Author results

5FN2
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CRYO-EM STRUCTURE OF GAMMA SECRETASE IN COMPLEX WITH A DRUG DAPT
Descriptor:NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2
Authors:Bai, X.C., Rajendra, E., Yang, G.H., Shi, Y.G., Scheres, S.H.W.
Deposit date:2015-11-10
Release date:2015-12-16
Last modified:2016-12-21
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
5FN3
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CRYO-EM STRUCTURE OF GAMMA SECRETASE IN CLASS 1 OF THE APO- STATE ENSEMBLE
Descriptor:NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2, POLY ALA CHAIN
Authors:Bai, X.C., Rajendra, E., Yang, G.H., Shi, Y.G., Scheres, S.H.W.
Deposit date:2015-11-10
Release date:2015-12-16
Last modified:2016-12-21
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
5FN4
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CRYO-EM STRUCTURE OF GAMMA SECRETASE IN CLASS 2 OF THE APO- STATE ENSEMBLE
Descriptor:NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2, POLY ALA CHAIN
Authors:Bai, X.C., Rajendra, E., Yang, G.H., Shi, Y.G., Scheres, S.H.W.
Deposit date:2015-11-10
Release date:2015-12-16
Last modified:2016-12-21
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
5FN5
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CRYO-EM STRUCTURE OF GAMMA SECRETASE IN CLASS 3 OF THE APO- STATE ENSEMBLE
Descriptor:NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2
Authors:Bai, X.C., Rajendra, E., Yang, G.H., Shi, Y.G., Scheres, S.H.W.
Deposit date:2015-11-10
Release date:2015-12-16
Last modified:2016-12-21
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
5GKY
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STRUCTURE OF RYR1 IN A CLOSED STATE (C1 CONFORMER)
Descriptor:RyR1, FKBP12
Authors:Bai, X.C., Yan, Z., Wu, J.P., Yan, N.
Deposit date:2016-07-07
Release date:2016-08-24
Last modified:2016-09-14
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Cell Res., 26, 2016
5GKZ
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STRUCTURE OF RYR1 IN A CLOSED STATE (C3 CONFORMER)
Descriptor:Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A (E.C.5.2.1.8)
Authors:Bai, X.C., Yan, Z., Wu, J.P., Yan, N.
Deposit date:2016-07-07
Release date:2016-08-24
Last modified:2016-09-14
Method:ELECTRON MICROSCOPY (4 Å)
Cite:The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Cell Res., 26, 2016
5GL0
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STRUCTURE OF RYR1 IN A CLOSED STATE (C4 CONFORMER)
Descriptor:Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A (E.C.5.2.1.8)
Authors:Bai, X.C., Yan, Z., Wu, J.P., Yan, N.
Deposit date:2016-07-07
Release date:2016-08-24
Last modified:2016-09-14
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Cell Res., 26, 2016
5GL1
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STRUCTURE OF RYR1 IN AN OPEN STATE
Descriptor:Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A (E.C.5.2.1.8)
Authors:Bai, X.C., Yan, Z., Wu, J.P., Yan, N.
Deposit date:2016-07-07
Release date:2016-08-24
Last modified:2016-09-14
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Cell Res., 26, 2016
5GAM
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FOOT REGION OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP
Descriptor:Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, Small nuclear ribonucleoprotein-associated protein B, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, Unknown polypeptide, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2/RNA Complex
Authors:Nguyen, T.H.D., Galej, W.P., Bai, X.C., Oubridge, C., Scheres, S.H.W., Newman, A.J., Nagai, K.
Deposit date:2015-12-15
Release date:2016-02-03
Last modified:2016-10-12
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution
Nature, 530, 2016
5GAN
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THE OVERALL STRUCTURE OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP AT 3.7 ANGSTROM
Descriptor:Pre-mRNA-splicing factor 8, U4/U6 small nuclear ribonucleoprotein PRP4, Pre-mRNA-splicing factor 6, Spliceosomal protein DIB1, Pre-mRNA-processing factor 31, U4/U6 small nuclear ribonucleoprotein PRP3, Pre-mRNA-splicing helicase BRR2, Unknown protein, Small nuclear ribonucleoprotein-associated protein B, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, Snu66, 13 kDa ribonucleoprotein-associated protein, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, U6 snRNA-associated Sm-like protein LSm4, U6 snRNA-associated Sm-like protein LSm5, U6 snRNA-associated Sm-like protein LSm6, U6 snRNA-associated Sm-like protein LSm7, U6 snRNA-associated Sm-like protein LSm8, Pre-mRNA-splicing factor SNU114/RNA Complex
Authors:Nguyen, T.H.D., Galej, W.P., Bai, X.C., Oubridge, C., Scheres, S.H.W., Newman, A.J., Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2016-05-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5GAO
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HEAD REGION OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP
Descriptor:Small nuclear ribonucleoprotein-associated protein B, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, Snu66, Pre-mRNA-splicing helicase BRR2, Pre-mRNA-splicing factor 8/RNA Complex
Authors:Nguyen, T.H.D., Galej, W.P., Bai, X.C., Oubridge, C., Scheres, S.H.W., Newman, A.J., Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2016-03-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
3J6B
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STRUCTURE OF THE YEAST MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT
Descriptor:PROTEIN/RNA Complex
Authors:Amunts, A., Brown, A., Bai, X.C., Llacer, J.L., Hussain, T., Emsley, P., Long, F., Murshudov, G., Scheres, S.H.W., Ramakrishnan, V.
Deposit date:2014-01-22
Release date:2014-04-09
Last modified:2014-12-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the yeast mitochondrial large ribosomal subunit.
Science, 343, 2014
3J79
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CRYO-EM STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTI-PROTOZOAN DRUG EMETINE, LARGE SUBUNIT
Descriptor:PROTEIN/RNA Complex
Authors:Wong, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W.
Deposit date:2014-06-02
Release date:2014-07-16
Last modified:2015-06-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
3J7A
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CRYO-EM STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTI-PROTOZOAN DRUG EMETINE, SMALL SUBUNIT
Descriptor:PROTEIN/RNA Complex
Authors:Wong, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W.
Deposit date:2014-06-03
Release date:2014-07-16
Last modified:2015-06-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
3J7Y
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STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM HUMAN MITOCHONDRIA
Descriptor:PROTEIN/RNA Complex
Authors:Brown, A., Amunts, A., Bai, X.C., Sugimoto, Y., Edwards, P.C., Murshudov, G., Scheres, S.H.W., Ramakrishnan, V.
Deposit date:2014-08-26
Release date:2014-10-15
Last modified:2014-11-19
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the large ribosomal subunit from human mitochondria.
Science, 346, 2014
4V8Y
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CRYO-EM RECONSTRUCTION OF THE 80S-EIF5B-MET-ITRNAMET EUKARYOTIC TRANSLATION INITIATION COMPLEX
Descriptor:80S Ribosome
Authors:Fernandez, I.S., Bai, X.C., Hussain, T., Kelley, A.C., Lorsch, J.R., Ramakrishnan, V., Scheres, S.H.W.
Deposit date:2013-07-20
Release date:2014-07-09
Last modified:2014-12-10
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Molecular Architecture of a Eukaryotic Translational Initiation Complex.
Science, 342, 2013
4V8Z
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CRYO-EM RECONSTRUCTION OF THE 80S-EIF5B-MET-ITRNAMET EUKARYOTIC TRANSLATION INITIATION COMPLEX
Descriptor:80S Ribosome
Authors:Fernandez, I.S., Bai, X.C., Hussain, T., Kelley, A.C., Lorsch, J.R., Ramakrishnan, V., Scheres, S.H.W.
Deposit date:2013-07-20
Release date:2014-07-09
Last modified:2014-12-10
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Molecular Architecture of a Eukaryotic Translational Initiation Complex.
Science, 342, 2013
5G5P
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STRUCTURE OF THE SACCHAROMYCES CEREVISIAE TREX-2 COMPLEX
Descriptor:NUCLEAR MRNA EXPORT PROTEIN SAC3, NUCLEAR MRNA EXPORT PROTEIN THP1, 26S PROTEASOME COMPLEX SUBUNIT SEM1
Authors:Aibara, S., Bai, X.C., Stewart, M.
Deposit date:2016-05-26
Release date:2016-11-23
Last modified:2016-12-14
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:The Sac3 Tpr-Like Region in the Saccharomyces Cerevisiae Trex-2 Complex is More Extensive But Independent of the Cid Region
J.Struct.Biol., 195, 2016
5GAP
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BODY REGION OF THE U4/U6.U5 TRI-SNRNP
Descriptor:unknown protein, Pre-mRNA-splicing factor 8, U4/U6 small nuclear ribonucleoprotein PRP4, Pre-mRNA-splicing factor 6, Spliceosomal protein DIB1, Pre-mRNA-processing factor 31, U4/U6 small nuclear ribonucleoprotein PRP3, 13 kDa ribonucleoprotein-associated protein, Pre-mRNA-splicing helicase BRR2/RNA Complex
Authors:Nguyen, T.H.D., Galej, W.P., Oubridge, C., Bai, X.C., Newman, A., Scheres, S., Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2016-03-09
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5MZ6
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CRYO-EM STRUCTURE OF A SEPARASE-SECURIN COMPLEX FROM CAENORHABDITIS ELEGANS AT 3.8 A RESOLUTION
Descriptor:SEParase, Interactor of FizzY protein
Authors:Boland, A., Martin, T.G., Zhang, Z., Yang, J., Bai, X.C., Chang, L., Scheres, S.H.W., Barford, D.
