5FN2 | | CRYO-EM STRUCTURE OF GAMMA SECRETASE IN COMPLEX WITH A DRUG DAPT | | Descriptor: | NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2 | | Authors: | Bai, X.C., Rajendra, E., Yang, G.H., Shi, Y.G., Scheres, S.H.W. | | Deposit date: | 2015-11-10 | | Release date: | 2015-12-16 | | Last modified: | 2016-12-21 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
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5FN3 | | CRYO-EM STRUCTURE OF GAMMA SECRETASE IN CLASS 1 OF THE APO- STATE ENSEMBLE | | Descriptor: | NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2, POLY ALA CHAIN | | Authors: | Bai, X.C., Rajendra, E., Yang, G.H., Shi, Y.G., Scheres, S.H.W. | | Deposit date: | 2015-11-10 | | Release date: | 2015-12-16 | | Last modified: | 2016-12-21 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
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5FN4 | | CRYO-EM STRUCTURE OF GAMMA SECRETASE IN CLASS 2 OF THE APO- STATE ENSEMBLE | | Descriptor: | NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2, POLY ALA CHAIN | | Authors: | Bai, X.C., Rajendra, E., Yang, G.H., Shi, Y.G., Scheres, S.H.W. | | Deposit date: | 2015-11-10 | | Release date: | 2015-12-16 | | Last modified: | 2016-12-21 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
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5FN5 | | CRYO-EM STRUCTURE OF GAMMA SECRETASE IN CLASS 3 OF THE APO- STATE ENSEMBLE | | Descriptor: | NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2 | | Authors: | Bai, X.C., Rajendra, E., Yang, G.H., Shi, Y.G., Scheres, S.H.W. | | Deposit date: | 2015-11-10 | | Release date: | 2015-12-16 | | Last modified: | 2016-12-21 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
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5GKY | | STRUCTURE OF RYR1 IN A CLOSED STATE (C1 CONFORMER) | | Descriptor: | RyR1, FKBP12 | | Authors: | Bai, X.C., Yan, Z., Wu, J.P., Yan, N. | | Deposit date: | 2016-07-07 | | Release date: | 2016-08-24 | | Last modified: | 2016-09-14 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Cell Res., 26, 2016
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5GKZ | | STRUCTURE OF RYR1 IN A CLOSED STATE (C3 CONFORMER) | | Descriptor: | Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A (E.C.5.2.1.8) | | Authors: | Bai, X.C., Yan, Z., Wu, J.P., Yan, N. | | Deposit date: | 2016-07-07 | | Release date: | 2016-08-24 | | Last modified: | 2016-09-14 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Cell Res., 26, 2016
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5GL0 | | STRUCTURE OF RYR1 IN A CLOSED STATE (C4 CONFORMER) | | Descriptor: | Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A (E.C.5.2.1.8) | | Authors: | Bai, X.C., Yan, Z., Wu, J.P., Yan, N. | | Deposit date: | 2016-07-07 | | Release date: | 2016-08-24 | | Last modified: | 2016-09-14 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Cell Res., 26, 2016
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5GL1 | | STRUCTURE OF RYR1 IN AN OPEN STATE | | Descriptor: | Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A (E.C.5.2.1.8) | | Authors: | Bai, X.C., Yan, Z., Wu, J.P., Yan, N. | | Deposit date: | 2016-07-07 | | Release date: | 2016-08-24 | | Last modified: | 2016-09-14 | | Method: | ELECTRON MICROSCOPY (5.7 Å) | | Cite: | The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Cell Res., 26, 2016
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5GAM | | FOOT REGION OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP | | Descriptor: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, Small nuclear ribonucleoprotein-associated protein B, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, Unknown polypeptide, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2/RNA Complex | | Authors: | Nguyen, T.H.D., Galej, W.P., Bai, X.C., Oubridge, C., Scheres, S.H.W., Newman, A.J., Nagai, K. | | Deposit date: | 2015-12-15 | | Release date: | 2016-02-03 | | Last modified: | 2016-10-12 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution
Nature, 530, 2016
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5GAN | | THE OVERALL STRUCTURE OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP AT 3.7 ANGSTROM | | Descriptor: | Pre-mRNA-splicing factor 8, U4/U6 small nuclear ribonucleoprotein PRP4, Pre-mRNA-splicing factor 6, Spliceosomal protein DIB1, Pre-mRNA-processing factor 31, U4/U6 small nuclear ribonucleoprotein PRP3, Pre-mRNA-splicing helicase BRR2, Unknown protein, Small nuclear ribonucleoprotein-associated protein B, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, Snu66, 13 kDa ribonucleoprotein-associated protein, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, U6 snRNA-associated Sm-like protein LSm4, U6 snRNA-associated Sm-like protein LSm5, U6 snRNA-associated Sm-like protein LSm6, U6 snRNA-associated Sm-like protein LSm7, U6 snRNA-associated Sm-like protein LSm8, Pre-mRNA-splicing factor SNU114/RNA Complex | | Authors: | Nguyen, T.H.D., Galej, W.P., Bai, X.C., Oubridge, C., Scheres, S.H.W., Newman, A.J., Nagai, K. | | Deposit date: | 2015-12-15 | | Release date: | 2016-01-27 | | Last modified: | 2016-05-25 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
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5GAO | | HEAD REGION OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP | | Descriptor: | Small nuclear ribonucleoprotein-associated protein B, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, Snu66, Pre-mRNA-splicing helicase BRR2, Pre-mRNA-splicing factor 8/RNA Complex | | Authors: | Nguyen, T.H.D., Galej, W.P., Bai, X.C., Oubridge, C., Scheres, S.H.W., Newman, A.J., Nagai, K. | | Deposit date: | 2015-12-15 | | Release date: | 2016-01-27 | | Last modified: | 2016-03-02 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
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3J6B | | STRUCTURE OF THE YEAST MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT | | Descriptor: | PROTEIN/RNA Complex | | Authors: | Amunts, A., Brown, A., Bai, X.C., Llacer, J.L., Hussain, T., Emsley, P., Long, F., Murshudov, G., Scheres, S.H.W., Ramakrishnan, V. | | Deposit date: | 2014-01-22 | | Release date: | 2014-04-09 | | Last modified: | 2014-12-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of the yeast mitochondrial large ribosomal subunit.
