Author results

5E0O
  • Download 5e0o
  • View 5e0o
Molmil generated image of 5e0o
BRUGIA MALAYI TREHALOSE-6 PHOSPHATE PHOSPHATASE IN COMPLEX WITH PEG AT THE ACTIVE SITE.
Descriptor:Trehalose-phosphatase, MAGNESIUM ION, SULFATE ION, ...
Authors:Agarwal, A., Misra-Bhattacharya, S., Ravishankar, R.
Deposit date:2015-09-29
Release date:2015-10-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Brugia malayi Trehalose Phosphate Phosphatase in complex with PEG at the active site
To Be Published, 2015
2GC8
  • Download 2gc8
  • View 2gc8
Molmil generated image of 2gc8
STRUCTURE OF A PROLINE SULFONAMIDE INHIBITOR BOUND TO HCV NS5B POLYMERASE
Descriptor:RNA-directed RNA polymerase, 1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE
Authors:Gopalsamy, A., Chopra, R., Lim, K., Ciszewski, G., Shi, M., Curran, K.J., Sukits, S.F., Svenson, K., Bard, J., Ellingboe, J.W., Agarwal, A., Krishnamurthy, G., Howe, A.Y., Orlowski, M., Feld, B., O'connell, J., Mansour, T.S.
Deposit date:2006-03-13
Release date:2006-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of Proline Sulfonamides as Potent and Selective Hepatitis C Virus NS5b Polymerase Inhibitors. Evidence for a New NS5b Polymerase Binding Site.
J.Med.Chem., 49, 2006
2A6D
  • Download 2a6d
  • View 2a6d
Molmil generated image of 2a6d
CRYSTAL STRUCTURE ANALYSIS OF THE ANTI-ARSONATE GERMLINE ANTIBODY 36-65 IN COMPLEX WITH A PHAGE DISPLAY DERIVED DODECAPEPTIDE RLLIADPPSPRE
Descriptor:Germline antibody 36-65 Fab light chain, Germline antibody 36-65 Fab Heavy chain, Dodecapeptide, ...
Authors:Sethi, D.K., Agarwal, A., Manivel, V., Rao, K.V., Salunke, D.M.
Deposit date:2005-07-02
Release date:2006-06-13
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response.
Immunity, 24, 2006
2A6I
  • Download 2a6i
  • View 2a6i
Molmil generated image of 2a6i
CRYSTAL STRUCTURE ANALYSIS OF THE ANTI-ARSONATE GERMLINE ANTIBODY 36-65 IN COMPLEX WITH A PHAGE DISPLAY DERIVED DODECAPEPTIDE KLASIPTHTSPL
Descriptor:Germline antibody 36-65 Fab light chain, Germline antibody 36-65 Fab heavy chain, Dodecapeptide: KLASIPTHTSPL
Authors:Sethi, D.K., Agarwal, A., Manivel, V., Rao, K.V., Salunke, D.M.
Deposit date:2005-07-02
Release date:2006-06-13
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response.
Immunity, 24, 2006
2A6J
  • Download 2a6j
  • View 2a6j
Molmil generated image of 2a6j
CRYSTAL STRUCTURE ANALYSIS OF THE ANTI-ARSONATE GERMLINE ANTIBODY 36-65
Descriptor:Germline antibody 36-65 Fab light chain, Germline antibody 36-65 Fab heavy chain
Authors:Sethi, D.K., Agarwal, A., Manivel, V., Rao, K.V., Salunke, D.M.
Deposit date:2005-07-02
Release date:2006-06-13
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response.
Immunity, 24, 2006
2A6K
  • Download 2a6k
  • View 2a6k
Molmil generated image of 2a6k
CRYSTAL STRUCTURE ANALYSIS OF THE GERMLINE ANTIBODY 36-65 FAB IN COMPLEX WITH THE DODECAPEPTIDE SLGDNLTNHNLR
Descriptor:Germline antibody 36-65 Fab light chain, Germline antibody 36-65 Fab heavy chain, DODECAPEPTIDE: SLGDNLTNHNLR
Authors:Sethi, D.K., Agarwal, A., Manivel, V., Rao, K.V., Salunke, D.M.
Deposit date:2005-07-03
Release date:2006-06-13
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response.
Immunity, 24, 2006
1Q2P
  • Download 1q2p
  • View 1q2p
Molmil generated image of 1q2p
SHV-1 CLASS A BETA-LACTAMASE COMPLEXED WITH PENEM WAY185229
Descriptor:beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, (6,7-DIHYDRO-5H-CYCLOPENTA[D]IMIDAZO[2,1-B]THIAZOL-2-YL]-4,7-DIHYDRO[1,4]THIAZEPINE-3,6-DICARBOXYLIC ACID
Authors:Nukaga, M., Venkatesan, A.M., Mansour, T.S., Hujer, A., Bonomo, R.A., Knox, J.R.
