Author results

1FZD
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STRUCTURE OF RECOMBINANT ALPHAEC DOMAIN FROM HUMAN FIBRINOGEN-420
Descriptor:FIBRINOGEN-420, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Spraggon, G., Applegate, D., Everse, S.J., Zhang, J.-Z., Veerapandian, L., Redman, C., Doolittle, R.F., Grieninger, G.
Deposit date:1998-06-22
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of a recombinant alphaEC domain from human fibrinogen-420.
Proc.Natl.Acad.Sci.USA, 95, 1998
1FZA
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CRYSTAL STRUCTURE OF FIBRINOGEN FRAGMENT D
Descriptor:FIBRINOGEN, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION
Authors:Spraggon, G., Everse, S.J., Doolittle, R.F.
Deposit date:1997-08-05
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.
Nature, 389, 1997
1FZB
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CRYSTAL STRUCTURE OF CROSSLINKED FRAGMENT D
Descriptor:FIBRINOGEN, PEPTIDE LIGAND GPRG, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Spraggon, G., Everse, S.J., Doolittle, R.F.
Deposit date:1997-08-05
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.
Nature, 389, 1997
1I7Q
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ANTHRANILATE SYNTHASE FROM S. MARCESCENS
Descriptor:ANTHRANILATE SYNTHASE, TRPG, MAGNESIUM ION, ...
Authors:Spraggon, G., Kim, C., Nguyen-Huu, X., Yee, M.-C., Yanofsky, C., Mills, S.E.
Deposit date:2001-03-10
Release date:2001-05-16
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan.
Proc.Natl.Acad.Sci.USA, 98, 2001
1I7S
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ANTHRANILATE SYNTHASE FROM SERRATIA MARCESCENS IN COMPLEX WITH ITS END PRODUCT INHIBITOR L-TRYPTOPHAN
Descriptor:ANTHRANILATE SYNTHASE, TRPG, TRYPTOPHAN
Authors:Spraggon, G., Kim, C., Nguyen-Huu, X., Yee, M.-C., Yanofsky, C., Mills, S.E.
Deposit date:2001-03-10
Release date:2001-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan.
Proc.Natl.Acad.Sci.USA, 98, 2001
1QQR
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CRYSTAL STRUCTURE OF STREPTOKINASE DOMAIN B
Descriptor:STREPTOKINASE DOMAIN B
Authors:Spraggon, G., Zhang, X.X., Ponting, C.P., Fox, V.F., Phillips, C., Smith, R.A.G., Jones, E.Y., Dobson, C., Stuart, D.I.
Deposit date:1999-06-07
Release date:1999-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Streptokinse Domain B
To be Published
1SJ5
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CRYSTAL STRUCTURE OF A DUF151 FAMILY PROTEIN (TM0160) FROM THERMOTOGA MARITIMA AT 2.8 A RESOLUTION
Descriptor:conserved hypothetical protein TM0160
Authors:Spraggon, G., Panatazatos, D., Klock, H.E., Wilson, I.A., Woods Jr., V.L., Lesley, S.A., Joint Center for Structural Genomics (JCSG)
Deposit date:2004-03-02
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171.
Protein Sci., 13, 2004
2X9W
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STRUCTURE OF THE PILUS BACKBONE (RRGB) FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:CELL WALL SURFACE ANCHOR FAMILY PROTEIN, GLYCEROL
Authors:Spraggon, G., Koesema, E., Scarselli, M., Malito, E., Biagini, M., Norais, N., Emolo, C., Barocchi, M.A., Giusti, F., Hilleringmann, M., Rappuoli, R., Lesley, S., Covacci, A., Masignani, V., Ferlenghi, I.
Deposit date:2010-03-25
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Supramolecular Organization of the Repetitive Backbone Unit of the Streptococcus Pneumoniae Pilus.
Plos One, 5, 2010
2X9X
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STRUCTURE OF THE PILUS BACKBONE (RRGB) FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:CELL WALL SURFACE ANCHOR FAMILY PROTEIN, IMIDAZOLE, SODIUM ION
Authors:Spraggon, G., Koesema, E., Scarselli, M., Malito, E., Biagini, M., Norais, N., Emolo, C., Barocchi, M.A., Giusti, F., Hilleringmann, M., Rappuoli, R., Lesley, S., Covacci, A., Masignani, V., Ferlenghi, I.
Deposit date:2010-03-25
Release date:2010-06-30
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Supramolecular Organization of the Repetitive Backbone Unit of the Streptococcus Pneumoniae Pilus.
