7T3F

Development of BRD4 inhibitors as arsenicals antidotes

Summary for 7T3F

Entry DOI	10.2210/pdb7t3f/pdb
Descriptor	Bromodomain-containing protein 4, 4-fluoro-3-methyl-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzene-1-sulfonamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	bromodomain-containing protein, dna damage, antidotes, brd4 inhibitors, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15704.05
Authors	Wu, M.,Yatchang, M.,Mathew, B.,Zhai, L.,Ruiz, P.,Bostwick, R.,Augelli-Szafran, C.E.,Suto, M.J. (deposition date: 2021-12-07, release date: 2022-08-31, Last modification date: 2023-10-18)
Primary citation	Yatchang, M.F.,Mathew, B.,Srivastava, R.K.,Khan, J.,Muzaffar, S.,Zhang, S.,Wu, M.,Zhai, L.,Ruiz, P.,Agarwal, A.,Bostwick, J.R.,Suto, M.J.,Athar, M.,Augelli-Szafran, C.E. Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals. Bioorg.Med.Chem.Lett., 64:128696-128696, 2022 Cited by PubMed: 35318165 DOI: 10.1016/j.bmcl.2022.128696 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.28 Å)

Structure validation