Author results

1HUO
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CRYSTAL STRUCTURE OF DNA POLYMERASE BETA COMPLEXED WITH DNA AND CR-TMPPCP
分子名称:5'-D(*AP*AP*TP*AP*GP*GP*CP*GP*TP*CP*G)-3', 5'-D(P*CP*GP*AP*CP*GP*CP*C)-3', DNA POLYMERASE BETA, ...
著者Arndt, J.W., Gong, W., Zhong, X., Showalter, A.K., Liu, J., Lin, Z., Paxson, C., Tsai, M.-D., Chan, M.K.
登録日2001-01-04
公開日2001-04-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.
Biochemistry, 40, 2001
1HUZ
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CRYSTAL STRUCTURE OF DNA POLYMERASE COMPLEXED WITH DNA AND CR-PCP
分子名称:5'-D(*AP*AP*TP*AP*GP*GP*CP*GP*TP*CP*G)-3', 5'-D(P*CP*GP*AP*CP*GP*CP*CP*T)-3', DNA POLYMERASE BETA, ...
著者Arndt, J.W., Gong, W., Zhong, X., Showalter, A.K., Liu, J., Lin, Z., Paxson, C., Tsai, M.-D., Chan, M.K.
登録日2001-01-04
公開日2001-04-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.
Biochemistry, 40, 2001
1K9X
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STRUCTURE OF PYROCOCCUS FURIOSUS CARBOXYPEPTIDASE APO-YB
分子名称:M32 carboxypeptidase
著者Arndt, J.W., Hao, B., Ramakrishnan, V., Cheng, T., Chan, S.I., Chan, M.K.
登録日2001-10-31
公開日2002-11-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of a Novel Carboxypeptidase from the Hyperthermophilic Archaeon Pyrococcus furiosus
Structure, 10, 2002
1KA2
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STRUCTURE OF PYROCOCCUS FURIOSUS CARBOXYPEPTIDASE APO-MG
分子名称:M32 carboxypeptidase, MAGNESIUM ION
著者Arndt, J.W., Hao, B., Ramakrishnan, V., Cheng, T., Chan, S.I., Chan, M.K.
登録日2001-10-31
公開日2002-11-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of a Novel Carboxypeptidase from the Hyperthermophilic Archaeon Pyrococcus furiosus
Structure, 10, 2002
1KA4
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STRUCTURE OF PYROCOCCUS FURIOSUS CARBOXYPEPTIDASE NAT-PB
分子名称:M32 carboxypeptidase, LEAD (II) ION
著者Arndt, J.W., Hao, B., Ramakrishnan, V., Cheng, T., Chan, S.I., Chan, M.K.
登録日2001-10-31
公開日2002-11-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal Structure of a Novel Carboxypeptidase from the Hyperthermophilic Archaeon Pyrococcus furiosus
Structure, 10, 2002
1YBI
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CRYSTAL STRUCTURE OF HA33A, A NEUROTOXIN-ASSOCIATED PROTEIN FROM CLOSTRIDIUM BOTULINUM TYPE A
分子名称:non-toxin haemagglutinin HA34
著者Arndt, J.W., Gu, J., Jaroszewski, L., Schwarzenbacher, R., Hanson, M., Lebeda, F.J., Stevens, R.C.
登録日2004-12-20
公開日2005-02-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The Structure of the Neurotoxin-associated Protein HA33/A from Clostridium botulinum Suggests a Reoccurring beta-Trefoil Fold in the Progenitor Toxin Complex.
J.Mol.Biol., 346, 2005
1ZB7
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CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN TYPE G LIGHT CHAIN
分子名称:neurotoxin, ZINC ION, CITRATE ANION
著者Arndt, J.W., Yu, W., Bi, F., Stevens, R.C.
登録日2005-04-07
公開日2005-07-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of botulinum neurotoxin type g light chain: serotype divergence in substrate recognition
Biochemistry, 44, 2005
2FPQ
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CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN TYPE D LIGHT CHAIN
分子名称:BOTULINUM NEUROTOXIN D LIGHT CHAIN, ZINC ION, POTASSIUM ION
著者Arndt, J.W., Chai, Q., Christian, T., Stevens, R.C.