Plos One, 5, 2010
2X9Y
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STRUCTURE OF THE PILUS BACKBONE (RRGB) FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:CELL WALL SURFACE ANCHOR FAMILY PROTEIN
Authors:Spraggon, G., Koesema, E., Scarselli, M., Malito, E., Biagini, M., Norais, N., Emolo, C., Barocchi, M.A., Giusti, F., Hilleringmann, M., Rappuoli, R., Lesley, S., Covacci, A., Masignani, V., Ferlenghi, I.
Deposit date:2010-03-25
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Supramolecular Organization of the Repetitive Backbone Unit of the Streptococcus Pneumoniae Pilus.
Plos One, 5, 2010
2X9Z
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STRUCTURE OF THE PILUS BACKBONE (RRGB) FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:CELL WALL SURFACE ANCHOR FAMILY PROTEIN
Authors:Spraggon, G., Koesema, E., Scarselli, M., Malito, E., Biagini, M., Norais, N., Emolo, C., Barocchi, M.A., Giusti, F., Hilleringmann, M., Rappuoli, R., Lesley, S., Covacci, A., Masignani, V., Ferlenghi, I.
Deposit date:2010-03-25
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Supramolecular Organization of the Repetitive Backbone Unit of the Streptococcus Pneumoniae Pilus.
Plos One, 5, 2010
3E0N
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THE X-RAY STRUCTURE OF HUMAN PROSTASIN IN COMPLEX WITH DFFR-CHLOROMETHYL KETONE INHIBITOR
Descriptor:Prostasin, SULFATE ION, D-PHENYLALANINE, ...
Authors:Spraggon, G., Hornsby, M., Shipway, A., Harris, J.L., Lesley, S.A.
Deposit date:2008-07-31
Release date:2009-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
3E1X
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THE CRYSTAL STRUCTURE OF APO PROSTASIN AT 1.7 ANGSTROMS RESOLUTION
Descriptor:Prostasin, GLYCEROL
Authors:Spraggon, G., Hornsby, M., Shipway, A., Harris, J.L., Lesley, S.A.
Deposit date:2008-08-04
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
3FVF
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THE CRYSTAL STRUCTURE OF PROSTASIN COMPLEXED WITH CAMOSTAT AT 1.6 ANGSTROMS RESOLUTION
Descriptor:Prostasin, GLYCEROL, 1-[4-(hydroxymethyl)phenyl]guanidine, ...
Authors:Spraggon, G., Hornsby, M., Shipway, A., Harris, J.L., Lesley, S.A.
Deposit date:2009-01-15
Release date:2009-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
3GYL
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STRUCTURE OF PROSTASIN AT 1.3 ANGSTROMS RESOLUTION IN COMPLEX WITH A CALCIUM ION.
Descriptor:Prostasin, CALCIUM ION, GLYCEROL
Authors:Spraggon, G., Hornsby, M., Shipway, A., Harris, J.L., Lesley, S.A.
Deposit date:2009-04-03
Release date:2009-04-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
3GYM
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STRUCTURE OF PROSTASIN IN COMPLEX WITH APROTININ
Descriptor:Prostasin, Pancreatic trypsin inhibitor
Authors:Spraggon, G., Hornsby, M., Shipway, A., Harris, J.L., Lesley, S.A.
Deposit date:2009-04-03
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
2HH5
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CRYSTAL STRUCTURE OF CATHEPSIN S IN COMPLEX WITH A ZINC MEDIATED NON-COVALENT ARYLAMINOETHYL AMIDE
Descriptor:Cathepsin S, ZINC ION, CHLORIDE ION, ...
Authors:Spraggon, G., Hornsby, M., Lesley, S.A., Tully, D.C., Harris, J.L., Karenewsky, D.S.
Deposit date:2006-06-27
Release date:2006-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers.
Bioorg.Med.Chem.Lett., 16, 2006
4E9L
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FDEC, A NOVEL BROADLY CONSERVED ESCHERICHIA COLI ADHESIN ELICITING PROTECTION AGAINST URINARY TRACT INFECTIONS
Descriptor:Attaching and effacing protein, pathogenesis factor
Authors:Spraggon, G., Nesta, B., Alteri, C., Gomes Moriel, D., Rosini, R., Veggi, D., Smith, S., Bertoldi, I., Pastorello, I., Ferlenghi, I., Fontana, M.R., Frankel, G., Mobley, H.L.T., Rappuoli, R., Pizza, M., Serino, L., Soriana, M.
Deposit date:2012-03-21
Release date:2012-04-25
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:FdeC, a novel broadly conserved Escherichia coli adhesin eliciting protection against urinary tract infections.
MBio, 3, 2012
3M0C
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THE X-RAY CRYSTAL STRUCTURE OF PCSK9 IN COMPLEX WITH THE LDL RECEPTOR
Descriptor:Proprotein convertase subtilisin/kexin type 9, Low-density lipoprotein receptor, CALCIUM ION
Authors:Spraggon, G., Hampton, E.N.
Deposit date:2010-03-02
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (7.01 Å)
Cite:The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor
To be Published
1T6H
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CRYSTAL STRUCTURE T4 LYSOZYME INCORPORATING AN UNNATURAL AMINO ACID P-IODO-L-PHENYLALANINE AT POSITION 153
Descriptor:Lysozyme, CHLORIDE ION, BETA-MERCAPTOETHANOL
Authors:Spraggon, G., Xie, J., Wang, L., Wu, N., Brock, A., Schultz, P.G.
Deposit date:2004-05-06
Release date:2004-10-26
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination.
Nat.Biotechnol., 22, 2004
2F1G
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CATHEPSIN S IN COMPLEX WITH NON-COVALENT 2-(BENZOXAZOL-2-YLAMINO)-ACETAMIDE
Descriptor:Cathepsin S, N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE, GLYCEROL
Authors:Spraggon, G., Hornsby, M., Lesley, S.A., Tully, D.C., Harris, J.L., Karenewsky, D.S., Kulathila, R., Clark, K.
Deposit date:2005-11-14
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: Heterocyclic P3.
Bioorg.Med.Chem.Lett., 16, 2006
2HHN
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CATHEPSIN S IN COMPLEX WITH NON COVALENT ARYLAMINOETHYL AMIDE.
Descriptor:Cathepsin S, SULFATE ION, N-[(1R)-1-[(BENZYLSULFONYL)METHYL]-2-{[(1S)-1-METHYL-2-{[4-(TRIFLUOROMETHOXY)PHENYL]AMINO}ETHYL]AMINO}-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE
Authors:Spraggon, G., Hornsby, M., Lesley, S.A., Tully, D.C., Harris, J.L., Karenewsky, D.S., Kulathila, R., Clark, K.
Deposit date:2006-06-28
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers
Bioorg.Med.Chem.Lett., 16, 2006
2OP3
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THE STRUCTURE OF CATHEPSIN S WITH A NOVEL 2-ARYLPHENOXYACETALDEHYDE INHIBITOR DERIVED BY THE SUBSTRATE ACTIVITY SCREENING (SAS) METHOD
Descriptor:Cathepsin S, SULFATE ION, 2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL, ...
Authors:Spraggon, G., Inagaki, H., Tsuruoka, H., Hornsby, M., Lesley, S.A., Ellman, J.A.
Deposit date:2007-01-26
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode.
J.Med.Chem., 50, 2007
3E0P
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THE X-RAY STRUCTURE OF HUMAN PROSTASIN IN COMPLEX WITH A COVALENT BENZOXAZOLE INHIBITOR
Descriptor:Prostasin, benzyl [(1R)-1-({(2S,4R)-2-({(1S)-5-amino-1-[(S)-1,3-benzoxazol-2-yl(hydroxy)methyl]pentyl}carbamoyl)-4-[(4-methylbenzyl)oxy]pyrrolidin-1-yl}carbonyl)-3-phenylpropyl]carbamate, GLYCEROL
Authors:Spraggon, G., Hornsby, M., Shipway, A., Harris, J.L., Lesley, S.A.
Deposit date:2008-07-31
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.
Bioorg.Med.Chem.Lett., 18, 2008
3E16
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X-RAY STRUCTURE OF HUMAN PROSTASIN IN COMPLEX WITH BENZOXAZOLE WARHEAD PEPTIDOMIMIC, LYSINE IN P3
Descriptor:Prostasin, GLYCEROL, benzyl [(1S)-5-amino-1-{[(1S)-1-({(1S)-5-amino-1-[(S)-1,3-benzoxazol-2-yl(hydroxy)methyl]pentyl}carbamoyl)-3-phenylpropyl]carbamoyl}pentyl]carbamate, ...
Authors:Spraggon, G., Hornsby, M., Shipway, A., Harris, J.L., Lesley, S.A.
Deposit date:2008-08-01
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.
Bioorg.Med.Chem.Lett., 18, 2008