3GYL

Structure of Prostasin at 1.3 Angstroms resolution in complex with a Calcium Ion.

Summary for 3GYL

Entry DOI	10.2210/pdb3gyl/pdb
Related	3E1X 3EON 3FVF
Descriptor	Prostasin, CALCIUM ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	prostasin, enac, zymogen, divalent cation, channel activating, cell membrane, disulfide bond, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, transmembrane
Biological source	Homo sapiens (human)
Cellular location	Prostasin: Cell membrane; Single-pass membrane protein. Prostasin light chain: Secreted, extracellular space. Prostasin heavy chain: Secreted, extracellular space: Q16651
Total number of polymer chains	1
Total formula weight	28450.82
Authors	Spraggon, G.,Hornsby, M.,Shipway, A.,Harris, J.L.,Lesley, S.A. (deposition date: 2009-04-03, release date: 2009-04-21, Last modification date: 2023-09-06)
Primary citation	Spraggon, G.,Hornsby, M.,Shipway, A.,Tully, D.C.,Bursulaya, B.,Danahay, H.,Harris, J.L.,Lesley, S.A. Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations. Protein Sci., 18:1081-1094, 2009 Cited by PubMed: 19388054 DOI: 10.1002/pro.118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation