Author results

1MN6
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THIOESTERASE DOMAIN FROM PICROMYCIN POLYKETIDE SYNTHASE, PH 7.6
Descriptor:polyketide synthase IV
Authors:Tsai, S.-C., Lu, H., Cane, D.E., Khosla, C., Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MNA
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THIOESTERASE DOMAIN OF PICROMYCIN POLYKETIDE SYNTHASE (PICS TE), PH 8.0
Descriptor:polyketide synthase IV
Authors:Tsai, S.-C., Lu, H., Cane, D.E., Khosla, C., Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MNQ
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THIOESTERASE DOMAIN OF PICROMYCIN POLYKETIDE SYNTHASE (PICS TE), PH 8.4
Descriptor:polyketide synthase IV
Authors:Tsai, S.-C., Lu, H., Cane, D.E., Khosla, C., Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MO2
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THIOESTERASE DOMAIN FROM 6-DEOXYERYTHRONOLIDE SYNTHASE (DEBS TE), PH 8.5
Descriptor:Erythronolide synthase, modules 5 and 6
Authors:Tsai, S.-C., Lu, H., Cane, D.E., Khosla, C., Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
4X4J
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STRUCTURAL AND FUNCTIONAL STUDIES OF BEXE: INSIGHTS INTO OXIDATION DURING BE-7585A BIOSYNTHESIS
Descriptor:Putative oxygenase, SULFATE ION, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Tsai, S.-C., Jackson, D.R., Patel, A., Barajas, J.F., Rohr, J., Yu, X., Liu, H.-W., Sasaki, E., Calveras, J., Metsa-Ketela, M.
Deposit date:2014-12-02
Release date:2015-12-02
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis
To Be Published
3BB8
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E1 DEHYDRASE H220K MUTANT
Descriptor:CDP-4-keto-6-deoxy-D-glucose-3-dehydrase, PYRIDOXAL-5'-PHOSPHATE, BENZAMIDINE
Authors:Tsai, S.-C., Smith, P.
Deposit date:2007-11-09
Release date:2008-09-16
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:E1 Dehydrase H220K Mutant
To be Published
3BCX
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E1 DEHYDRASE
Descriptor:CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase, FE (III) ION, BENZAMIDINE
Authors:Tsai, S.-C., Smith, P.
Deposit date:2007-11-13
Release date:2007-11-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:E1 Dehydrase.
To be Published
1R2J
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FKBI FOR BIOSYNTHESIS OF METHOXYMALONYL EXTENDER UNIT OF FK520 POLYKETIDE IMMUNOSUPPRESANT
Descriptor:protein FkbI, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Watanabe, K., Khosla, C., Stroud, R.M., Tsai, S.-C.
Deposit date:2003-09-28
Release date:2003-11-25
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of an Acyl-ACP Dehydrogenase from the FK520 Polyketide Biosynthetic Pathway: Insights into Extender Unit Biosynthesis
J.Mol.Biol., 334, 2003
1XNV
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ACYL-COA CARBOXYLASE BETA SUBUNIT FROM S. COELICOLOR (PCCB), APO FORM #1
Descriptor:propionyl-CoA carboxylase complex B subunit
Authors:Diacovich, L., Mitchell, D.L., Pham, H., Gago, G., Melgar, M.M., Khosla, C., Gramajo, H., Tsai, S.-C.
Deposit date:2004-10-05
Release date:2004-11-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
1XNW
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ACYL-COA CARBOXYLASE BETA SUBUNIT FROM S. COELICOLOR (PCCB), APO FORM #2, MUTANT D422I
Descriptor:propionyl-CoA carboxylase complex B subunit
Authors:Diacovich, L., Mitchell, D.L., Pham, H., Gago, G., Melgar, M.M., Khosla, C., Gramajo, H., Tsai, S.-C.
Deposit date:2004-10-05
Release date:2004-11-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
1XNY
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BIOTIN AND PROPIONYL-COA BOUND TO ACYL-COA CARBOXYLASE BETA SUBUNIT FROM S. COELICOLOR (PCCB)
Descriptor:propionyl-CoA carboxylase complex B subunit, propionyl Coenzyme A, BIOTIN
Authors:Diacovich, L., Mitchell, D.L., Pham, H., Gago, G., Melgar, M.M., Khosla, C., Gramajo, H., Tsai, S.-C.
Deposit date:2004-10-05
Release date:2004-11-09
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
1XO6
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ACYL-COA CARBOXYLASE BETA SUBUNIT FROM S. COELICOLOR (PCCB), APO FORM #3
Descriptor:propionyl-CoA carboxylase complex B subunit
Authors:Diacovich, L., Mitchell, D.L., Pham, H., Gago, G., Melgar, M.M., Khosla, C., Gramajo, H., Tsai, S.-C.
Deposit date:2004-10-05
Release date:2004-11-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
2RH4
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ACTINORHODIN KETOREDUCTASE, ACTKR, WITH NADPH AND INHIBITOR EMODIN
Descriptor:Actinorhodin Polyketide Ketoreductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE
Authors:Korman, T.P., Tsai, S.-C.
Deposit date:2007-10-05
Release date:2008-08-19
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase
Biochemistry, 47, 2008
2RHC
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ACTINORHODIN KETORDEUCTASE, ACTKR, WITH NADP+ AND INHIBITOR EMODIN
Descriptor:Actinorhodin Polyketide Ketoreductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE
Authors:Korman, T.P., Tsai, S.-C.
