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1F0K
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THE 1.9 ANGSTROM CRYSTAL STRUCTURE OF E. COLI MURG
Descriptor:UDP-N-ACETYLGLUCOSAMINE-N-ACETYLMURAMYL-(PENTAPEPTIDE) PYROPHOSPHORYL-UNDECAPRENOL N-ACETYLGLUCOSAMINE TRANSFERASE, SULFATE ION
Authors:Ha, S., Walker, D., Shi, Y., Walker, S.
Deposit date:2000-05-16
Release date:2000-07-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The 1.9 A crystal structure of Escherichia coli MurG, a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis.
Protein Sci., 9, 2000
1NLM
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CRYSTAL STRUCTURE OF MURG:GLCNAC COMPLEX
Descriptor:UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, GLYCEROL
Authors:Hu, Y., Chen, L., Ha, S., Gross, B., Falcone, B., Walker, D., Mokhtarzadeh, M., Walker, S.
Deposit date:2003-01-07
Release date:2003-02-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases
Proc.Natl.Acad.Sci.USA, 100, 2003
3NB7
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CRYSTAL STRUCTURE OF AQUIFEX AEOLICUS PEPTIDOGLYCAN GLYCOSYLTRANSFERASE IN COMPLEX WITH DECARBOXYLATED NERYL MOENOMYCIN
Descriptor:Penicillin-binding protein 1A
Authors:Sliz, P., Yuan, Y., Walker, S.
Deposit date:2010-06-02
Release date:2011-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Functional and structural analysis of a key region of the cell wall inhibitor moenomycin.
Acs Chem.Biol., 5, 2010
3D3H
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CRYSTAL STRUCTURE OF A COMPLEX OF THE PEPTIDOGLYCAN GLYCOSYLTRANSFERASE DOMAIN FROM AQUIFEX AEOLICUS AND NERYL MOENOMYCIN A
Descriptor:Penicillin-insensitive transglycosylase, (2R)-3-{[(S)-{[(2R,3R,4R,5S,6S)-3-{[(2S,3R,4R,5S,6R)-3-(acetylamino)-5-{[(2S,3R,4R,5S,6R)-3-(acetylamino)-5-{[(2R,3R,4S,5R,6S)-6-carbamoyl-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]oxy}-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4-hydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-6-carbamoyl-4-(carbamoyloxy)-5-hydroxy-5-methyltetrahydro-2H-pyran-2-yl]oxy}(hydroxy)phosphoryl]oxy}-2-{[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]oxy}propanoic acid
Authors:Yuan, Y., Sliz, P., Walker, S.
Deposit date:2008-05-11
Release date:2008-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design.
Acs Chem.Biol., 3, 2008
3NB6
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CRYSTAL STRUCTURE OF AQUIFEX AEOLICUS PEPTIDOGLYCAN GLYCOSYLTRANSFERASE IN COMPLEX WITH METHYLPHOSPHORYL NERYL MOENOMYCIN
Descriptor:Penicillin-binding protein 1A
Authors:Sliz, P., Yuan, Y., Walker, S., Kahne, D.
Deposit date:2010-06-02
Release date:2011-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Functional and structural analysis of a key region of the cell wall inhibitor moenomycin.
Acs Chem.Biol., 5, 2010
5DKP
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CRYSTAL STRUCTURE OF N. MENINGITIDIS CLPP IN COMPLEX WITH AGONIST ADEP A54556.
Descriptor:ATP-dependent Clp protease proteolytic subunit, agonist ADEP A54556, POTASSIUM ION, ...
Authors:Goodreid, J.D., Janetzko, J., Santa Maria Jr., J.P., Wong, K., Leung, E., Eger, B.T., Bryson, S., Pai, E.F., Gray-Owen, S.D., Walker, S., Houry, W.A., Batey, R.A.
Deposit date:2015-09-03
Release date:2016-01-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.381 Å)
Cite:Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity.
J.Med.Chem., 59, 2016
1FQZ
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NMR VALIDATED MODEL OF DOMAIN IIID OF HEPATITIS C VIRUS INTERNAL RIBOSOME ENTRY SITE
Descriptor:HEPATITIS C VIRUS IRES DOMAIN IIID
Authors:Klinck, R., Westhof, E., Walker, S., Afshar, M., Collier, A., Aboul-ela, F.
Deposit date:2000-09-07
Release date:2001-01-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A potential RNA drug target in the hepatitis C virus internal ribosomal entry site.
RNA, 6, 2000
1KP7
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CONSERVED RNA STRUCTURE WITHIN THE HCV IRES EIF3 BINDING SITE
Descriptor:Hepatitis C Virus Internal Ribosome Entry Site Fragment
Authors:Gallego, J., Klinck, R., Collier, A.J., Cole, P.T., Harris, S.J., Harrison, G.P., Aboul-ela, F., Walker, S., Varani, G.
Deposit date:2001-12-29
Release date:2002-04-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A conserved RNA structure within the HCV IRES eIF3-binding site.
Nat.Struct.Biol., 9, 2002
2OQO
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CRYSTAL STRUCTURE OF A PEPTIDOGLYCAN GLYCOSYLTRANSFERASE FROM A CLASS A PBP: INSIGHT INTO BACTERIAL CELL WALL SYNTHESIS
Descriptor:Penicillin-binding protein 1A (PBP-1a) (PBP1a), 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE
Authors:Yuan, Y., Sliz, P., Walker, S.
