Author results

4J30
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STRUCTURE OF THE EFFECTOR - IMMUNITY SYSTEM TAE4 / TAI4 FROM SALMONELLA TYPHIMURIUM, SELENOMETHIONINE VARIANT
分子名称:Putative cytoplasmic protein, Putative periplasmic protein, CITRATE ANION, ...
著者Benz, J., Reinstein, J., Meinhart, A.
登録日2013-02-05
公開日2013-05-22
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Insights into the Effector - Immunity System Tae4/Tai4 from Salmonella typhimurium.
Plos One, 8, 2013
4J32
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STRUCTURE OF THE EFFECTOR - IMMUNITY SYSTEM TAE4 / TAI4 FROM SALMONELLA TYPHIMURIUM
分子名称:Putative cytoplasmic protein, Putative periplasmic protein, CITRATE ANION, ...
著者Benz, J., Reinstein, J., Meinhart, A.
登録日2013-02-05
公開日2013-05-22
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Insights into the Effector - Immunity System Tae4/Tai4 from Salmonella typhimurium.
Plos One, 8, 2013
6ELE
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FAB FRAGMENT. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN ANTIBODY DRUG DISCOVERY
分子名称:fAB heavy chain, fAB light chain, 1,2-ETHANEDIOL, ...
著者Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G.
登録日2017-09-28
公開日2017-11-08
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
To Be Published
6ELJ
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FAB FRAGMENT. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN ANTIBODY DRUG DISCOVERY
分子名称:fAB heavy chain, fAB light chain
著者Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G.
登録日2017-09-29
公開日2017-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
To Be Published
6ELL
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FAB FRAGMENT. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN ANTIBODY DRUG DISCOVERY
分子名称:fAB heavy chain, fAB light chain
著者Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G.
登録日2017-09-29
公開日2017-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
To Be Published
6EMJ
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FAB FRAGMENT. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN ANTIBODY DRUG DISCOVERY
分子名称:fAB heavy chain, fAb light chain, SODIUM ION
著者Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G.
登録日2017-10-02
公開日2017-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
To Be Published
1QDE
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CRYSTAL STRUCTURE OF THE ATPASE DOMAIN OF TRANSLATION INITIATION FACTOR 4A FROM SACCHAROMYCES CEREVISIAE-THE PROTOTYPE OF THE DEAD BOX PROTEIN FAMILY
分子名称:TRANSLATION INITIATION FACTOR 4A, SULFATE ION
著者Benz, J., Trachsel, H., Baumann, U.
登録日1999-05-20
公開日2000-05-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family.
Structure Fold.Des., 7, 1999
4FGD
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STRUCTURE OF THE EFFECTOR PROTEIN TSE1 FROM PSEUDOMONAS AERUGINOSA, SELENOMETHIONINE VARIANT
分子名称:Tse1, THIOCYANATE ION, CHLORIDE ION
著者Benz, J., Sendlmeier, C., Barends, T.R.M., Meinhart, A.
登録日2012-06-04
公開日2012-06-20
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Insights into the Effector - Immunity System Tse1/Tsi1 from Pseudomonas aeruginosa.
Plos One, 7, 2012
4FGE
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STRUCTURE OF THE EFFECTOR PROTEIN TSE1 FROM PSEUDOMONAS AERUGINOSA
分子名称:Tse1, CHLORIDE ION, THIOCYANATE ION, ...
著者Benz, J., Sendlmeier, C., Barends, T.R.M., Meinhart, A.
登録日2012-06-04
公開日2012-06-20
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Insights into the Effector - Immunity System Tse1/Tsi1 from Pseudomonas aeruginosa.
Plos One, 7, 2012
4FGI
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STRUCTURE OF THE EFFECTOR - IMMUNITY SYSTEM TSE1 / TSI1 FROM PSEUDOMONAS AERUGINOSA
分子名称:Tse1, Tsi1
著者Benz, J., Sendlmeier, C., Barends, T.R.M., Meinhart, A.
登録日2012-06-04
公開日2012-06-20
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural Insights into the Effector - Immunity System Tse1/Tsi1 from Pseudomonas aeruginosa.
Plos One, 7, 2012
2FVJ
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A NOVEL ANTI-ADIPOGENIC PARTIAL AGONIST OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA (PPARG) RECRUITS PPARG-COACTIVATOR-1 ALPHA (PGC1A) BUT POTENTIATES INSULIN SIGNALING IN VITRO
分子名称:Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-4-{[4-(2-METHOXYPHENYL)PIPERIDIN-1-YL]METHYL}ISOQUINOLINE, ...
著者Benz, J., Burgermeister, E., Flament, A., Schnoebelen, A., Stihle, M., Gsell, B., Rufer, A., Ruf, A., Kuhn, B., Maerki, H.P., Mizrahi, J., Sebokova, E., Niesor, E., Meyer, M.
