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1LTS
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BU of 1lts by Molmil
REFINED STRUCTURE OF E. COLI HEAT LABILE ENTEROTOXIN, A CLOSE RELATIVE OF CHOLERA TOXIN
Descriptor: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B
Authors:Sixma, T.K, Hol, W.G.J.
Deposit date:1992-07-15
Release date:1994-01-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin.
J.Mol.Biol., 230, 1993
1LTT
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BU of 1ltt by Molmil
LACTOSE BINDING TO HEAT-LABILE ENTEROTOXIN REVEALED BY X-RAY CRYSTALLOGRAPHY
Descriptor: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B, ...
Authors:Sixma, T.K, Hol, W.G.J.
Deposit date:1992-07-15
Release date:1994-01-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography.
Nature, 355, 1992
4UF6
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BU of 4uf6 by Molmil
UCH-L5 in complex with ubiquitin-propargyl bound to an activating fragment of INO80G
Descriptor: NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN, POLYUBIQUITIN-B, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5
Authors:Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K.
Deposit date:2014-12-23
Release date:2015-03-04
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (3.69 Å)
Cite:Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G.
Mol.Cell, 57, 2015
6I5F
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BU of 6i5f by Molmil
Crystal structure of DNA-free E.coli MutS P839E dimer mutant
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA mismatch repair protein MutS, GLYCEROL, ...
Authors:Bhairosing-Kok, D, Groothuizen, F.S, Fish, A, Dharadhar, S, Winterwerp, H.H.K, Sixma, T.K.
Deposit date:2018-11-13
Release date:2019-08-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Sharp kinking of a coiled-coil in MutS allows DNA binding and release.
Nucleic Acids Res., 47, 2019
8AG6
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BU of 8ag6 by Molmil
human MutSalpha (MSH2/MSH6) binding to DNA with a GT mismatch
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (50-MER), DNA mismatch repair protein Msh2, ...
Authors:Bruekner, S.R, Sixma, T.K.
Deposit date:2022-07-19
Release date:2023-01-25
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Unexpected moves: a conformational change in MutS alpha enables high-affinity DNA mismatch binding.
Nucleic Acids Res., 51, 2023
2XNV
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BU of 2xnv by Molmil
Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors
Descriptor: 2-(2-(4-PHENYLPIPERIDIN-1-YL)ETHYL)-1H-INDOLE, SOLUBLE ACETYLCHOLINE RECEPTOR
Authors:Rucktooa, P, Akdemir, A, deEsch, I, Sixma, T.K.
Deposit date:2010-08-06
Release date:2011-08-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors.
Bioorg.Med.Chem., 19, 2011
2XNT
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BU of 2xnt by Molmil
Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors
Descriptor: (2S)-2-[(4-CHLOROBENZYL)OXY]-2-PHENYLETHANAMINE, BROMIDE ION, SOLUBLE ACETYLCHOLINE RECEPTOR
Authors:Rucktooa, P, Akdemir, A, deEsch, I, Sixma, T.K.
Deposit date:2010-08-06
Release date:2011-08-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors.
Bioorg.Med.Chem., 19, 2011
7R2G
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BU of 7r2g by Molmil
USP15 D1D2 in catalytically-competent state bound to mitoxantrone stack (isoform 2)
Descriptor: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, GLYCEROL, Ubiquitin carboxyl-terminal hydrolase 15, ...
Authors:Priyanka, A, Sixma, T.K.
Deposit date:2022-02-04
Release date:2022-06-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain.
J.Struct.Biol., 214, 2022
5FWI
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BU of 5fwi by Molmil
structure of usp7 catalytic domain and three ubl-domains
Descriptor: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7
Authors:Kim, R.Q, van Dijk, W.J, Sixma, T.K.
Deposit date:2016-02-17
Release date:2016-06-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of Usp7 Catalytic Domain and Three Ubl-Domains Reveals a Connector Alpha-Helix with Regulatory Role.
J.Struct.Biol., 195, 2016
8QH5
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BU of 8qh5 by Molmil
CryoEM structure of UVSSA(VHS)-CSA-DDB1-DDA1
Descriptor: DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, DNA excision repair protein ERCC-8, ...
Authors:Lee, S.-H, Sixma, T.K.
Deposit date:2023-09-06
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:CryoEM structure of UVSSA(VHS)-CSA-DDB1-DDA1
To Be Published
6QLY
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BU of 6qly by Molmil
IDOL FERM domain
Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase MYLIP, SULFATE ION
Authors:Martinelli, L, Sixma, T.K.
Deposit date:2019-02-01
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site.
J.Biol.Chem., 295, 2020
6QML
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BU of 6qml by Molmil
UCHL3 in complex with synthetic, K27-linked diubiquitin
Descriptor: 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ...
Authors:Murachelli, A.G, Sixma, T.K.
Deposit date:2019-02-07
Release date:2020-02-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap.
Cell Chem Biol, 28, 2021
6YN1
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BU of 6yn1 by Molmil
Crystal structure of histone chaperone APLF acidic domain bound to the histone H2A-H2B-H3-H4 octamer
Descriptor: Aprataxin and PNK-like factor, CHLORIDE ION, GLYCEROL, ...
Authors:Corbeski, I, Guo, X, Van Ingen, H, Sixma, T.K.
Deposit date:2020-04-10
Release date:2021-11-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF.
Sci Adv, 8, 2022
4UEL
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BU of 4uel by Molmil
UCH-L5 in complex with ubiquitin-propargyl bound to the RPN13 DEUBAD domain
Descriptor: POLYUBIQUITIN-B, PROTEASOMAL UBIQUITIN RECEPTOR ADRM1, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5
Authors:Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K.
Deposit date:2014-12-18
Release date:2015-03-04
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G.
Mol.Cell, 57, 2015
4UEM
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BU of 4uem by Molmil
UCH-L5 in complex with the RPN13 DEUBAD domain
Descriptor: PROTEASOMAL UBIQUITIN RECEPTOR ADRM1, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5
Authors:Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K.
Deposit date:2014-12-18
Release date:2015-03-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G.
Mol.Cell, 57, 2015
4UF5
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BU of 4uf5 by Molmil
Crystal structure of UCH-L5 in complex with inhibitory fragment of INO80G
Descriptor: NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5
Authors:Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K.
Deposit date:2014-12-23
Release date:2015-03-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G.
Mol.Cell, 57, 2015
1UV6
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BU of 1uv6 by Molmil
X-ray structure of acetylcholine binding protein (AChBP) in complex with carbamylcholine
Descriptor: 2-[(AMINOCARBONYL)OXY]-N,N,N-TRIMETHYLETHANAMINIUM, ACETYLCHOLINE-BINDING PROTEIN
Authors:Celie, P.H.N, Van Rossum-fikkert, S.E, Van Dijk, W.J, Brejc, K, Smit, A.B, Sixma, T.K.
Deposit date:2004-01-15
Release date:2004-03-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in Achbp Crystal Structures
Neuron, 41, 2004
1UW6
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BU of 1uw6 by Molmil
X-ray structure of acetylcholine binding protein (AChBP) in complex with nicotine
Descriptor: (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, ACETYLCHOLINE-BINDING PROTEIN
Authors:Celie, P.H.N, Van Rossum-fikkert, S.E, Van Dijk, W.J, Brejc, K, Smit, A.B, Sixma, T.K.
Deposit date:2004-01-30
Release date:2004-03-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in Achbp Crystal Structures
Neuron, 41, 2004
1UX2
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BU of 1ux2 by Molmil
X-ray structure of acetylcholine binding protein (AChBP)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETYLCHOLINE BINDING PROTEIN, ...
Authors:Celie, P.H.N, Van Rossum-fikkert, S.E, Van Dijk, W.J, Brejc, K, Smit, A.B, Sixma, T.K.
Deposit date:2004-02-18
Release date:2004-03-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in Achbp Crystal Structures
Neuron, 41, 2004
1LTA
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BU of 1lta by Molmil
2.2 ANGSTROMS CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN (LT) WITH BOUND GALACTOSE
Descriptor: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B, ...
Authors:Merritt, E.A, Sixma, T.K, Kalk, K.H, Van Zanten, B.A.M, Hol, W.G.J.
Deposit date:1993-09-15
Release date:1994-01-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT).
Mol.Microbiol., 13, 1994
7AI7
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BU of 7ai7 by Molmil
MutS in Intermediate state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(P*CP*TP*TP*AP*GP*CP*TP*TP*AP*GP*GP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*CP*CP*TP*AP*AP*CP*TP*AP*AP*G)-3'), ...
Authors:Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H.
Deposit date:2020-09-26
Release date:2021-03-31
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021
7AIB
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BU of 7aib by Molmil
MutS-MutL in clamp state
Descriptor: DNA (30-MER), DNA mismatch repair protein MutL, DNA mismatch repair protein MutS, ...
Authors:Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H.
Deposit date:2020-09-26
Release date:2021-03-31
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021
7AI5
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BU of 7ai5 by Molmil
MutS in Scanning state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*CP*GP*GP*TP*AP*CP*CP*CP*AP*AP*TP*TP*CP*GP*CP*CP*CP*TP*AP*TP*AP*G)-3'), DNA (5'-D(P*CP*TP*AP*TP*AP*GP*GP*GP*CP*GP*AP*AP*TP*TP*GP*GP*GP*TP*AP*CP*CP*G)-3'), ...
Authors:Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H.
Deposit date:2020-09-26
Release date:2021-03-31
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021
7AI6
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BU of 7ai6 by Molmil
MutS in mismatch bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (25-MER), DNA mismatch repair protein MutS
Authors:Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H.
Deposit date:2020-09-26
Release date:2021-03-31
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021
7AIC
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BU of 7aic by Molmil
MutS-MutL in clamp state (kinked clamp domain)
Descriptor: DNA (30-MER), DNA mismatch repair protein MutL, DNA mismatch repair protein MutS, ...
Authors:Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H.
Deposit date:2020-09-26
Release date:2021-03-31
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (5 Å)
Cite:The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021

 

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