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1MI7
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BU of 1mi7 by Molmil
Crystal Structure of Domain Swapped trp Aporepressor in 30%(v/v) Isopropanol
Descriptor: ISOPROPYL ALCOHOL, Trp operon repressor
Authors:Lawson, C.L, Benoff, B, Berger, T, Berman, H.M, Carey, J.
Deposit date:2002-08-22
Release date:2003-09-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:E. coli trp repressor forms a domain-swapped array in aqueous alcohol.
Structure, 12, 2004
3L2P
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BU of 3l2p by Molmil
Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States
Descriptor: 5'-D(*GP*CP*CP*AP*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*CP*CP*G)-3', 5'-D(*GP*TP*CP*GP*GP*AP*CP*TP*G)-3', 5'-D(P*CP*GP*GP*GP*AP*TP*GP*CP*GP*TP*C)-3', ...
Authors:Cotner-Gohara, E.A, Kim, I.K, Hammel, M, Tainer, J.A, Tomkinson, A, Ellenberger, T.
Deposit date:2009-12-15
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching between Two DNA-Bound States.
Biochemistry, 49, 2010
2A1J
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BU of 2a1j by Molmil
Crystal Structure of the Complex between the C-Terminal Domains of Human XPF and ERCC1
Descriptor: DNA excision repair protein ERCC-1, DNA repair endonuclease XPF, MERCURY (II) ION
Authors:Tsodikov, O.V, Enzlin, J.H, Scharer, O.D, Ellenberger, T.
Deposit date:2005-06-20
Release date:2005-08-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1ZYQ
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BU of 1zyq by Molmil
T7 DNA polymerase in complex with 8oG and incoming ddATP
Descriptor: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*CP*CP*(8OG)P*CP*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*TP*CP*G)-3', 5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DDG))-3', ...
Authors:Brieba, L.G, Kokoska, R.J, Bebenek, K, Kunkel, T.A, Ellenberger, T.
Deposit date:2005-06-10
Release date:2005-11-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A lysine residue in the fingers subdomain of t7 DNA polymerase modulates the miscoding potential of 8-oxo-7,8-dihydroguanosine.
Structure, 13, 2005
2A1I
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BU of 2a1i by Molmil
Crystal Structure of the Central Domain of Human ERCC1
Descriptor: DNA excision repair protein ERCC-1, MERCURY (II) ION
Authors:Tsodikov, O.V, Enzlin, J.H, Scharer, O.D, Ellenberger, T.
Deposit date:2005-06-20
Release date:2005-08-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1NUI
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BU of 1nui by Molmil
Crystal Structure of the primase fragment of Bacteriophage T7 primase-helicase protein
Descriptor: DNA primase/helicase, MAGNESIUM ION, ZINC ION
Authors:Kato, M, Ito, T, Wagner, G, Richardson, C.C, Ellenberger, T.
Deposit date:2003-01-31
Release date:2003-05-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Modular Architecture of the Bacteriophage T7 Primase Couples RNA primer Synthesis to DNA Synthesis
Mol.Cell, 11, 2003
1AE9
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BU of 1ae9 by Molmil
STRUCTURE OF THE LAMBDA INTEGRASE CATALYTIC CORE
Descriptor: LAMBDA INTEGRASE
Authors:Kwon, H.J, Tirumalai, R, Landy, A, Ellenberger, T.
Deposit date:1997-03-06
Release date:1997-11-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Flexibility in DNA recombination: structure of the lambda integrase catalytic core.
Science, 276, 1997
6O9Y
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BU of 6o9y by Molmil
Structure of human PARG complexed with JA2-8
Descriptor: 7-[(2S)-2-hydroxy-3-(morpholin-4-yl)propyl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OA3
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BU of 6oa3 by Molmil
Structure of human PARG complexed with JA2131
Descriptor: (8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OA0
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BU of 6oa0 by Molmil
Structure of human PARG complexed with JA2-9
Descriptor: 4-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)butanoic acid, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
1BNK
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BU of 1bnk by Molmil
HUMAN 3-METHYLADENINE DNA GLYCOSYLASE COMPLEXED TO DNA
Descriptor: DNA (5'-D(*GP*AP*CP*AP*TP*GP*YRRP*TP*TP*GP*CP*CP*T)-3'), DNA (5'-D(*GP*GP*CP*AP*AP*TP*CP*AP*TP*GP*TP*CP*A)-3'), PROTEIN (3-METHYLADENINE DNA GLYCOSYLASE)
Authors:Lau, A.Y, Schaerer, O.D, Samson, L, Verdine, G.L, Ellenberger, T.