登録日2006-01-31
公開日2006-05-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro
Mol.Endocrinol., 20, 2006
5CSZ
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CRYSTAL STRUCTURE OF GANTENERUMAB FAB FRAGMENT IN COMPLEX WITH ABETA 1-11
分子名称:GANTENERUMAB FAB FRAGMENT HEAVY CHAIN, GANTENERUMAB FAB FRAGMENT LIGHT CHAIN, Amyloid beta A4 protein, ...
著者Benz, J., Burger, D., Loetscher, H.R., Bohrmann, B.
登録日2015-07-23
公開日2015-08-12
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-Beta binding and elicits cell-mediated removal of human amyloid-Beta.
J. Alzheimers Dis., 28, 2012
3FEI
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DESIGN AND BIOLOGICAL EVALUATION OF NOVEL, BALANCED DUAL PPARA/G AGONISTS
分子名称:Peroxisome proliferator-activated receptor alpha, Peptide motif 5 of Nuclear receptor coactivator 1, (2S)-3-(4-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylphenyl)-2-ethoxypropanoic acid
著者Benz, J., Grether, U., Gsell, B., Binggeli, A., Hilpert, H., Maerki, H.P., Mohr, P., Ruf, A., Stihle, M., Schlatter, D.
登録日2008-11-30
公開日2009-10-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists
Chemmedchem, 4, 2009
3FEJ
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DESIGN AND BIOLOGICAL EVALUATION OF NOVEL, BALANCED DUAL PPARA/G AGONISTS
分子名称:Peroxisome proliferator-activated receptor gamma, peptide motif 3 of Nuclear receptor coactivator 1, (2S)-3-(4-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylphenyl)-2-ethoxypropanoic acid
著者Benz, J., Grether, U., Gsell, B., Binggeli, A., Hilpert, H., Kuhn, B., Maerki, H.P., Mohr, P., Ruf, A., Stihle, M.
登録日2008-11-30
公開日2009-10-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists
Chemmedchem, 4, 2009
3G8I
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ALEGLITAZAR, A NEW, POTENT, AND BALANCED PPAR ALPHA/GAMMA AGONIST FOR THE TREATMENT OF TYPE II DIABETES
分子名称:Peroxisome proliferator-activated receptor alpha, Nuclear receptor coactivator 1, (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid
著者Benz, J., Bernardeau, A., Binggeli, A., Blum, D., Boehringer, M., Grether, U., Hilpert, H., Kuhn, B., Maerki, H.P., Meyer, M., Puentener, K., Raab, S., Ruf, A., Schlatter, D., Gsell, B., Stihle, M., Mohr, P.
登録日2009-02-12
公開日2009-06-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.
Bioorg.Med.Chem.Lett., 19, 2009
4LIQ
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STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CSF-1 RECEPTOR IN COMPLEX WITH THE FAB FRAGMENT OF RG7155
分子名称:Macrophage colony-stimulating factor 1 receptor, Fab fragment RG7155 heavy chain, Fab fragment RG7155 light chain, ...
著者Benz, J., Gorr, I.H., Hertenberger, H., Ries, C.H.
登録日2013-07-03
公開日2014-06-18
最終更新日2014-12-24
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy
Cancer Cell, 25, 2014
5DMG
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X-RAY STRUCTURE OF THE FAB FRAGMENT OF THE ANTI TAU ANTIBODY RB86 IN COMPLEX WITH THE PHOSPHORYLATED TAU PEPTIDE (416-430)
分子名称:RB86 antibody Fab fragment heavy chain, RB86 antibody Fab fragment light chain, Microtubule-associated protein
著者Benz, J., Lorenz, S., Georges, G., Jochner, A., Goepfert, U., Grueninger, F., Bujotzek, A.
登録日2015-09-08
公開日2015-12-16
最終更新日2016-03-02
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献VH-VL orientation prediction for antibody humanization candidate selection: A case study.
Mabs, 8, 2016
1CJA
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ACTIN-FRAGMIN KINASE, CATALYTIC DOMAIN FROM PHYSARUM POLYCEPHALUM
分子名称:PROTEIN (ACTIN-FRAGMIN KINASE), ADENOSINE MONOPHOSPHATE
著者Steinbacher, S., Hof, P., Eichinger, L., Schleicher, M., Gettemans, J., Vandekerckhove, J., Huber, R., Benz, J.
登録日1999-04-08
公開日1999-06-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain.
EMBO J., 18, 1999
3ZKX
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TERNARY BACE2 XAPERONE COMPLEX
分子名称:BETA-SECRETASE 2, XA4813, XA4815, ...
