4N39

Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26)

Summary for 4N39

Entry DOI	10.2210/pdb4n39/pdb
Related	4N3A 4N3B 4N3C
Descriptor	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host cell factor 1, URIDINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	glycosyltransferase, o-glcnac transferase, proteolysis substrate, tpr domain, tpr binding, transferase-substrate complex, transferase/substrate
Biological source	Homo sapiens (human) More
Cellular location	Isoform 2: Mitochondrion. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm: O15294 Cytoplasm: P51610
Total number of polymer chains	2
Total formula weight	82987.27
Authors	Lazarus, M.B.,Herr, W.,Walker, S. (deposition date: 2013-10-06, release date: 2014-01-01, Last modification date: 2024-02-28)
Primary citation	Lazarus, M.B.,Jiang, J.,Kapuria, V.,Bhuiyan, T.,Janetzko, J.,Zandberg, W.F.,Vocadlo, D.J.,Herr, W.,Walker, S. HCF-1 is cleaved in the active site of O-GlcNAc transferase. Science, 342:1235-1239, 2013 Cited by PubMed: 24311690 DOI: 10.1126/science.1243990 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation