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4LAJ
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CRYSTAL STRUCTURE OF HIV-1 YU2 ENVELOPE GP120 GLYCOPROTEIN IN COMPLEX WITH CD4-MIMETIC MINIPROTEIN, M48U1, AND LLAMA SINGLE-DOMAIN, BROADLY NEUTRALIZING, CO-RECEPTOR BINDING SITE ANTIBODY, JM4
分子名称:HIV-1 YU2 gp120 envelope glycoprotein, CD4-mimetic miniprotein M48U1, Llama single domain antibody, ...
著者Acharya, P., Luongo, T.S., Kwong, P.D.
登録日2013-06-20
公開日2013-08-14
最終更新日2014-04-09
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites.
J.Virol., 87, 2013
4JZW
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CRYSTAL STRUCTURE OF CD4-MIMETIC MINIPROTEIN M48U1 IN COMPLEX WITH HIV-1 YU2 GP120 IN P212121 SPACE GROUP
分子名称:HIV-1 YU2 gp120 glycoprotein, CD4-MIMETIC MINIPROTEIN M48U1, N-ACETYL-D-GLUCOSAMINE, ...
著者Acharya, P., Kwong, P.D.
登録日2013-04-03
公開日2013-06-12
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (1.784 Å)
主引用文献Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 A Cocrystal Structure of gp120 and M48U1.
Structure, 21, 2013
4JZZ
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CRYSTAL STRUCTURE OF CD4-MIMETIC MINIPROTEIN M48U1 IN COMPLEX WITH HIV-1 YU2 GP120 IN C2221 SPACE GROUP
分子名称:HIV-1 YU2 gp120 glycoprotein, CD4-MIMETIC MINIPROTEIN M48U1, N-ACETYL-D-GLUCOSAMINE, ...
著者Acharya, P., Kwong, P.D.
登録日2013-04-03
公開日2013-06-12
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 A Cocrystal Structure of gp120 and M48U1.
Structure, 21, 2013
4K0A
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CRYSTAL STRUCTURE OF CD4-MIMETIC MINIPROTEIN M48U7 IN COMPLEX WITH HIV-1 YU2 GP120
分子名称:HIV-1 YU2 gp120 glycoprotein, CD4-MIMETIC MINIPROTEIN M48U7, N-ACETYL-D-GLUCOSAMINE, ...
著者Acharya, P., Kwong, P.D.
登録日2013-04-03
公開日2013-06-12
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 A Cocrystal Structure of gp120 and M48U1.
Structure, 21, 2013
1Y5Y
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STRUCTURE OF THE TETRAHYDROMETHANOPTERIN DEPENDENT FORMALDEHYDE-ACTIVATING ENZYME (FAE) FROM METHYLOBACTERIUM EXTORQUENS AM1
分子名称:Formaldehyde-activating enzyme fae, CALCIUM ION, SODIUM ION
著者Acharya, P., Goenrich, M., Hagemeier, C.H., Demmer, U., Vorholt, J.A., Thauer, R.K., Ermler, U.
登録日2004-12-03
公開日2005-01-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献How an enzyme binds the C1-carrier tetrahydromethanopterin: Structure of the tetrahydromethanopterin dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1
J.Biol.Chem., 280, 2005
1Y60
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STRUCTURE OF THE TETRAHYDROMETHANOPTERIN DEPENDENT FORMALDEHYDE-ACTIVATING ENZYME (FAE) FROM METHYLOBACTERIUM EXTORQUENS AM1 WITH BOUND 5,10-METHYLENE TETRAHYDROMETHANOPTERIN
分子名称:Formaldehyde-activating enzyme fae, 5,10-DIMETHYLENE TETRAHYDROMETHANOPTERIN
著者Acharya, P., Goenrich, M., Hagemeier, C.H., Demmer, U., Vorholt, J.A., Thauer, R.K., Ermler, U.
登録日2004-12-03
公開日2005-01-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献How an enzyme binds the C1-carrier tetrahydromethanopterin: Structure of the tetrahydromethanopterin dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1
J.Biol.Chem., 280, 2005
2FHJ
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CRYSTAL STRUCTURE OF FORMYLMETHANOFURAN: TETRAHYDROMETHANOPTERIN FORMYLTRANSFERASE IN COMPLEX WITH ITS COENZYMES
分子名称:Formylmethanofuran--tetrahydromethanopterin formyltransferase, POTASSIUM ION, N-[4,5,7-TRICARBOXYHEPTANOYL]-L-GAMMA-GLUTAMYL-N-{2-[4-({5-[(FORMYLAMINO)METHYL]-3-FURYL}METHOXY)PHENYL]ETHYL}-D-GLUTAMINE, ...
著者Acharya, P., Warkentin, E., Thauer, R.K., Shima, S., Ermler, U.
登録日2005-12-25
公開日2006-03-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes
J.Mol.Biol., 357, 2006
2FHK
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CRYSTAL STRUCTURE OF FORMYLMETHANOFURAN: TETRAHYDROMETHANOPTERIN FORMYLTRANSFERASE IN COMPLEX WITH ITS COENZYMES
分子名称:Formylmethanofuran--tetrahydromethanopterin formyltransferase, POTASSIUM ION, N-[4,5,7-TRICARBOXYHEPTANOYL]-L-GAMMA-GLUTAMYL-N-{2-[4-({5-[(FORMYLAMINO)METHYL]-3-FURYL}METHOXY)PHENYL]ETHYL}-D-GLUTAMINE
著者Acharya, P., Warkentin, E., Thauer, R.K., Shima, S., Ermler, U.
登録日2005-12-25
公開日2006-03-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes
J.Mol.Biol., 357, 2006
4R4F
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CRYSTAL STRUCTURE OF NON-NEUTRALIZING, A32-LIKE ANTIBODY 2.2C IN COMPLEX WITH HIV-1 YU2 GP120
分子名称:HIV-1 Env gp120, Antibody 2.2c LIGHT CHAIN, Antibody 2.2c heavy CHAIN, ...
著者Acharya, P., Kwong, P.D.
登録日2014-08-19
公開日2014-09-17
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (3.514 Å)
主引用文献Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
4R4N
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CRYSTAL STRUCTURE OF THE ANTI-HIV-1 ANTIBODY 2.2C IN COMPLEX WITH HIV-1 93UG037 GP120
分子名称:HIV-1 gp120, M48U1 peptide, Antibody 2.2c LIGHT CHAIN, ...
著者Acharya, P., Louder, R., Kwong, P.D.
登録日2014-08-19
公開日2014-11-05
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (3.56 Å)
主引用文献Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
5U1F
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INITIAL CONTACT OF HIV-1 ENV WITH CD4: CRYO-EM STRUCTURE OF BG505 DS-SOSIP TRIMER IN COMPLEX WITH CD4 AND ANTIBODY PGT145
分子名称:BG505 DS-SOSIP gp120, BG505 SOSIP gp41, PGT145 heavy chain, ...
著者Acharya, P., Kwong, P.D., Potter, C.S., Carragher, B.
登録日2016-11-28
公開日2017-02-22
最終更新日2018-10-03
実験手法ELECTRON MICROSCOPY (6.8 Å)
主引用文献Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.
Nat. Struct. Mol. Biol., 24, 2017
4KA2
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CRYSTAL STRUCTURE OF CD4-MIMETIC MINIPROTEIN M48U12 IN COMPLEX WITH HIV-1 YU2 GP120
分子名称:HIV-1 YU2 gp120, M48U12, N-ACETYL-D-GLUCOSAMINE
著者Acharya, P., Kwong, P.D.
登録日2013-04-21
公開日2013-06-19
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Interfacial Cavity Filling To Optimize CD4-Mimetic Miniprotein Interactions with HIV-1 Surface Glycoprotein.
J.Med.Chem., 56, 2013
4H8W
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CRYSTAL STRUCTURE OF NON-NEUTRALIZING AND ADCC-POTENT ANTIBODY N5-I5 IN COMPLEX WITH HIV-1 CLADE A/E GP120 AND SCD4.
分子名称:HIV-1 CLADE A/E 93TH057 (H375S) GP120, FAB HEAVY CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5, FAB LIGHT CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5, ...
著者Tolbert, W.D., Acharya, P., Kwong, P.D., Pazgier, M.
登録日2012-09-24
公開日2014-04-09
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
4R4B
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CRYSTAL STRUCTURE OF THE ANTI-HIV-1 ANTIBODY 2.2C
分子名称:FAB 2.2C LIGHT CHAIN, FAB 2.2C HEAVY CHAIN, SULFATE ION, ...
著者McLellan, J.S., Acharya, P., Huang, C.-C., Robinson, J., Kwong, P.D.
登録日2014-08-19
公開日2014-09-10
最終更新日2014-10-22
実験手法X-RAY DIFFRACTION (2.199 Å)
主引用文献Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
4R4H
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CRYSTAL STRUCTURE OF NON-NEUTRALIZING, A32-LIKE ANTIBODY 2.2C IN COMPLEX WITH HIV-1 ENV GP120
分子名称:HIV-1 Env gp120, T-cell surface glycoprotein CD4, Antibody 2.2c, ...
著者Mclellan, J., Acharya, P., Huang, C.-C., Kwong, P.D.
登録日2014-08-19
公開日2014-09-17
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (4.28 Å)
主引用文献Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
4RWY
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CRYSTAL STRUCTURE OF VH1-46 GERMLINE-DERIVED CD4-BINDING SITE-DIRECTED ANTIBODY 8ANC131 IN COMPLEX WITH HIV-1 CLADE B YU2 GP120
分子名称:HIV-1 YU2 gp120, Antibody 8ANC131 Heavy chain, Antibody 8ANC131 Light chain, ...