登録日2006-01-16
公開日2006-03-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure of Botulinum Neurotoxin Type D Light Chain at 1.65 A Resolution: Repercussions for VAMP-2 Substrate Specificity(,).
Biochemistry, 45, 2006
6CNR
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ADUCANUMAB APO FAB
分子名称:Aducanumab light chain, Aducanumab heavy chain, SULFATE ION
著者Arndt, J.W.
登録日2018-03-08
公開日2018-05-02
最終更新日2018-05-09
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta.
Sci Rep, 8, 2018
6CO3
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ADUCANUMAB ABETA COMPLEX
分子名称:Fab light chain, Fab heavy chain, ALA-GLU-PHE-ARG-HIS-ASP, ...
著者Arndt, J.W.
登録日2018-03-10
公開日2018-05-02
最終更新日2018-05-09
実験手法X-RAY DIFFRACTION (2.384 Å)
主引用文献Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta.
Sci Rep, 8, 2018
3HC0
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BHA10 IGG1 WILD-TYPE FAB - ANTIBODY DIRECTED AT HUMAN LTBR
分子名称:IMMUNOGLOBULIN IGG1 FAB, LIGHT CHAIN, HEAVY CHAIN, ...
著者Arndt, J.W., Jordan, J.L., Lugovskoy, A., Wang, D.
登録日2009-05-05
公開日2009-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules
Proteins, 77, 2009
3HC3
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BHA10 IGG1 FAB DOUBLE MUTANT VARIANT - ANTIBODY DIRECTED AT HUMAN LTBR
分子名称:IMMUNOGLOBULIN IGG1 FAB, LIGHT CHAIN, HEAVY CHAIN, ...
著者Arndt, J.W., Jordan, J.L., Lugovskoy, A., Wang, D.
登録日2009-05-05
公開日2009-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules
Proteins, 77, 2009
3HC4
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BHA10 IGG1 FAB QUADRUPLE MUTANT VARIANT - ANTIBODY DIRECTED AT HUMAN LTBR
分子名称:IMMUNOGLOBULIN IGG1 FAB, HEAVY CHAIN, LIGHT CHAIN, ...
著者Arndt, J.W., Jordan, J.L., Lugovskoy, A., Wang, D.
登録日2009-05-05
公開日2009-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules
Proteins, 77, 2009
3NMQ
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HSP90B N-TERMINAL DOMAIN IN COMPLEX WITH EC44, A PYRROLO-PYRIMIDINE METHOXYPYRIDINE INHIBITOR
分子名称:Heat shock protein HSP 90-beta, 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2-ol
著者Arndt, J.W., Yun, T.J., Harning, E.K., Giza, K., Rabah, D., Li, P., Luchetti, D., Shi, J., Manning, A., Kehry, M.R.
登録日2010-06-22
公開日2010-12-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity.
J.Immunol., 186, 2011
3QC4
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PDK1 IN COMPLEX WITH DFG-OUT INHIBITOR XXX
分子名称:3-phosphoinositide-dependent protein kinase 1, 1-(3,4-difluorobenzyl)-2-oxo-N-{(1R)-2-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide
著者Arndt, J.W.
登録日2011-01-15
公開日2011-04-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
Bioorg.Med.Chem.Lett., 21, 2011
4KY1
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HUMANIZED HP1/2 FAB
分子名称:IMMUNOGLOBULIN IGG1 FAB, LIGHT CHAIN, HEAVY CHAIN
著者Arndt, J.W., Hanf, K.J.M., Lugovskoy, A., Chen, L.L., Jarpe, M., Boriack-Sjodin, A., Li, Y., van Vlijmen, H., Pepinsky, B., Taylor, F., Silvian, L., Taveras, A.
登録日2013-05-28
公開日2013-07-24
最終更新日2014-01-22
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework.
METHODS (SAN DIEGO), 65, 2014
6CT7
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FAB OF ANTI-A-SYNUCLEIN ANTIBODY BIIB054 IN COMPLEX WITH ACETYLATED A-SYNUCLEIN PEPTIDE (1-10)
分子名称:BIIB054 Fab light chain, BIIB054 Fab heavy chain, ACE-MET-ASP-VAL-PHE-MET-LYS-GLY-LEU-SER-LYS, ...