Deposit date:2007-10-08
Release date:2008-08-19
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase
Biochemistry, 47, 2008
2RHR
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P94L ACTINORHODIN KETORDEUCTASE MUTANT, WITH NADPH AND INHIBITOR EMODIN
Descriptor:Actinorhodin Polyketide Ketoreductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE
Authors:Korman, T.P., Tsai, S.-C.
Deposit date:2007-10-09
Release date:2008-08-19
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase
Biochemistry, 47, 2008
3GQV
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LOVASTATIN POLYKETIDE ENOYL REDUCTASE (LOVC) MUTANT K54S WITH BOUND NADP
Descriptor:Enoyl reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL
Authors:Ames, B.D., Smith, P.T., Ma, S.M., Kaake, R., Wong, E.W., Wong, S.K., Xie, X., Li, J.W., Vederas, J.C., Tang, Y., Tsai, S.-C.
Deposit date:2009-03-24
Release date:2009-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:biosynthesis of Lovastatin: Crystal structure and biochemical studies of LOVC, A trans-acting polyketide enoyl reductase
To be Published
1KEZ
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CRYSTAL STRUCTURE OF THE MACROCYCLE-FORMING THIOESTERASE DOMAIN OF ERYTHROMYCIN POLYKETIDE SYNTHASE (DEBS TE)
Descriptor:ERYTHRONOLIDE SYNTHASE
Authors:Tsai, S.-C., Miercke, L.J.W., Krucinski, J., Gokhale, R., Chen, J.C.-H., Foster, P.G., Cane, D.E., Khosla, C., Stroud, R.M.
Deposit date:2001-11-19
Release date:2002-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.
Proc.Natl.Acad.Sci.USA, 98, 2001
3B6Z
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LOVASTATIN POLYKETIDE ENOYL REDUCTASE (LOVC) COMPLEXED WITH 2'-PHOSPHOADENOSYL ISOMER OF CROTONOYL-COA
Descriptor:Enoyl reductase, S-{(9R,13R,15S)-17-[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]-9,13,15-trihydroxy-10,10-dimethyl-13,15-dioxido-4,8-dioxo-12,14,16-trioxa-3,7-diaza-13,15-diphosphaheptadec-1-yl}(2E)-but-2-enethioate, GLYCEROL
Authors:Ames, B.D., Smith, P.T., Ma, S.M., Wong, E.W., Xie, X., Vederas, J.C., Tang, Y., Tsai, S.-C.
Deposit date:2007-10-29
Release date:2008-09-16
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
3B70
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CRYSTAL STRUCTURE OF ASPERGILLUS TERREUS TRANS-ACTING LOVASTATIN POLYKETIDE ENOYL REDUCTASE (LOVC) WITH BOUND NADP
Descriptor:Enoyl reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL
Authors:Ames, B.D., Smith, P.T., Ma, S.M., Wong, E.W., Xie, X., Vederas, J.C., Tang, Y., Tsai, S.-C.
Deposit date:2007-10-29
Release date:2008-09-16
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
3HF1
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CRYSTAL STRUCTURE OF HUMAN P53R2
Descriptor:Ribonucleoside-diphosphate reductase subunit M2 B, FE (III) ION, SULFATE ION
Authors:Smith, P., Zhou, B., Yuan, Y.-C., Su, L., Tsai, S.-C., Yen, Y.
Deposit date:2009-05-10
Release date:2009-10-13
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:2.6 A X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase .
Biochemistry, 48, 2009
3QRW
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ACTINORHODIN POLYKETIDE KETOREDUCTASE MUTANT P94L BOUND TO NADPH
Descriptor:ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, FORMIC ACID
Authors:Korman, T.P., Javidpour, P., Tsai, S.-C.
Deposit date:2011-02-18
Release date:2011-05-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.792 Å)
Cite:Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase.
Biochemistry, 50, 2011
3RI3
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ACTINORHODIN POLYKETIDE KETOREDUCTASE MUTANT P94L BOUND TO NADPH AND THE INHIBITOR EMODIN
Descriptor:ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE
Authors:Javidpour, P., Tsai, S.-C.
Deposit date:2011-04-12
Release date:2011-06-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.292 Å)
Cite:Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase.
Biochemistry, 50, 2011
3SJU
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HEDAMYCIN POLYKETIDE KETOREDUCTASE BOUND TO NADPH
Descriptor:Keto reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Javidpour, P., Tsai, S.-C.
Deposit date:2011-06-21
Release date:2011-09-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase (HedKR): Molecular Basis of Stereo- and Regiospecificities.
Biochemistry, 50, 2011
3TL1
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CRYSTAL STRUCTURE OF THE STREPTOMYCES COELICOLOR WHIE ORFVI POLYKETIDE AROMATASE/CYCLASE
Descriptor:Polyketide cyclase, 6,7,9-trihydroxy-3-methyl-1H-benzo[g]isochromen-1-one, GLYCEROL
Authors:Lee, M.-Y., Ames, B.D., Zhang, W., Tang, Y., Tsai, S.-C.
Deposit date:2011-08-29
Release date:2012-04-04
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVI.
Biochemistry, 51, 2012
3TVQ
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CRYSTAL STRUCTURE OF TCM ARO/CYC COMPLEXED WITH TRANS-DIHIDROQUERCETIN
Descriptor:Multifunctional cyclase-dehydratase-3-O-methyl transferase tcmN, (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE
Authors:Ames, B.D., Lee, M.-Y., Tsai, S.-C.
Deposit date:2011-09-20
Release date:2012-04-04
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Insight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVI.
Biochemistry, 51, 2012
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