著者Acharya, P., Luongo, T.S., Kwong, P.D.
登録日2014-12-08
公開日2015-07-01
実験手法X-RAY DIFFRACTION (2.128 Å)
主引用文献Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell(Cambridge,Mass.), 161, 2015
4YFL
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CRYSTAL STRUCTURE OF VH1-46 GERMLINE-DERIVED CD4-BINDING SITE-DIRECTED ANTIBODY 1B2530 IN COMPLEX WITH HIV-1 CLADE A/E 93TH057 GP120
分子名称:Envelope glycoprotein gp160,Envelope glycoprotein gp160,Envelope glycoprotein gp160, 1B2530 heavy chain, 1B2530 Light chain, ...
著者Acharya, P., Zhou, T., Moquin, S., Kwong, P.D.
登録日2015-02-25
公開日2015-06-03
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (3.387 Å)
主引用文献Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015
6CDE
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CRYO-EM STRUCTURE AT 3.8 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP20.01 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
分子名称:vFP20.01 Heavy Chain, vFP20.01 Light chain, PGT122 Heavy chain, ...
著者Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D.
登録日2018-02-08
公開日2018-05-16
最終更新日2018-06-20
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDI
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CRYO-EM STRUCTURE AT 3.6 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP16.02 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
分子名称:Glycoprotein gp41, Glycoprotein 120, PGT122 Light Chain, ...
著者Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D.
登録日2018-02-08
公開日2018-05-16
最終更新日2019-02-20
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CUE
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CRYO-EM STRUCTURE AT 4.0 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP7.04 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
分子名称:Envelope glycoprotein gp120, Envelope glycoprotein gp41, vFP7.04 Heavy chain, ...
著者Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D.
登録日2018-03-26
公開日2018-07-11
最終更新日2018-10-03
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV.
PLoS Pathog., 14, 2018
6CUF
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CRYO-EM STRUCTURE AT 4.2 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP1.01 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
分子名称:vFP1.01 heavy chain, vFP1.01 Light chain, PGT122 Heavy chain, ...
著者Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D.
登録日2018-03-26
公開日2018-07-25
最終更新日2018-10-03
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV.
PLoS Pathog., 14, 2018
6E5P
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BACKBONE MODEL BASED ON CRYO-EM MAP AT 8.5 A OF DOMAIN-SWAPPED, GLYCAN-REACTIVE, NEUTRALIZING ANTIBODY 2G12 BOUND TO HIV-1 ENV BG505 DS-SOSIP, WHICH WAS ALSO BOUND TO CD4-BINDING SITE ANTIBODY VRC03
分子名称:2G12 Light chain, 2G12 heavy chain, Envelope glycoprotein gp120, ...
著者Acharya, P., Kwong, P.D.
登録日2018-07-21
公開日2019-02-13
実験手法ELECTRON MICROSCOPY (8.8 Å)
主引用文献Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition.
Structure, 27, 2019
6MJZ
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CRYO-EM STRUCTURE OF HUMAN PARAINFLUENZA VIRUS TYPE 3 (HPIV3) IN COMPLEX WITH ANTIBODY PIA174
分子名称:Fusion glycoprotein F0, PIA174 Fab Heavy chain, PIA174 Fab Light chain
著者Acharya, P., Stewart-Jones, G., Carragher, B., Potter, C.S., Kwong, P.D.
登録日2018-09-24
公開日2018-11-14
最終更新日2018-12-12
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4JPW
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY 12A21 IN COMPLEX WITH HIV-1 STRAIN 93TH057 GP120 MUTANT
分子名称:HIV-1 CLADE A/E STRAIN 73TH057 GP120 WITH MUTATION H375S, HEAVY CHAIN OF ANTIBODY 12A21, LIGHT CHAIN OF ANTIBODY 12A21, ...
著者Acharya, P., Luongo, T., Zhou, T., Kwong, P.D.
登録日2013-03-19
公開日2013-04-17
最終更新日2013-08-21
実験手法X-RAY DIFFRACTION (2.904 Å)
主引用文献Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.
Cell(Cambridge,Mass.), 153, 2013
4RX4
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CRYSTAL STRUCTURE OF VH1-46 GERMLINE-DERIVED CD4-BINDING SITE-DIRECTED ANTIBODY 8ANC134 IN COMPLEX WITH HIV-1 CLADE A Q842.D12 GP120
分子名称:HIV-1 Clade A Q842.d12 gp120, 8ANC134 Heavy chain, 8ANC134 Light Chain, ...
著者Zhou, T., Acharya, P., Moquin, S., Kwong, P.D.
登録日2014-12-08
公開日2015-07-01
最終更新日2015-07-08
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell(Cambridge,Mass.), 161, 2015
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