著者Arndt, J.W.
登録日2018-03-22
公開日2018-12-19
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (1.903 Å)
主引用文献Development of an aggregate-selective, human-derived alpha-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
Neurobiol. Dis., 124, 2018
2NP0
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CRYSTAL STRUCTURE OF THE BOTULINUM NEUROTOXIN TYPE B COMPLEXED WITH SYNAPTOTAGAMIN-II ECTODOMAIN
分子名称:Botulinum neurotoxin type B, Synaptotagmin-2, ZINC ION, ...
著者Chai, Q., Arndt, J.W., Stevens, R.C.
登録日2006-10-26
公開日2006-12-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Structural basis of cell surface receptor recognition by botulinum neurotoxin B.
Nature, 444, 2006
2NYY
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CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN TYPE A COMPLEXED WITH MONOCLONAL ANTIBODY CR1
分子名称:Botulinum neurotoxin type A, CR1 monoclonal antibody, ZINC ION, ...
著者Stevens, R.C., Arndt, J.W.
登録日2006-11-21
公開日2006-12-26
最終更新日2016-02-17
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin.
Nat.Biotechnol., 25, 2007
2NZ9
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CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN TYPE A COMPLEXED WITH MONOCLONAL ANTIBODY AR2
分子名称:Botulinum neurotoxin type A, AR2 monoclonal antibody, ZINC ION, ...
著者Stevens, R.C., Arndt, J.W.
登録日2006-11-22
公開日2006-12-26
最終更新日2016-02-17
実験手法X-RAY DIFFRACTION (3.79 Å)
主引用文献Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin.
Nat.Biotechnol., 25, 2007
4OQT
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LINGO-1/LI81 FAB COMPLEX
分子名称:Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Light Chain of Li81 Fab, kappa 3, ...
著者Pepinsky, R.B., Arndt, J.W., Quan, C., Gao, Y., Quintero-Monzon, O., Lee, X., Mi, S.
登録日2014-02-10
公開日2014-05-14
最終更新日2014-06-18
実験手法X-RAY DIFFRACTION (3.23 Å)
主引用文献Structure of the LINGO-1-Anti-LINGO-1 Li81 Antibody Complex Provides Insights into the Biology of LINGO-1 and the Mechanism of Action of the Antibody Therapy.
J.Pharmacol.Exp.Ther., 350, 2014
6N29
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CRYSTAL STRUCTURE OF MONOMERIC VON WILLEBRAND FACTOR D`D3 ASSEMBLY
分子名称:von Willebrand factor, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
著者Dong, X., Arndt, J.W., Springer, T.A.
登録日2018-11-12
公開日2019-01-23
最終更新日2019-02-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis.
Blood, 2019
3QDD
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HSP90A N-TERMINAL DOMAIN IN COMPLEX WITH BIIB021
分子名称:Heat shock protein HSP 90-alpha, 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine
著者Arndt, J.W., Biamonte, M.A.
登録日2011-01-18
公開日2012-07-18
最終更新日2012-09-26
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献EC144 Is a Potent Inhibitor of the Heat Shock Protein 90.
J.Med.Chem., 55, 2012
6CR1
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ADALIMUMAB EFAB
分子名称:Light chain of adalimumab EFab (VL-IgE CH2), Heavy chain of adalimumab EFab (VH-IgE CH2), DI(HYDROXYETHYL)ETHER, ...
著者Arndt, J.W.
登録日2018-03-16
公開日2018-09-26
最終更新日2018-11-28
実験手法X-RAY DIFFRACTION (1.521 Å)
主引用文献EFab domain substitution as a solution to the light-chain pairing problem of bispecific antibodies.
MAbs, 10, 2018
1VKH
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CRYSTAL STRUCTURE OF A PUTATIVE SERINE HYDROLASE (YDR428C) FROM SACCHAROMYCES CEREVISIAE AT 1.85 A RESOLUTION
分子名称:putative serine hydrolase, GLYCEROL, CHLORIDE ION
著者Joint Center for Structural Genomics (JCSG)
登録日2004-05-20
公開日2004-06-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution
Proteins, 58, 2005
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