Deposit date:1998-07-29
Release date:1998-10-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision.
Cell(Cambridge,Mass.), 95, 1998
6O9X
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BU of 6o9x by Molmil
Structure of human PARG complexed with JA2-4
Descriptor: 1,3-dimethyl-8-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,9-tetrahydro-2H-purin-2-one, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OA1
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BU of 6oa1 by Molmil
Structure of human PARG complexed with JA2120
Descriptor: 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-3,7-dihydro-1H-purine-2,6-dione, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
2ONT
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BU of 2ont by Molmil
A swapped dimer of the HIV-1 capsid C-terminal domain
Descriptor: Capsid protein p24
Authors:Ivanov, D, Tsodikov, O.V, Kasanov, J, Ellenberger, T, Wagner, G, Collins, T.
Deposit date:2007-01-24
Release date:2007-02-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Domain-swapped dimerization of the HIV-1 capsid C-terminal domain
Proc.Natl.Acad.Sci.Usa, 104, 2007
6P7E
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BU of 6p7e by Molmil
Structure of T7 DNA Polymerase Bound to a Primer/Template DNA and a Peptide that Mimics the C-terminal Tail of the Primase-Helicase
Descriptor: ASP-THR-ASP-PHE peptide, DNA (25-MER), DNA (5'-D(P*GP*GP*CP*AP*GP*GP*TP*GP*GP*TP*CP*TP*TP*GP*CP*CP*GP*GP*TP*GP*A)-3'), ...
Authors:Foster, B.M, Rosenberg, D, Salvo, H, Stephens, K.L, Bintz, B.J, Hammel, M, Ellenberger, T, Gainey, M.D, Wallen, J.R.
Deposit date:2019-06-05
Release date:2020-03-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.001 Å)
Cite:Combined Solution and Crystal Methods Reveal the Electrostatic Tethers That Provide a Flexible Platform for Replication Activities in the Bacteriophage T7 Replisome.
Biochemistry, 58, 2019
3GNU
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BU of 3gnu by Molmil
Toxin fold as basis for microbial attack and plant defense
Descriptor: 25 kDa protein elicitor, CHLORIDE ION, GUANIDINE
Authors:Ottmann, C, Luberacki, B, Kuefner, I, Koch, W, Brunner, F, Weyand, M, Mattinen, L, Pirhonen, M, Anderluh, G, Seitz, H.U, Nuernberger, T, Oecking, C.
Deposit date:2009-03-18
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A common toxin fold mediates microbial attack and plant defense
Proc.Natl.Acad.Sci.USA, 106, 2009
3GNZ
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BU of 3gnz by Molmil
Toxin fold for microbial attack and plant defense
Descriptor: 25 kDa protein elicitor, MAGNESIUM ION
Authors:Ottmann, C, Luberacki, B, Kuefner, I, Koch, W, Brunner, F, Weyand, M, Mattinen, L, Pirhonen, M, Anderluh, G, Seitz, H.U, Nuernberger, T, Oecking, C.
Deposit date:2009-03-18
Release date:2009-06-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:A common toxin fold mediates microbial attack and plant defense
Proc.Natl.Acad.Sci.USA, 106, 2009
6WH1
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BU of 6wh1 by Molmil
Structure of the complex of human DNA ligase III-alpha and XRCC1 BRCT domains
Descriptor: DNA ligase 3 alpha, X-ray repair cross complementing protein 1 variant
Authors:Pourfarjam, Y, Ellenberger, T, Tainer, J.A, Tomkinson, A.E, Kim, I.K.