Deposit date:2007-01-31
Release date:2007-03-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3PE3
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STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE AND ITS COMPLEX WITH A PEPTIDE SUBSTRATE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, URIDINE-5'-DIPHOSPHATE
Authors:Lazarus, M.B., Nam, Y., Jiang, J., Sliz, P., Walker, S.
Deposit date:2010-10-25
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Structure of human O-GlcNAc transferase and its complex with a peptide substrate.
Nature, 469, 2011
3PE4
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STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE AND ITS COMPLEX WITH A PEPTIDE SUBSTRATE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lazarus, M.B., Nam, Y., Jiang, J., Sliz, P., Walker, S.
Deposit date:2010-10-25
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of human O-GlcNAc transferase and its complex with a peptide substrate.
Nature, 469, 2011
3TAX
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A NEUTRAL DIPHOSPHATE MIMIC CROSSLINKS THE ACTIVE SITE OF HUMAN O-GLCNAC TRANSFERASE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lazarus, M.B., Jiang, J., Pasquina, L., Sliz, P., Walker, S.
Deposit date:2011-08-04
Release date:2011-11-16
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2011
4GYW
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE IN COMPLEX WITH UDP AND A GLYCOPEPTIDE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-05
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GYY
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP-5SGLCNAC AND A PEPTIDE SUBSTRATE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ...
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-05
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GZ3
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP AND A THIOGLYCOPEPTIDE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-05
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GZ5
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP-GLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, SULFATE ION
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-06
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3.075 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4GZ6
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE WITH UDP-5SGLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, SULFATE ION
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-06
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
4N39
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE BOUND TO A PEPTIDE FROM HCF-1 PRO-REPEAT 2 (11-26)
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host cell factor 1, URIDINE-5'-DIPHOSPHATE
Authors:Lazarus, M.B., Herr, W., Walker, S.
Deposit date:2013-10-06
Release date:2014-01-01
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Science, 342, 2013
4N3A
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE BOUND TO A PEPTIDE FROM HCF-1 PRO-REPEAT 2 (1-26)E10A
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host cell factor 1, URIDINE-5'-DIPHOSPHATE
Authors:Lazarus, M.B., Herr, W., Walker, S.
Deposit date:2013-10-06
Release date:2014-01-01
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Science, 342, 2013
4N3B
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE BOUND TO A PEPTIDE FROM HCF-1 PRO-REPEAT2(1-26)E10Q AND UDP-5SGLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host cell factor 1, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Lazarus, M.B., Herr, W., Walker, S.
Deposit date:2013-10-06
Release date:2014-01-01
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Science, 342, 2013
4N3C
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE BOUND TO A PEPTIDE FROM HCF-1 PRO-REPEAT2(1-26) AND UDP-GLCNAC
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host cell factor 1, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE
Authors:Lazarus, M.B., Herr, W., Walker, S.
Deposit date:2013-10-06
Release date:2014-01-01
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Science, 342, 2013
4P31
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CRYSTAL STRUCTURE OF A SELENOMETHIONINE DERIVATIVE OF E. COLI LPTB IN COMPLEX WITH ADP-MAGENSIUM
Descriptor:Lipopolysaccharide export system ATP-binding protein LptB, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Sherman, D.J., Lazarus, M.B., Murphy, L., Liu, C., Walker, S., Ruiz, N., Kahne, D.
Deposit date:2014-03-05
Release date:2014-03-26
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport.
Proc.Natl.Acad.Sci.USA, 111, 2014
4P32
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CRYSTAL STRUCTURE OF E. COLI LPTB IN COMPLEX WITH ADP-MAGNESIUM
Descriptor:Lipopolysaccharide export system ATP-binding protein LptB, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Sherman, D.J., Lazarus, M.B., Murphy, L., Liu, C., Walker, S., Ruiz, N., Kahne, D.
Deposit date:2014-03-05
Release date:2014-03-26
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport.
Proc.Natl.Acad.Sci.USA, 111, 2014
4P33
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CRYSTAL STRUCTURE OF E. COLI LPTB-E163Q IN COMPLEX WITH ATP-SODIUM
Descriptor:Lipopolysaccharide export system ATP-binding protein LptB, SODIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Sherman, D.J., Lazarus, M.B., Murphy, L., Liu, C., Walker, S., Ruiz, N., Kahne, D.
Deposit date:2014-03-05
Release date:2014-03-26
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport.
Proc.Natl.Acad.Sci.USA, 111, 2014
5HGV
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STRUCTURE OF AN O-GLCNAC TRANSFERASE POINT MUTANT, D554N IN COMPLEX WITH PEPTIDE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, TYR-PRO-GLY-GLY-SER-THR-PRO-VAL-SER-SER-ALA-ASN-MET-MET, URIDINE-5'-DIPHOSPHATE, ...
Authors:Janetzko, J., Lazarus, M.B., Walker, S.
Deposit date:2016-01-08
Release date:2016-09-14
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:How the glycosyltransferase OGT catalyzes amide bond cleavage.
Nat.Chem.Biol., 12, 2016
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