著者Kuglstatter, A., Banner, D.W., Benz, J., Bertschinger, J., Burger, D., Cuppuleri, S., Debulpaep, M., Gast, A., Grabulovski, D., Gsell, B., Hilpert, H., Huber, W., Kusznir, E., Laeremans, T., Matile, H., Rufer, A., Schlatter, D., Steyeart, J., Stihle, M., Thoma, R., Weber, M., Ruf, A.
登録日2013-01-25
公開日2013-05-29
最終更新日2013-06-05
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Mapping the Conformational Space Accessible to Bace2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones
Acta Crystallogr.,Sect.D, 69, 2013
1W6J
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STRUCTURE OF HUMAN OSC IN COMPLEX WITH RO 48-8071
分子名称:LANOSTEROL SYNTHASE, [4-({6-[ALLYL(METHYL)AMINO]HEXYL}OXY)-2-FLUOROPHENYL](4-BROMOPHENYL)METHANONE, B-OCTYLGLUCOSIDE, ...
著者Thoma, R., Schulz-Gasch, T., D'Arcy, B., Benz, J., Aebi, J., Dehmlow, H., Hennig, M., Ruf, A.
登録日2004-08-18
公開日2004-10-29
最終更新日2013-11-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase
Nature, 432, 2004
1W6K
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STRUCTURE OF HUMAN OSC IN COMPLEX WITH LANOSTEROL
分子名称:LANOSTEROL SYNTHASE, B-OCTYLGLUCOSIDE, LANOSTEROL
著者Thoma, R., Schulz-Gasch, T., D'Arcy, B., Benz, J., Aebi, J., Dehmlow, H., Hennig, M., Ruf, A.
登録日2004-08-19
公開日2004-10-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase
Nature, 432, 2004
2XBV
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FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR
分子名称:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, (3R,4R)-1-(2,2-DIFLUORO-ETHYL)-PYRROLIDINE-3,4-DICARBOXYLIC ACID 3-[(5-CHLORO-PYRIDIN-2-YL)-AMIDE]-4-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYL]-AMIDE}, ...
著者Banner, D.W., Benz, J., Schlatter, D., Anselm, L., Haap, W.
登録日2010-04-15
公開日2010-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-Difluoro-Ethyl)-Pyrrolidine-3,4-Dicarboxylic Acid 3-[(5-Chloro-Pyridin-2-Yl)-Amide] 4-{[2-Fluoro-4-(2-Oxo-2H-Pyridin-1-Yl)-Phenyl]-Amide} as a Clinical Candidate.
Bioorg.Med.Chem., 20, 2010
2XBW
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FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR
分子名称:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, (3R,4R)-1-SULFAMOYL-PYRROLIDINE-3,4-DICARBOXYLIC ACID 3-[(4-CHLORO-PHENYL)-AMIDE] 4-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYL]-AMIDE}, ...
著者Banner, D.W., Benz, J., Schlatter, D., Thomi, S., Haap, W.
登録日2010-04-15
公開日2010-08-04
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-Difluoro-Ethyl)-Pyrrolidine-3,4-Dicarboxylic Acid 3-[(5-Chloro-Pyridin-2-Yl)-Amide] 4-{[2-Fluoro-4-(2-Oxo-2H-Pyridin-1-Yl)-Phenyl]-Amide} as a Clinical Candidate.
Bioorg.Med.Chem., 20, 2010
2XBX
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FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR
分子名称:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, (3R,4R)-1-METHANESULFONYL-PYRROLIDINE-3,4-DICARBOXYLIC ACID 3-[(4-CHLORO-PHENYL)-AMIDE] 4-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYL]-AMIDE}, ...
著者Banner, D.W., Benz, J., Schlatter, D., Haap, W.
登録日2010-04-15
公開日2010-08-04
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-Difluoro-Ethyl)-Pyrrolidine-3,4-Dicarboxylic Acid 3-[(5-Chloro-Pyridin-2-Yl)-Amide] 4-{[2-Fluoro-4-(2-Oxo-2H-Pyridin-1-Yl)-Phenyl]-Amide} as a Clinical Candidate.
Bioorg.Med.Chem., 20, 2010
2XBY
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FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR
分子名称:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, (3R,4R)-1-METHYLCARBAMOYLMETHYL-PYRROLIDINE-3,4-DICARBOXYLIC ACID 3-[(4-CHLORO-PHENYL)-AMIDE] 4-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYL]-AMIDE}, ...
著者Banner, D.W., Benz, J., Schlatter, D., Thomi, S., Haap, W.
登録日2010-04-15
公開日2010-08-04
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-Difluoro-Ethyl)-Pyrrolidine-3,4-Dicarboxylic Acid 3-[(5-Chloro-Pyridin-2-Yl)-Amide] 4-{[2-Fluoro-4-(2-Oxo-2H-Pyridin-1-Yl)-Phenyl]-Amide} as a Clinical Candidate.
Bioorg.Med.Chem., 20, 2010