Author results

1M1L
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HUMAN SUPPRESSOR OF FUSED (N-TERMINAL DOMAIN)
Descriptor:Suppressor of Fused
Authors:Merchant, M., Vajdos, F.F., Ultsch, M., Maun, H.R., Wendt, U., Cannon, J., Lazarus, R.A., de Vos, A.M., de Sauvage, F.J.
Deposit date:2002-06-19
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Suppressor of fused regulates Gli activity through a dual binding mechanism
Mol.Cell.Biol., 24, 2004
5W96
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SOLUTION STRUCTURE OF PHAGE DERIVED PEPTIDE INHIBITOR OF FRIZZLED 7 RECEPTOR
Descriptor:Fz7 binding peptide
Authors:Nile, A.H., de Sousa e Melo, F., Mukund, S., Piskol, R., Hansen, S., Zhou, L., Zhang, Y., Fu, Y., Gogol, E.B., Komuves, L.G., Modrusan, Z., Angers, S., Franke, Y., Koth, C., Fairbrother, W.J., Wang, W., de Sauvage, F.J., Hannoush, R.N.
Deposit date:2017-06-22
Release date:2018-04-18
Last modified:2018-05-30
Method:SOLUTION NMR
Cite:A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nat. Chem. Biol., 14, 2018
5WBS
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CRYSTAL STRUCTURE OF FRIZZLED-7 CRD WITH AN INHIBITOR PEPTIDE FZ7-21
Descriptor:Frizzled-7,inhibitor peptide Fz7-21
Authors:Nile, A.H., Mukund, S., Hannoush, R.N., Wang, W.
Deposit date:2017-06-29
Release date:2018-04-18
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nat. Chem. Biol., 14, 2018
2HDE
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SOLUTION STRUCTURE OF HUMAN SAP18
Descriptor:Histone deacetylase complex subunit SAP18
Authors:McCallum, S.A., Yin, J.P., Pan, B., Fairbrother, W.J.
Deposit date:2006-06-20
Release date:2007-04-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly.
Biochemistry, 45, 2006
3HO3
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CRYSTAL STRUCTURE OF HEDGEHOG-INTERACTING PROTEIN (HHIP)
Descriptor:Hedgehog-interacting protein
Authors:Bosanac, I., Hymowitz, S.G.
Deposit date:2009-06-01
Release date:2009-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat.Struct.Mol.Biol., 16, 2009
3HO4
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CRYSTAL STRUCTURE OF HEDGEHOG-INTERACTING PROTEIN (HHIP)
Descriptor:Hedgehog-interacting protein
Authors:Hymowitz, S.G., Bosanac, I.
Deposit date:2009-06-01
Release date:2009-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat.Struct.Mol.Biol., 16, 2009
3HO5
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CRYSTAL STRUCTURE OF HEDGEHOG-INTERACTING PROTEIN (HHIP) AND SONIC HEDGEHOG (SHH) COMPLEX
Descriptor:Hedgehog-interacting protein, Sonic hedgehog protein, ZINC ION, ...
Authors:Hymowitz, S.G., Bosanac, I.
Deposit date:2009-06-01
Release date:2009-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat.Struct.Mol.Biol., 16, 2009
3MXV
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CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI-SHH 5E1 CHIMERA
Descriptor:fab fragment of anti-Shh 5E1 mouse/human chimera, light chain, heavy chain, ...
Authors:Hymowitz, S.G., Maun, H.R.
Deposit date:2010-05-07
Release date:2010-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.
J.Biol.Chem., 285, 2010
3MXW
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CRYSTAL STRUCTURE SONIC HEDGEHOG BOUND TO THE 5E1 FAB FRAGMENT
Descriptor:Sonic hedgehog protein, 5E1 light chain, 5E1 heavy chain, ...
Authors:Hymowitz, S.G., Maun, H.R.
Deposit date:2010-05-07
Release date:2010-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.
J.Biol.Chem., 285, 2010
4BLB
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CRYSTAL STRUCTURE OF A HUMAN SUPPRESSOR OF FUSED (SUFU)-GLI1P COMPLEX
Descriptor:MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG, ZINC FINGER PROTEIN GLI1, ...
Authors:Cherry, A.L., Finta, C., Karlstrom, M., De Sanctis, D., Toftgard, R., Jovine, L.
Deposit date:2013-05-02
Release date:2013-11-27
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation
Acta Crystallogr.,Sect.D, 69, 2013
4BLD
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CRYSTAL STRUCTURE OF A HUMAN SUPPRESSOR OF FUSED (SUFU)-GLI3P COMPLEX
Descriptor:MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG, TRANSCRIPTIONAL ACTIVATOR GLI3, ...
Authors:Cherry, A.L., Finta, C., Karlstrom, M., De Sanctis, D., Toftgard, R., Jovine, L.
Deposit date:2013-05-02
Release date:2013-11-27
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation
Acta Crystallogr.,Sect.D, 69, 2013
4BL8
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CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN SUPPRESSOR OF FUSED (SUFU)
Descriptor:MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG, MALTOSE
Authors:Karlstrom, M., Finta, C., Cherry, A.L., Toftgard, R., Jovine, L.
Deposit date:2013-05-02
Release date:2013-11-27
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation
Acta Crystallogr.,Sect.D, 69, 2013
4BL9
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CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN SUPPRESSOR OF FUSED (SUFU) MUTANT LACKING A REGULATORY SUBDOMAIN (CRYSTAL FORM I)
Descriptor:MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG, MALTOSE
Authors:Cherry, A.L., Finta, C., Karlstrom, M., Toftgard, R., Jovine, L.
Deposit date:2013-05-02
Release date:2013-11-27
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation
Acta Crystallogr.,Sect.D, 69, 2013
4BLA
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CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN SUPPRESSOR OF FUSED (SUFU) MUTANT LACKING A REGULATORY SUBDOMAIN (CRYSTAL FORM II)
Descriptor:MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG
Authors:Cherry, A.L., Finta, C., Karlstrom, M., Toftgard, R., Jovine, L.
Deposit date:2013-05-02
Release date:2013-11-27
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation
Acta Crystallogr.,Sect.D, 69, 2013
1GNA
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DETERMINATION OF THE SOLUTION STRUCTURE OF THE PEPTIDE HORMONE GUANYLIN: OBSERVATION OF A NOVEL FORM OF TOPOLOGICAL STEREOISOMERISM
Descriptor:GUANYLIN PRECURSOR
Authors:Skelton, N.J., Garcia, K.C.
Deposit date:1994-06-30
Release date:1994-09-30
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism.
Biochemistry, 33, 1994
1GNB
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DETERMINATION OF THE SOLUTION STRUCTURE OF THE PEPTIDE HORMONE GUANYLIN: OBSERVATION OF A NOVEL FORM OF TOPOLOGICAL STEREOISOMERISM
Descriptor:GUANYLIN PRECURSOR
Authors:Skelton, N.J., Garcia, K.C.
Deposit date:1994-06-30
Release date:1994-09-30
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism.
Biochemistry, 33, 1994