Deposit date:2003-07-25
Release date:2004-09-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates
J.Med.Chem., 47, 2004
1Q2Q
  • Download 1q2q
  • View 1q2q
Molmil generated image of 1q2q
ENTEROBACTER CLOACAE GC1 CLASS C BETA-LACTAMASE COMPLEXED WITH PENEM WAY185229
Descriptor:class C beta-lactamase, (6,7-DIHYDRO-5H-CYCLOPENTA[D]IMIDAZO[2,1-B]THIAZOL-2-YL]-4,7-DIHYDRO[1,4]THIAZEPINE-3,6-DICARBOXYLIC ACID, GLYCEROL
Authors:Nukaga, M., Venkatesan, A.M., Mansour, T.S., Hujer, A., Bonomo, R.A., Knox, J.R.
Deposit date:2003-07-25
Release date:2004-09-14
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates
J.Med.Chem., 47, 2004
2QE2
  • Download 2qe2
  • View 2qe2
Molmil generated image of 2qe2
STRUCTURE OF HCV NS5B BOUND TO AN ANTHRANILIC ACID INHIBITOR
Descriptor:RNA-directed RNA polymerase, 2-{[N-(2-ACETYL-5-CHLORO-4-FLUOROPHENYL)GLYCYL]AMINO}BENZOIC ACID
Authors:Chopra, R., Svenson, K., Bard, J.
Deposit date:2007-06-22
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase
J.Med.Chem., 50, 2007
2QE5
  • Download 2qe5
  • View 2qe5
Molmil generated image of 2qe5
STRUCTURE OF HCV NS5B BOUND TO AN ANTHRANILIC ACID INHIBITOR
Descriptor:RNA-directed RNA polymerase, 2-{[(4-CHLOROPHENOXY)ACETYL]AMINO}BENZOIC ACID
Authors:Chopra, R., Svenson, K., Bard, J.
Deposit date:2007-06-22
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase
J.Med.Chem., 50, 2007
2JJE
  • Download 2jje
  • View 2jje
Molmil generated image of 2jje
CRYSTAL STRUCTURE OF T330S MUTANT OF RV3290C FROM M. TUBERCULOSIS
Descriptor:L-LYSINE EPSILON AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Tripathi, S.M., Ramachandran, R.
Deposit date:2008-04-03
Release date:2009-06-30
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mutational Analysis of Mycobacterium Tuberculosis Lysine Epsilon-Aminotransferase and Inhibitor Co-Crystal Structures, Reveals Distinct Binding Modes.
Biochem.Biophys.Res.Commun., 463, 2015
2JJF
  • Download 2jjf
  • View 2jjf
Molmil generated image of 2jjf
N328A MUTANT OF M. TUBERCULOSIS RV3290C
Descriptor:L-LYSINE EPSILON AMINOTRANSFERASE
Authors:tripathi, S.M., Ramachandran, R.
Deposit date:2008-04-04
Release date:2009-06-30
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mutational Analysis of Mycobacterium Tuberculosis Lysine Epsilon-Aminotransferase and Inhibitor Co-Crystal Structures, Reveals Distinct Binding Modes.
Biochem.Biophys.Res.Commun., 463, 2015
2JJG
  • Download 2jjg
  • View 2jjg
Molmil generated image of 2jjg
CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS LYSINE-EPSILON AMINOTRANSFERASE (RV3290C) COMPLEXED TO AN INHIBITOR
Descriptor:L-LYSINE EPSILON AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, (2S)-1-methyl-2-[(2S,4R)-2-methyl-4-phenylpentyl]piperidine
Authors:Tripathi, S.M., Ramachandran, R.
Deposit date:2008-04-04
Release date:2009-06-30
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mutational Analysis of Mycobacterium Tuberculosis Lysine Epsilon-Aminotransferase and Inhibitor Co-Crystal Structures, Reveals Distinct Binding Modes.
Biochem.Biophys.Res.Commun., 463, 2015
2JJH
  • Download 2jjh
  • View 2jjh
Molmil generated image of 2jjh
E243 MUTANT OF M. TUBERCULOSIS RV3290C
Descriptor:L-LYSINE EPSILON AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, 2-OXOGLUTARIC ACID
Authors:Tripathi, S.M., Ramachandran, R.
Deposit date:2008-04-04
Release date:2009-06-30
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mutational Analysis of Mycobacterium Tuberculosis Lysine Epsilon-Aminotransferase and Inhibitor Co-Crystal Structures, Reveals Distinct Binding Modes.
Biochem.Biophys.Res.Commun., 463, 2015
5VGA
  • Download 5vga
  • View 5vga
Molmil generated image of 5vga
ALTERNATIVE MODEL FOR FAB 36-65
Descriptor:Fab 36-65 light chain, Fab 36-65 heavy chain, TRIETHYLENE GLYCOL
Authors:Stanfield, R.L., Rupp, B., Wlodawer, A., Dauter, Z., Porebski, P.J., Minor, W., Jaskolski, M., Pozharski, E., Weichenberger, C.X.
Deposit date:2017-04-10
Release date:2017-12-06
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Detect, correct, retract: How to manage incorrect structural models.
FEBS J., 285, 2018