Deposit date:2020-04-07
Release date:2020-12-02
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III alpha within a flexible DNA repair complex.
Nucleic Acids Res., 49, 2021
6WH2
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BU of 6wh2 by Molmil
Structure of the C-terminal BRCT domain of human XRCC1
Descriptor: X-ray repair cross complementing protein 1 variant
Authors:Pourfarjam, Y, Ellenberger, T, Tainer, J.A, Tomkinson, A.E, Kim, I.K.
Deposit date:2020-04-07
Release date:2020-12-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.414 Å)
Cite:An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III alpha within a flexible DNA repair complex.
Nucleic Acids Res., 49, 2021
1Z1B
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BU of 1z1b by Molmil
Crystal structure of a lambda integrase dimer bound to a COC' core site
Descriptor: 26-MER DNA, 29-MER DNA, 5'-D(*CP*T*CP*GP*TP*TP*CP*AP*GP*CP*TP*TP*TP*TP*TP*T)-3', ...
Authors:Biswas, T, Aihara, H, Radman-Livaja, M, Filman, D, Landy, A, Ellenberger, T.
Deposit date:2005-03-03
Release date:2005-06-28
Last modified:2022-04-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:A structural basis for allosteric control of DNA recombination by lambda integrase.
Nature, 435, 2005
1Z1G
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BU of 1z1g by Molmil
Crystal structure of a lambda integrase tetramer bound to a Holliday junction
Descriptor: 25-MER, 29-MER, 5'-D(*AP*CP*AP*GP*GP*TP*CP*AP*CP*TP*AP*TP*CP*AP*GP*TP*CP*AP*AP*AP*AP*TP*AP*CP*C)-3', ...
Authors:Biswas, T, Aihara, H, Radman-Livaja, M, Filman, D, Landy, A, Ellenberger, T.
Deposit date:2005-03-03
Release date:2005-06-28
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:A structural basis for allosteric control of DNA recombination by lambda integrase.
Nature, 435, 2005
1Z19
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BU of 1z19 by Molmil
Crystal structure of a lambda integrase(75-356) dimer bound to a COC' core site
Descriptor: 33-MER, 5'-D(*CP*TP*CP*GP*TP*TP*CP*AP*GP*CP*TP*TP*TP*TP*TP*T)-3', 5'-D(P*TP*TP*TP*AP*TP*AP*CP*TP*AP*AP*GP*TP*TP*GP*GP*CP*AP*TP*TP*A)-3', ...
Authors:Biswas, T, Aihara, H, Radman-Livaja, M, Filman, D, Landy, A, Ellenberger, T.
Deposit date:2005-03-03
Release date:2005-06-28
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A structural basis for allosteric control of DNA recombination by lambda integrase.
Nature, 435, 2005
5KVH
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BU of 5kvh by Molmil
Crystal structure of human apoptosis-inducing factor with W196A mutation
Descriptor: Apoptosis-inducing factor 1, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Brosey, C.A, Nix, J, Ellenberger, T, Tainer, J.A.
Deposit date:2016-07-14
Release date:2016-11-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.273 Å)
Cite:Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor.
Structure, 24, 2016
5KVI
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BU of 5kvi by Molmil
Crystal structure of monomeric human apoptosis-inducing factor with E413A/R422A/R430A mutations
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Apoptosis-inducing factor 1, mitochondrial, ...
Authors:Brosey, C.A, Nix, J, Ellenberger, T, Tainer, J.A.
Deposit date:2016-07-14
Release date:2016-11-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.995 Å)
Cite:Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor.
Structure, 24, 2016
5IKN
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BU of 5ikn by Molmil
Crystal Structure of the T7 Replisome in the Absence of DNA
Descriptor: DNA primase/helicase, DNA-directed DNA polymerase, Thioredoxin-1
Authors:Wallen, J.R, Ellenberger, T.
Deposit date:2016-03-03
Release date:2016-12-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (4.802 Å)
Cite:Hybrid Methods Reveal Multiple Flexibly Linked DNA Polymerases within the Bacteriophage T7 Replisome.
Structure, 25, 2017

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