Deposit date:2017-01-31
Release date:2017-03-08
Last modified:2017-04-19
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.
Nat. Struct. Mol. Biol., 24, 2017
4V5X
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THE CRYO-EM STRUCTURE OF A 3D DNA-ORIGAMI OBJECT
Descriptor:DNA-origami object
Authors:Bai, X.C., Martin, T.G., Scheres, S.H.W., Dietz, H.
Deposit date:2012-10-09
Release date:2014-07-09
Last modified:2014-12-10
Method:ELECTRON MICROSCOPY (11.5 Å)
Cite:Cryo-Em Structure of a 3D DNA-Origami Object.
Proc.Natl.Acad.Sci.USA, 109, 2012
5MPS
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STRUCTURE OF A SPLICEOSOME REMODELED FOR EXON LIGATION
Descriptor:Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, Pre-mRNA-splicing factor CWC22, Pre-mRNA-splicing factor PRP46, Pre-mRNA-processing protein 45, Pre-mRNA-splicing factor BUD31, Pre-mRNA-splicing factor CWC2, Pre-mRNA-splicing factor SLT11, Pre-mRNA-splicing factor CEF1, Pre-mRNA-splicing factor CWC15, Pre-mRNA-splicing factor CWC21, Pre-mRNA-splicing factor CLF1, Pre-mRNA-splicing factor SYF1, Pre-mRNA-splicing factor 18, Pre-mRNA-splicing factor SLU7, Pre-mRNA-processing factor 17, Unknown, Pre-mRNA-splicing factor SYF2, Small nuclear ribonucleoprotein-associated protein B, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2/RNA Complex
Authors:Fica, S.M., Oubridge, C., Galej, W.P., Wilkinson, M.E., Newman, A.J., Bai, X.-C., Nagai, K.
Deposit date:2016-12-18
Release date:2017-01-18
Last modified:2017-03-01
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
5MQ0
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STRUCTURE OF A SPLICEOSOME REMODELED FOR EXON LIGATION
Descriptor:Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, Pre-mRNA-splicing factor CWC22, Pre-mRNA-splicing factor PRP46, Pre-mRNA-processing protein 45, Pre-mRNA-splicing factor BUD31, Pre-mRNA-splicing factor CEF1, Pre-mRNA-splicing factor CWC15, Pre-mRNA-splicing factor CWC21, Pre-mRNA-splicing factor CLF1, Pre-mRNA-splicing factor SYF1, Pre-mRNA-splicing factor 18, Pre-mRNA-splicing factor SLU7, Pre-mRNA-splicing factor SYF2, Small nuclear ribonucleoprotein-associated protein B, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2, Pre-mRNA-splicing factor CWC2, Pre-mRNA-splicing factor SLT11, Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, Pre-mRNA-processing factor 17, U2 small nuclear ribonucleoprotein A', U2 small nuclear ribonucleoprotein B'', Unknown protein/RNA Complex
Authors:Fica, S.M., Oubridge, C., Galej, W.P., Wilkinson, M.E., Newman, A.J., Bai, X.-C., Nagai, K.
Deposit date:2016-12-19
Release date:2017-01-18
Last modified:2017-03-01
Method:ELECTRON MICROSCOPY (4.17 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
3J8H
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STRUCTURE OF THE RABBIT RYANODINE RECEPTOR RYR1 IN COMPLEX WITH FKBP12 AT 3.8 ANGSTROM RESOLUTION
Descriptor:Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A (E.C.5.2.1.8)
Authors:Yan, Z., Bai, X., Yan, C., Wu, J., Scheres, S.H.W., Shi, Y., Yan, N.
Deposit date:2014-10-26
Release date:2014-12-10
Last modified:2015-02-25
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution.
Nature, 517, 2015
3J9K
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STRUCTURE OF DARK APOPTOSOME IN COMPLEX WITH DRONC CARD DOMAIN
Descriptor:Apaf-1 related killer DARK, Caspase Nc (E.C.3.4.22.-)
Authors:Pang, Y., Bai, X., Yan, C., Hao, Q., Chen, Z., Wang, J., Scheres, S.H.W., Shi, Y.
Deposit date:2015-02-04
Release date:2015-02-25
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila.
Genes Dev., 29, 2015
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