2NP0

Crystal structure of the Botulinum neurotoxin type B complexed with synaptotagamin-II ectodomain

Summary for 2NP0

Entry DOI	10.2210/pdb2np0/pdb
Descriptor	Botulinum neurotoxin type B, Synaptotagmin-2, ZINC ION, ... (6 entities in total)
Functional Keywords	botulinum, neurotoxin, synaptotagamin, receptor, hydrolase
Biological source	Mus musculus (house mouse) More
Cellular location	Botulinum neurotoxin B light chain: Secreted. Botulinum neurotoxin B heavy chain: Secreted: P10844 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein: P46097
Total number of polymer chains	2
Total formula weight	153591.32
Authors	Chai, Q.,Arndt, J.W.,Stevens, R.C. (deposition date: 2006-10-26, release date: 2006-12-26, Last modification date: 2023-08-30)
Primary citation	Chai, Q.,Arndt, J.W.,Dong, M.,Tepp, W.H.,Johnson, E.A.,Chapman, E.R.,Stevens, R.C. Structural basis of cell surface receptor recognition by botulinum neurotoxin B. Nature, 444:1096-1100, 2006 Cited by PubMed: 17167418 DOI: 10.1038/nature05411 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.62 Å)

Structure validation