8AG6

human MutSalpha (MSH2/MSH6) binding to DNA with a GT mismatch

Summary for 8AG6

Entry DOI	10.2210/pdb8ag6/pdb
EMDB information	15417 15518 15519
Descriptor	DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh6, DNA (50-MER), ... (6 entities in total)
Functional Keywords	dna mismatch repair, mmr, mutsa, lynch syndrome, dna binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	294902.44
Authors	Bruekner, S.R.,Sixma, T.K. (deposition date: 2022-07-19, release date: 2023-01-25, Last modification date: 2023-03-01)
Primary citation	Bruekner, S.R.,Pieters, W.,Fish, A.,Liaci, A.M.,Scheffers, S.,Rayner, E.,Kaldenbach, D.,Drost, L.,Dekker, M.,van Hees-Stuivenberg, S.,Delzenne-Goette, E.,de Konink, C.,Houlleberghs, H.,Dubbink, H.J.,AlSaegh, A.,de Wind, N.,Forster, F.,Te Riele, H.,Sixma, T.K. Unexpected moves: a conformational change in MutS alpha enables high-affinity DNA mismatch binding. Nucleic Acids Res., 51:1173-1188, 2023 Cited by PubMed: 36715327 DOI: 10.1093/nar/gkad015 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.8 Å)

Structure validation