descriptor:Cytosine deaminase, FE (III) ION
Authors:Stoddard, B., Zhao, L.
Deposit date:2009-02-09
Release date:2009-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bacterial cytosine deaminase mutants created by molecular engineering show improved 5-fluorocytosine-mediated cell killing in vitro and in vivo.
Cancer Res., 69, 2009