Science, 343, 2014
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3J79 | | CRYO-EM STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTI-PROTOZOAN DRUG EMETINE, LARGE SUBUNIT | | Descriptor: | PROTEIN/RNA Complex | | Authors: | Wong, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W. | | Deposit date: | 2014-06-02 | | Release date: | 2014-07-16 | | Last modified: | 2015-06-03 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
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3J7A | | CRYO-EM STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTI-PROTOZOAN DRUG EMETINE, SMALL SUBUNIT | | Descriptor: | PROTEIN/RNA Complex | | Authors: | Wong, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W. | | Deposit date: | 2014-06-03 | | Release date: | 2014-07-16 | | Last modified: | 2015-06-03 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
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3J7Y | | STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM HUMAN MITOCHONDRIA | | Descriptor: | PROTEIN/RNA Complex | | Authors: | Brown, A., Amunts, A., Bai, X.C., Sugimoto, Y., Edwards, P.C., Murshudov, G., Scheres, S.H.W., Ramakrishnan, V. | | Deposit date: | 2014-08-26 | | Release date: | 2014-10-15 | | Last modified: | 2014-11-19 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure of the large ribosomal subunit from human mitochondria.
Science, 346, 2014
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4V8Y | | CRYO-EM RECONSTRUCTION OF THE 80S-EIF5B-MET-ITRNAMET EUKARYOTIC TRANSLATION INITIATION COMPLEX | | Descriptor: | 80S Ribosome | | Authors: | Fernandez, I.S., Bai, X.C., Hussain, T., Kelley, A.C., Lorsch, J.R., Ramakrishnan, V., Scheres, S.H.W. | | Deposit date: | 2013-07-20 | | Release date: | 2014-07-09 | | Last modified: | 2014-12-10 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Molecular Architecture of a Eukaryotic Translational Initiation Complex.
Science, 342, 2013
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4V8Z | | CRYO-EM RECONSTRUCTION OF THE 80S-EIF5B-MET-ITRNAMET EUKARYOTIC TRANSLATION INITIATION COMPLEX | | Descriptor: | 80S Ribosome | | Authors: | Fernandez, I.S., Bai, X.C., Hussain, T., Kelley, A.C., Lorsch, J.R., Ramakrishnan, V., Scheres, S.H.W. | | Deposit date: | 2013-07-20 | | Release date: | 2014-07-09 | | Last modified: | 2014-12-10 | | Method: | ELECTRON MICROSCOPY (6.6 Å) | | Cite: | Molecular Architecture of a Eukaryotic Translational Initiation Complex.
Science, 342, 2013
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5G5P | | STRUCTURE OF THE SACCHAROMYCES CEREVISIAE TREX-2 COMPLEX | | Descriptor: | NUCLEAR MRNA EXPORT PROTEIN SAC3, NUCLEAR MRNA EXPORT PROTEIN THP1, 26S PROTEASOME COMPLEX SUBUNIT SEM1 | | Authors: | Aibara, S., Bai, X.C., Stewart, M. | | Deposit date: | 2016-05-26 | | Release date: | 2016-11-23 | | Last modified: | 2016-12-14 | | Method: | ELECTRON MICROSCOPY (5.3 Å) | | Cite: | The Sac3 Tpr-Like Region in the Saccharomyces Cerevisiae Trex-2 Complex is More Extensive But Independent of the Cid Region
J.Struct.Biol., 195, 2016
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5GAP | | BODY REGION OF THE U4/U6.U5 TRI-SNRNP | | Descriptor: | unknown protein, Pre-mRNA-splicing factor 8, U4/U6 small nuclear ribonucleoprotein PRP4, Pre-mRNA-splicing factor 6, Spliceosomal protein DIB1, Pre-mRNA-processing factor 31, U4/U6 small nuclear ribonucleoprotein PRP3, 13 kDa ribonucleoprotein-associated protein, Pre-mRNA-splicing helicase BRR2/RNA Complex | | Authors: | Nguyen, T.H.D., Galej, W.P., Oubridge, C., Bai, X.C., Newman, A., Scheres, S., Nagai, K. | | Deposit date: | 2015-12-15 | | Release date: | 2016-01-27 | | Last modified: | 2016-03-09 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
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5MZ6 | | CRYO-EM STRUCTURE OF A SEPARASE-SECURIN COMPLEX FROM CAENORHABDITIS ELEGANS AT 3.8 A RESOLUTION | | Descriptor: | SEParase, Interactor of FizzY protein | | Authors: | Boland, A., Martin, T.G., Zhang, Z., Yang, J., Bai, X.C., Chang, L., Scheres, S.H.W., Barford, D. | | Deposit date: | 2017-01-31 | | Release date: | 2017-03-08 | | Last modified: | 2017-04-19 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.
Nat. Struct. Mol. Biol., 24, 2017
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4V5X | |
5MPS | | STRUCTURE OF A SPLICEOSOME REMODELED FOR EXON LIGATION | | Descriptor: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, Pre-mRNA-splicing factor CWC22, Pre-mRNA-splicing factor PRP46, Pre-mRNA-processing protein 45, Pre-mRNA-splicing factor BUD31, Pre-mRNA-splicing factor CWC2, Pre-mRNA-splicing factor SLT11, Pre-mRNA-splicing factor CEF1, Pre-mRNA-splicing factor CWC15, Pre-mRNA-splicing factor CWC21, Pre-mRNA-splicing factor CLF1, Pre-mRNA-splicing factor SYF1, Pre-mRNA-splicing factor 18, Pre-mRNA-splicing factor SLU7, Pre-mRNA-processing factor 17, Unknown, Pre-mRNA-splicing factor SYF2, Small nuclear ribonucleoprotein-associated protein B, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2/RNA Complex | | Authors: | Fica, S.M., Oubridge, C., Galej, W.P., Wilkinson, M.E., Newman, A.J., Bai, X.-C., Nagai, K. | | Deposit date: | 2016-12-18 | | Release date: | 2017-01-18 | | Last modified: | 2017-03-01 | | Method: | ELECTRON MICROSCOPY (3.85 Å) | | Cite: | Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
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5MQ0 | | STRUCTURE OF A SPLICEOSOME REMODELED FOR EXON LIGATION | | Descriptor: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, Pre-mRNA-splicing factor CWC22, Pre-mRNA-splicing factor PRP46, Pre-mRNA-processing protein 45, Pre-mRNA-splicing factor BUD31, Pre-mRNA-splicing factor CEF1, Pre-mRNA-splicing factor CWC15, Pre-mRNA-splicing factor CWC21, Pre-mRNA-splicing factor CLF1, Pre-mRNA-splicing factor SYF1, Pre-mRNA-splicing factor 18, Pre-mRNA-splicing factor SLU7, Pre-mRNA-splicing factor SYF2, Small nuclear ribonucleoprotein-associated protein B, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2, Pre-mRNA-splicing factor CWC2, Pre-mRNA-splicing factor SLT11, Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, Pre-mRNA-processing factor 17, U2 small nuclear ribonucleoprotein A', U2 small nuclear ribonucleoprotein B'', Unknown protein/RNA Complex | | Authors: | Fica, S.M., Oubridge, C., Galej, W.P., Wilkinson, M.E., Newman, A.J., Bai, X.-C., Nagai, K. | | Deposit date: | 2016-12-19 | | Release date: | 2017-01-18 | | Last modified: | 2017-03-01 | | Method: | ELECTRON MICROSCOPY (4.17 Å) | | Cite: | Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
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3J8H | | STRUCTURE OF THE RABBIT RYANODINE RECEPTOR RYR1 IN COMPLEX WITH FKBP12 AT 3.8 ANGSTROM RESOLUTION | | Descriptor: | Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A (E.C.5.2.1.8) | | Authors: | Yan, Z., Bai, X., Yan, C., Wu, J., Scheres, S.H.W., Shi, Y., Yan, N. | | Deposit date: | 2014-10-26 | | Release date: | 2014-12-10 | | Last modified: | 2015-02-25 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution.
Nature, 517, 2015
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3J9K | | STRUCTURE OF DARK APOPTOSOME IN COMPLEX WITH DRONC CARD DOMAIN | | Descriptor: | Apaf-1 related killer DARK, Caspase Nc (E.C.3.4.22.-) | | Authors: | Pang, Y., Bai, X., Yan, C., Hao, Q., Chen, Z., Wang, J., Scheres, S.H.W., Shi, Y. | | Deposit date: | 2015-02-04 | | Release date: | 2015-02-25 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila.
Genes Dev., 29, 2015
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